Resistance and phylogeny guided discovery reveals structural novelty of tetracycline antibiotics

Tetracyclines are a class of antibiotics that exhibited potent activity against a wide range of Gram-positive and Gram-negative bacteria, yet only five members were isolated from actinobacteria, with two of them approved as clinical drugs. In this work, we developed a genome mining strategy using a...

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Veröffentlicht in:	Chemical science (Cambridge) 2022-11, Vol.13 (43), p.12892-12898
Hauptverfasser:	Li, Ling Yu, Hu, Yi Ling, Sun, Jia Lin, Yu, Long Bo, Shi, Jing, Wang, Zi Ru, Guo, Zhi Kai, Zhang, Bo, Guo, Wen Jie, Tan, Ren Xiang, Ge, Hui Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics Biosynthesis Chemistry Tetracyclines
Online-Zugang:	Volltext
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