Adrenal incidentaloma: Do patients with apparently nonfunctioning mass or autonomous cortisol secretion have similar or different clinical and metabolic features?
Objective Although there is growing evidence associating nonfunctioning adrenal incidentalomas (NFAI) with cardiovascular risk factors, there are limited data whether NFAI and autonomous cortisol secretion (ACS) groups have similar or different clinical and metabolic features. The aim of this study...
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| Veröffentlicht in: | Clinical endocrinology (Oxford) 2023-05, Vol.98 (5), p.662-669 |
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| creator | Rebelo, João Felipe Dickson Costa, Julia Magarão Junqueira, Fernanda Damasceno Fonseca, Adelmo de Oliveira Almeida, Ana Beatriz Alcantara Bérenger Samarcos Moraes, Aline Barbosa Vieira Neto, Leonardo |
| description | Objective
Although there is growing evidence associating nonfunctioning adrenal incidentalomas (NFAI) with cardiovascular risk factors, there are limited data whether NFAI and autonomous cortisol secretion (ACS) groups have similar or different clinical and metabolic features. The aim of this study is to compare cardiometabolic clinic parameters among patients with ACS and NFAI, as well as controls.
Design
Cross‐sectional study.
Patients
Eighty nine NFAI, 58 ACS and 64 controls were evaluated.
Measurements
Diagnosis of NFAI (1 mg dexamethasone suppression test [1 mg‐DST] ≤50 nmol/L [≤1.8 μg/dl]) and ACS (1 mg‐DST > 50 nmol/L [> 1.8 μg/dl]) was established according to current guidelines. The control group was selected based on a normal adrenal imaging exam.
Results
There were no differences between groups regarding age, gender, ethnicity, menopause or body mass index. Patients with adrenal incidentaloma presented higher frequency of hypertension (74.1 vs. 57.8%; p = .02), resistant hypertension (45.4 vs. 9.4%; p |
| doi_str_mv | 10.1111/cen.14861 |
| format | Article |
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Although there is growing evidence associating nonfunctioning adrenal incidentalomas (NFAI) with cardiovascular risk factors, there are limited data whether NFAI and autonomous cortisol secretion (ACS) groups have similar or different clinical and metabolic features. The aim of this study is to compare cardiometabolic clinic parameters among patients with ACS and NFAI, as well as controls.
Design
Cross‐sectional study.
Patients
Eighty nine NFAI, 58 ACS and 64 controls were evaluated.
Measurements
Diagnosis of NFAI (1 mg dexamethasone suppression test [1 mg‐DST] ≤50 nmol/L [≤1.8 μg/dl]) and ACS (1 mg‐DST > 50 nmol/L [> 1.8 μg/dl]) was established according to current guidelines. The control group was selected based on a normal adrenal imaging exam.
Results
There were no differences between groups regarding age, gender, ethnicity, menopause or body mass index. Patients with adrenal incidentaloma presented higher frequency of hypertension (74.1 vs. 57.8%; p = .02), resistant hypertension (45.4 vs. 9.4%; p < .001), dyslipidemia (80.1 vs. 63.9%; p = .01), as well as metabolic syndrome (84.2 vs. 61.7%; p = .001) compared to the controls, respectively. NFAI and ACS patients presented similar frequency of arterial hypertension (70.8 vs. 79.3%) and resistant hypertension (41.3 vs. 51.1%), dyslipidemia (79.3 vs. 81.5%) and metabolic syndrome (83.3 vs. 85.7%); also, levels of HbA1c were similar between the groups. Binary logistic regression showed that NFAI (p = .004) and ACS (p = .001) were independent predictors for resistant hypertension (p = .003); also, ACS was an independent predictor for metabolic syndrome (p = .04).
