Plasma Macrophage Migration Inhibitory Factor Concentration at Each Spectrum of Tuberculosis
Macrophage migration inhibitory factor (MIF) is an inflammatory mediator in several diseases, including tuberculosis (TB). However, the role of MIF in each stage of TB remains to be further elucidated. Thus, this study aimed to analyze the differences in plasma MIF protein levels in patients with ac...
Gespeichert in:
| Veröffentlicht in: | Journal of interferon & cytokine research 2023-02, Vol.43 (2), p.98-103 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 103 |
|---|---|
| container_issue | 2 |
| container_start_page | 98 |
| container_title | Journal of interferon & cytokine research |
| container_volume | 43 |
| creator | -Hidayah, Najdah -Djaharuddin, Irawaty -Ahmad, Ahyar -Pambudi, Sabar -Halik, Handayani -Subair, Subair -Tenriola, Andi -Mumang, Andi Agus -Lihawa, Nurjannah -Massi, Muhammad Nasrum |
| description | Macrophage migration inhibitory factor (MIF) is an inflammatory mediator in several diseases, including tuberculosis (TB). However, the role of MIF in each stage of TB remains to be further elucidated. Thus, this study aimed to analyze the differences in plasma MIF protein levels in patients with active pulmonary TB, positive and negative interferon-gamma release assay (IGRA) household contacts (HHCs), and healthy controls (HCs). Plasma MIF concentration was significantly higher in patients with active–new pulmonary tuberculosis (ATB) and HHCs compared with HCs (mean ± standard deviation: 17.32 ± 16.85, 16.29 ± 14.21, and 7.29 ± 5.39 ng/mL, respectively;
P
= 0.002). The plasma MIF concentration was not statistically different when compared between patients with ATB, IGRA-positive HHCs (17.44 ± 16.6 ng/mL), and IGRA-negative HHCs (14.34 ± 8.7 ng/mL) (
P
= 0.897). In conclusion, ATB patients, IGRA-positive HHCs, and IGRA-negative HHCs have a higher MIF concentration than HCs. This shows the involvement of MIF in each stage of TB, starting from TB exposure and infection, but not symptomatic, to the active stage. |
| doi_str_mv | 10.1089/jir.2022.0197 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2754501544</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2777094590</sourcerecordid><originalsourceid>FETCH-LOGICAL-c321t-de50c349809600b6bcfcf4fe708b545e3e25e00ae5cac72c6ae0fd43199a91a53</originalsourceid><addsrcrecordid>eNqFkE1P4zAQhi3Eio_CkSuyxIVLumMnjusjqsouEtWutOwNKZq4E-oqiYudHPj3uGrhwIXTO5p59Gr0MHYlYCpgZn5uXJhKkHIKwugjdiaU0pkuSnWcZtAmMwb0KTuPcQMA5UyaE3aal0qUQooz9vy3xdghX6INfrvGF-JL9xJwcL7nD_3a1W7w4Y3fo03J57631A-HOw58gXbN_23JDmHsuG_401hTsGPro4sX7EeDbaTLQ07Y__vF0_x39vjn18P87jGzuRRDtiIFNi_MDEwJUJe1bWxTNKRhVqtCUU5SEQCSsmi1tCUSNKsiF8agEajyCbvd926Dfx0pDlXnoqW2xZ78GCupUw0IVRQJvfmCbvwY-vRdorQGUygDicr2VJISY6Cm2gbXYXirBFQ77VXSXu20Vzvtib8-tI51R6tP-sNzAvI9sFtj37eOkqbhm9p3IQSPVA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2777094590</pqid></control><display><type>article</type><title>Plasma Macrophage Migration Inhibitory Factor Concentration at Each Spectrum of Tuberculosis</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>-Hidayah, Najdah ; -Djaharuddin, Irawaty ; -Ahmad, Ahyar ; -Pambudi, Sabar ; -Halik, Handayani ; -Subair, Subair ; -Tenriola, Andi ; -Mumang, Andi Agus ; -Lihawa, Nurjannah ; -Massi, Muhammad Nasrum</creator><creatorcontrib>-Hidayah, Najdah ; -Djaharuddin, Irawaty ; -Ahmad, Ahyar ; -Pambudi, Sabar ; -Halik, Handayani ; -Subair, Subair ; -Tenriola, Andi ; -Mumang, Andi Agus ; -Lihawa, Nurjannah ; -Massi, Muhammad Nasrum</creatorcontrib><description>Macrophage migration inhibitory factor (MIF) is an inflammatory mediator in several diseases, including tuberculosis (TB). However, the role of MIF in each stage of TB remains to be further elucidated. Thus, this study aimed to analyze the differences in plasma MIF protein levels in patients with active pulmonary TB, positive and negative interferon-gamma release assay (IGRA) household contacts (HHCs), and healthy controls (HCs). Plasma MIF concentration was significantly higher in patients with active–new pulmonary tuberculosis (ATB) and HHCs compared with HCs (mean ± standard deviation: 17.32 ± 16.85, 16.29 ± 14.21, and 7.29 ± 5.39 ng/mL, respectively;
