A triplex for intestinal protection: Neurons, microbes, and goblet cells

A triplex for intestinal protection: Neurons, microbes, and goblet cells

Diverse intestinal components (e.g., gut-associated neurons, immune cells, gut microbes, and epithelium) are intimately intertwined with each other to maintain homeostasis in the gut. In a recent issue of Cell, Zhang et al. (2022) and Yang et al. (2022) present complementary studies uncovering inter...

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Veröffentlicht in:Immunity (Cambridge, Mass.) Mass.), 2022-12, Vol.55 (12), p.2228-2230
Hauptverfasser: Kim, Dong-Yoon, Mucida, Daniel
Format: Artikel
Sprache:eng
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Gastrointestinal Microbiome
Goblet Cells
Homeostasis
Intestinal Mucosa
Neurons
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Mucida, Daniel
description Diverse intestinal components (e.g., gut-associated neurons, immune cells, gut microbes, and epithelium) are intimately intertwined with each other to maintain homeostasis in the gut. In a recent issue of Cell, Zhang et al. (2022) and Yang et al. (2022) present complementary studies uncovering interactions between nociceptor neurons, gut epithelium, and the microbiome to protect intestinal tissue from inflammation. Diverse intestinal components (e.g., gut-associated neurons, immune cells, gut microbes, and epithelium) are intimately intertwined with each other to maintain homeostasis in the gut. In a recent issue of Cell, Zhang et al. and Yang et al. present complementary studies uncovering interactions between nociceptor neurons, gut epithelium, and the microbiome to protect intestinal tissue from inflammation.
doi_str_mv 10.1016/j.immuni.2022.11.006
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subjects Gastrointestinal Microbiome
Goblet Cells
Homeostasis
Intestinal Mucosa
Neurons
title A triplex for intestinal protection: Neurons, microbes, and goblet cells
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