Conclusions
NFAI and ACS presented a higher frequency of cardiometabolic morbidities in comparison with individuals with normal adrenal glands. Additionally, we demonstrated that both ACS and NFAI groups have similar cardiometabolic conditions.</description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1111/cen.14861</identifier><identifier>PMID: 36514987</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>adrenal adenoma ; Adrenal Gland Neoplasms - complications ; Adrenal glands ; adrenal incidentaloma ; Body mass index ; Cardiovascular diseases ; Cortisol ; Cross-Sectional Studies ; Dexamethasone ; Dyslipidemia ; Female ; Humans ; Hydrocortisone - metabolism ; Hypertension ; Hypertension - complications ; Menopause ; Metabolic disorders ; Metabolic syndrome ; Metabolic Syndrome - etiology ; Risk factors ; Secretion</subject><ispartof>Clinical endocrinology (Oxford), 2023-05, Vol.98 (5), p.662-669</ispartof><rights>2022 John Wiley & Sons Ltd.</rights><rights>2023 John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3531-20e2b9069c024351b9f9e2ccad874d8b4f28a81c0d2bacd2b17245d17ad24df63</citedby><cites>FETCH-LOGICAL-c3531-20e2b9069c024351b9f9e2ccad874d8b4f28a81c0d2bacd2b17245d17ad24df63</cites><orcidid>0000-0001-7533-7458 ; 0000-0002-1595-3985</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fcen.14861$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fcen.14861$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36514987$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rebelo, João Felipe Dickson</creatorcontrib><creatorcontrib>Costa, Julia Magarão</creatorcontrib><creatorcontrib>Junqueira, Fernanda Damasceno</creatorcontrib><creatorcontrib>Fonseca, Adelmo de Oliveira</creatorcontrib><creatorcontrib>Almeida, Ana Beatriz Alcantara Bérenger Samarcos</creatorcontrib><creatorcontrib>Moraes, Aline Barbosa</creatorcontrib><creatorcontrib>Vieira Neto, Leonardo</creatorcontrib><title>Adrenal incidentaloma: Do patients with apparently nonfunctioning mass or autonomous cortisol secretion have similar or different clinical and metabolic features?</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clin Endocrinol (Oxf)</addtitle><description>Objective
Although there is growing evidence associating nonfunctioning adrenal incidentalomas (NFAI) with cardiovascular risk factors, there are limited data whether NFAI and autonomous cortisol secretion (ACS) groups have similar or different clinical and metabolic features. The aim of this study is to compare cardiometabolic clinic parameters among patients with ACS and NFAI, as well as controls.
Design
Cross‐sectional study.
Patients
Eighty nine NFAI, 58 ACS and 64 controls were evaluated.
Measurements
Diagnosis of NFAI (1 mg dexamethasone suppression test [1 mg‐DST] ≤50 nmol/L [≤1.8 μg/dl]) and ACS (1 mg‐DST > 50 nmol/L [> 1.8 μg/dl]) was established according to current guidelines. The control group was selected based on a normal adrenal imaging exam.
Results
There were no differences between groups regarding age, gender, ethnicity, menopause or body mass index. Patients with adrenal incidentaloma presented higher frequency of hypertension (74.1 vs. 57.8%; p = .02), resistant hypertension (45.4 vs. 9.4%; p < .001), dyslipidemia (80.1 vs. 63.9%; p = .01), as well as metabolic syndrome (84.2 vs. 61.7%; p = .001) compared to the controls, respectively. NFAI and ACS patients presented similar frequency of arterial hypertension (70.8 vs. 79.3%) and resistant hypertension (41.3 vs. 51.1%), dyslipidemia (79.3 vs. 81.5%) and metabolic syndrome (83.3 vs. 85.7%); also, levels of HbA1c were similar between the groups. Binary logistic regression showed that NFAI (p = .004) and ACS (p = .001) were independent predictors for resistant hypertension (p = .003); also, ACS was an independent predictor for metabolic syndrome (p = .04).
