How to detect cancer early using cell-free DNA

Cell-free circulating DNA (cfDNA) analyses may enable multi-cancer early detection (MCED), but the most suitable method is unknown. In this issue of Cancer Cell, Jamshidi et al. compare ten machine-learning classifiers using various cfDNA features and conclude that cfDNA methylation patterns are mos...

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Veröffentlicht in:	Cancer cell 2022-12, Vol.40 (12), p.1464-1466
Hauptverfasser:	Hasenleithner, Samantha O., Speicher, Michael R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers, Tumor - genetics Cell-Free Nucleic Acids - genetics DNA Methylation Early Detection of Cancer Humans Neoplasms - diagnosis Neoplasms - genetics
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container_title	Cancer cell
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creator	Hasenleithner, Samantha O. Speicher, Michael R.
description	Cell-free circulating DNA (cfDNA) analyses may enable multi-cancer early detection (MCED), but the most suitable method is unknown. In this issue of Cancer Cell, Jamshidi et al. compare ten machine-learning classifiers using various cfDNA features and conclude that cfDNA methylation patterns are most promising for MCED testing. Cell-free circulating DNA (cfDNA) analyses may enable multi-cancer early detection (MCED), but the most suitable method is unknown. In this issue of Cancer Cell, Jamshidi et al. compare ten machine-learning classifiers using various cfDNA features and conclude that cfDNA methylation patterns are most promising for MCED testing.
doi_str_mv	10.1016/j.ccell.2022.11.009
format	Article
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subjects	Biomarkers, Tumor - genetics Cell-Free Nucleic Acids - genetics DNA Methylation Early Detection of Cancer Humans Neoplasms - diagnosis Neoplasms - genetics
title	How to detect cancer early using cell-free DNA
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