MUC1 promotes glioblastoma progression and TMZ resistance by stabilizing EGFRvIII

Epidermal growth factor receptor variant III (EGFRvIII) is a mutant isoform of EGFR with a deletion of exons 2–7 making it insensitive to EGF stimulation and downstream signal constitutive activation. However, the mechanism underlying the stability of EGFRvIII remains unclear. Based on CRISPR-Cas9 l...

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Veröffentlicht in:	Pharmacological research 2023-01, Vol.187, p.106606-106606, Article 106606
Hauptverfasser:	Tong, Fei, Zhao, Ji-xing, Fang, Zi-yuan, Cui, Xiao-teng, Su, Dong-yuan, Liu, Xing, Zhou, Jun-hu, Wang, Guang-xiu, Qiu, Zhi-jun, Liu, Shi-zhong, Fu, Jun-qi, Kang, Chun-sheng, Wang, Jia-chong, Wang, Qi-xue
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain Neoplasms - drug therapy Brain Neoplasms - genetics Brain Neoplasms - metabolism Cell Line, Tumor EPIC-1027 Epidermal growth factor receptor variant III Glioblastoma Glioblastoma - drug therapy Glioblastoma - genetics Glioblastoma - metabolism Glioma Humans Mucin 1-C Mucin-1 - genetics NF-kappa B - metabolism NF-κB Temozolomide - pharmacology
Online-Zugang:	Volltext
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