Copper-Catalyzed Thiolation of Hydrazones with Sodium Sulfinates: A Straightforward Synthesis of Benzylic Thioethers
A facile and sustainable protocol for the thiolation of hydrazones with sodium sulfinates has been developed in the presence of CuBr2 and DBU in DMF to afford diverse benzylic thioethers. Control experiments reveal a radical pathway involving a thiyl radical as a key intermediate.
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| Veröffentlicht in: | Journal of organic chemistry 2023-01, Vol.88 (1), p.475-482 |
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| container_end_page | 482 |
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| container_issue | 1 |
| container_start_page | 475 |
| container_title | Journal of organic chemistry |
| container_volume | 88 |
| creator | Pandey, Anand Kumar Chand, Shiv Sharma, Anup Kumar Singh, Krishna Nand |
| description | A facile and sustainable protocol for the thiolation of hydrazones with sodium sulfinates has been developed in the presence of CuBr2 and DBU in DMF to afford diverse benzylic thioethers. Control experiments reveal a radical pathway involving a thiyl radical as a key intermediate. |
| doi_str_mv | 10.1021/acs.joc.2c02451 |
| format | Article |
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| ispartof | Journal of organic chemistry, 2023-01, Vol.88 (1), p.475-482 |
| issn | 0022-3263 1520-6904 |
| language | eng |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | Catalysis Copper Hydrazones Sodium Sulfides |
| title | Copper-Catalyzed Thiolation of Hydrazones with Sodium Sulfinates: A Straightforward Synthesis of Benzylic Thioethers |
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