Autonomous rhythmic activity in glioma networks drives brain tumour growth

Diffuse gliomas, particularly glioblastomas, are incurable brain tumours 1 . They are characterized by networks of interconnected brain tumour cells that communicate via Ca 2+ transients 2 – 6 . However, the networks’ architecture and communication strategy and how these influence tumour biology rem...

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Veröffentlicht in:	Nature (London) 2023-01, Vol.613 (7942), p.179-186
Hauptverfasser:	Hausmann, David, Hoffmann, Dirk C., Venkataramani, Varun, Jung, Erik, Horschitz, Sandra, Tetzlaff, Svenja K., Jabali, Ammar, Hai, Ling, Kessler, Tobias, Azoŕin, Daniel D., Weil, Sophie, Kourtesakis, Alexandros, Sievers, Philipp, Habel, Antje, Breckwoldt, Michael O., Karreman, Matthia A., Ratliff, Miriam, Messmer, Julia M., Yang, Yvonne, Reyhan, Ekin, Wendler, Susann, Löb, Cathrin, Mayer, Chanté, Figarella, Katherine, Osswald, Matthias, Solecki, Gergely, Sahm, Felix, Garaschuk, Olga, Kuner, Thomas, Koch, Philipp, Schlesner, Matthias, Wick, Wolfgang, Winkler, Frank
Format:	Artikel
Sprache:	eng
Schlagworte:	13/100 14/1 14/10 14/19 14/63 14/69 38/89 42 42/35 42/41 59/57 631/67/1922 64/60 692/617/375/1922 82/80 Ablation Animals Brain Brain - metabolism Brain - pathology Brain cancer Brain Neoplasms - genetics Brain Neoplasms - metabolism Brain Neoplasms - pathology Brain tumors Calcium - metabolism Calcium ions Calcium Signaling Calcium signalling Cell Death Cell interactions Cell viability Communication Drug development Frequency dependence Glioblastoma Glioblastoma - genetics Glioblastoma - metabolism Glioblastoma - pathology Glioblastoma cells Glioma Hubs Humanities and Social Sciences Lasers MAP kinase MAP Kinase Signaling System Mice multidisciplinary Network analysis Network design Network hubs Network topologies NF-kappa B - metabolism NF-κB protein Oscillations Potassium Potassium channels (calcium-gated) Rhythms Science Science (multidisciplinary) Survival Analysis Topology Tumors
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