Conclusions
NFAI and ACS presented a higher frequency of cardiometabolic morbidities in comparison with individuals with normal adrenal glands. Additionally, we demonstrated that both ACS and NFAI groups have similar cardiometabolic conditions.</description><subject>adrenal adenoma</subject><subject>Adrenal Gland Neoplasms - complications</subject><subject>Adrenal glands</subject><subject>adrenal incidentaloma</subject><subject>Body mass index</subject><subject>Cardiovascular diseases</subject><subject>Cortisol</subject><subject>Cross-Sectional Studies</subject><subject>Dexamethasone</subject><subject>Dyslipidemia</subject><subject>Female</subject><subject>Humans</subject><subject>Hydrocortisone - metabolism</subject><subject>Hypertension</subject><subject>Hypertension - complications</subject><subject>Menopause</subject><subject>Metabolic disorders</subject><subject>Metabolic syndrome</subject><subject>Metabolic Syndrome - etiology</subject><subject>Risk factors</subject><subject>Secretion</subject><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10U1vFSEUBmBiNPZaXfgHDIkbXUwLDPPlpmmu9SNpdKPryRk4WBoGRmBs7t_xl8p4qwsTWUBCnrzh8BLynLMzXta5Qn_GZd_yB2TH67aphGibh2THasYq1rbyhDxJ6ZYx1vSse0xOiuFy6Lsd-XmpI3pw1HplNfoMLszwhr4NdIFsy0WidzbfUFgWKDK7A_XBm9WrbIO3_hudISUaIoU1Bx_msCaqQsw2BUcTqogbpDfwA2mys3UQN62tMbgFUuWst6o8AbymM2aYgrOKGoS8RkwXT8kjAy7hs_vzlHx9d_Vl_6G6_vz-4_7yulJ1U_NKMBTTwNpBMSHrhk-DGVAoBbrvpO4naUQPPVdMiwlU2XgnZKN5B1pIbdr6lLw65i4xfF8x5XG2SaFz4LEMNYqukQ2TXdsU-vIfehvWWL5xU0Pd1wWyol4flYohpYhmXKKdIR5GzsatuLEUN_4urtgX94nrNKP-K_80VcD5EdxZh4f_J437q0_HyF_pIaXc</recordid><startdate>202305</startdate><enddate>202305</enddate><creator>Rebelo, João Felipe Dickson</creator><creator>Costa, Julia Magarão</creator><creator>Junqueira, Fernanda Damasceno</creator><creator>Fonseca, Adelmo de Oliveira</creator><creator>Almeida, Ana Beatriz Alcantara Bérenger Samarcos</creator><creator>Moraes, Aline Barbosa</creator><creator>Vieira Neto, Leonardo</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7533-7458</orcidid><orcidid>https://orcid.org/0000-0002-1595-3985</orcidid></search><sort><creationdate>202305</creationdate><title>Adrenal incidentaloma: Do patients with apparently nonfunctioning mass or autonomous cortisol secretion have similar or different clinical and metabolic features?</title><author>Rebelo, João Felipe Dickson ; Costa, Julia Magarão ; Junqueira, Fernanda Damasceno ; Fonseca, Adelmo de Oliveira ; Almeida, Ana Beatriz Alcantara Bérenger Samarcos ; Moraes, Aline Barbosa ; Vieira Neto, Leonardo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3531-20e2b9069c024351b9f9e2ccad874d8b4f28a81c0d2bacd2b17245d17ad24df63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>adrenal adenoma</topic><topic>Adrenal Gland Neoplasms - complications</topic><topic>Adrenal glands</topic><topic>adrenal incidentaloma</topic><topic>Body mass index</topic><topic>Cardiovascular diseases</topic><topic>Cortisol</topic><topic>Cross-Sectional Studies</topic><topic>Dexamethasone</topic><topic>Dyslipidemia</topic><topic>Female</topic><topic>Humans</topic><topic>Hydrocortisone - metabolism</topic><topic>Hypertension</topic><topic>Hypertension - complications</topic><topic>Menopause</topic><topic>Metabolic disorders</topic><topic>Metabolic syndrome</topic><topic>Metabolic Syndrome - etiology</topic><topic>Risk factors</topic><topic>Secretion</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rebelo, João Felipe Dickson</creatorcontrib><creatorcontrib>Costa, Julia Magarão</creatorcontrib><creatorcontrib>Junqueira, Fernanda Damasceno</creatorcontrib><creatorcontrib>Fonseca, Adelmo de Oliveira</creatorcontrib><creatorcontrib>Almeida, Ana Beatriz Alcantara Bérenger Samarcos</creatorcontrib><creatorcontrib>Moraes, Aline Barbosa</creatorcontrib><creatorcontrib>Vieira Neto, Leonardo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rebelo, João Felipe Dickson</au><au>Costa, Julia Magarão</au><au>Junqueira, Fernanda Damasceno</au><au>Fonseca, Adelmo de Oliveira</au><au>Almeida, Ana Beatriz Alcantara Bérenger Samarcos</au><au>Moraes, Aline Barbosa</au><au>Vieira Neto, Leonardo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adrenal incidentaloma: Do patients with apparently nonfunctioning mass or autonomous cortisol secretion have similar or different clinical and metabolic features?</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clin Endocrinol (Oxf)</addtitle><date>2023-05</date><risdate>2023</risdate><volume>98</volume><issue>5</issue><spage>662</spage><epage>669</epage><pages>662-669</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><abstract>Objective
Although there is growing evidence associating nonfunctioning adrenal incidentalomas (NFAI) with cardiovascular risk factors, there are limited data whether NFAI and autonomous cortisol secretion (ACS) groups have similar or different clinical and metabolic features. The aim of this study is to compare cardiometabolic clinic parameters among patients with ACS and NFAI, as well as controls.
Design
Cross‐sectional study.
Patients
Eighty nine NFAI, 58 ACS and 64 controls were evaluated.
Measurements
Diagnosis of NFAI (1 mg dexamethasone suppression test [1 mg‐DST] ≤50 nmol/L [≤1.8 μg/dl]) and ACS (1 mg‐DST > 50 nmol/L [> 1.8 μg/dl]) was established according to current guidelines. The control group was selected based on a normal adrenal imaging exam.
Results
There were no differences between groups regarding age, gender, ethnicity, menopause or body mass index. Patients with adrenal incidentaloma presented higher frequency of hypertension (74.1 vs. 57.8%; p = .02), resistant hypertension (45.4 vs. 9.4%; p < .001), dyslipidemia (80.1 vs. 63.9%; p = .01), as well as metabolic syndrome (84.2 vs. 61.7%; p = .001) compared to the controls, respectively. NFAI and ACS patients presented similar frequency of arterial hypertension (70.8 vs. 79.3%) and resistant hypertension (41.3 vs. 51.1%), dyslipidemia (79.3 vs. 81.5%) and metabolic syndrome (83.3 vs. 85.7%); also, levels of HbA1c were similar between the groups. Binary logistic regression showed that NFAI (p = .004) and ACS (p = .001) were independent predictors for resistant hypertension (p = .003); also, ACS was an independent predictor for metabolic syndrome (p = .04).
Conclusions
NFAI and ACS presented a higher frequency of cardiometabolic morbidities in comparison with individuals with normal adrenal glands. Additionally, we demonstrated that both ACS and NFAI groups have similar cardiometabolic conditions.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>36514987</pmid><doi>10.1111/cen.14861</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-7533-7458</orcidid><orcidid>https://orcid.org/0000-0002-1595-3985</orcidid></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | adrenal adenoma Adrenal Gland Neoplasms - complications Adrenal glands adrenal incidentaloma Body mass index Cardiovascular diseases Cortisol Cross-Sectional Studies Dexamethasone Dyslipidemia Female Humans Hydrocortisone - metabolism Hypertension Hypertension - complications Menopause Metabolic disorders Metabolic syndrome Metabolic Syndrome - etiology Risk factors Secretion |
| title | Adrenal incidentaloma: Do patients with apparently nonfunctioning mass or autonomous cortisol secretion have similar or different clinical and metabolic features? |
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