P
= 0.002). The plasma MIF concentration was not statistically different when compared between patients with ATB, IGRA-positive HHCs (17.44 ± 16.6 ng/mL), and IGRA-negative HHCs (14.34 ± 8.7 ng/mL) (
P
= 0.897). In conclusion, ATB patients, IGRA-positive HHCs, and IGRA-negative HHCs have a higher MIF concentration than HCs. This shows the involvement of MIF in each stage of TB, starting from TB exposure and infection, but not symptomatic, to the active stage.</description><identifier>ISSN: 1079-9907</identifier><identifier>EISSN: 1557-7465</identifier><identifier>DOI: 10.1089/jir.2022.0197</identifier><identifier>PMID: 36516121</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc., publishers</publisher><subject>Humans ; Interferon-gamma Release Tests ; Leukocyte migration ; Macrophage migration inhibitory factor ; Macrophage Migration-Inhibitory Factors - blood ; Macrophage Migration-Inhibitory Factors - chemistry ; Plasma ; Short Report ; Tuberculosis ; Tuberculosis - diagnosis ; Tuberculosis - metabolism ; Tuberculosis, Pulmonary - diagnosis ; Tuberculosis, Pulmonary - metabolism ; γ-Interferon</subject><ispartof>Journal of interferon & cytokine research, 2023-02, Vol.43 (2), p.98-103</ispartof><rights>2023, Mary Ann Liebert, Inc., publishers</rights><rights>Copyright Mary Ann Liebert, Inc. Feb 2023</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c321t-de50c349809600b6bcfcf4fe708b545e3e25e00ae5cac72c6ae0fd43199a91a53</cites><orcidid>0000-0002-9811-2080</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36516121$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>-Hidayah, Najdah</creatorcontrib><creatorcontrib>-Djaharuddin, Irawaty</creatorcontrib><creatorcontrib>-Ahmad, Ahyar</creatorcontrib><creatorcontrib>-Pambudi, Sabar</creatorcontrib><creatorcontrib>-Halik, Handayani</creatorcontrib><creatorcontrib>-Subair, Subair</creatorcontrib><creatorcontrib>-Tenriola, Andi</creatorcontrib><creatorcontrib>-Mumang, Andi Agus</creatorcontrib><creatorcontrib>-Lihawa, Nurjannah</creatorcontrib><creatorcontrib>-Massi, Muhammad Nasrum</creatorcontrib><title>Plasma Macrophage Migration Inhibitory Factor Concentration at Each Spectrum of Tuberculosis</title><title>Journal of interferon & cytokine research</title><addtitle>J Interferon Cytokine Res</addtitle><description>Macrophage migration inhibitory factor (MIF) is an inflammatory mediator in several diseases, including tuberculosis (TB). However, the role of MIF in each stage of TB remains to be further elucidated. Thus, this study aimed to analyze the differences in plasma MIF protein levels in patients with active pulmonary TB, positive and negative interferon-gamma release assay (IGRA) household contacts (HHCs), and healthy controls (HCs). Plasma MIF concentration was significantly higher in patients with active–new pulmonary tuberculosis (ATB) and HHCs compared with HCs (mean ± standard deviation: 17.32 ± 16.85, 16.29 ± 14.21, and 7.29 ± 5.39 ng/mL, respectively;
P
= 0.002). The plasma MIF concentration was not statistically different when compared between patients with ATB, IGRA-positive HHCs (17.44 ± 16.6 ng/mL), and IGRA-negative HHCs (14.34 ± 8.7 ng/mL) (
P
= 0.897). In conclusion, ATB patients, IGRA-positive HHCs, and IGRA-negative HHCs have a higher MIF concentration than HCs. This shows the involvement of MIF in each stage of TB, starting from TB exposure and infection, but not symptomatic, to the active stage.</description><subject>Humans</subject><subject>Interferon-gamma Release Tests</subject><subject>Leukocyte migration</subject><subject>Macrophage migration inhibitory factor</subject><subject>Macrophage Migration-Inhibitory Factors - blood</subject><subject>Macrophage Migration-Inhibitory Factors - chemistry</subject><subject>Plasma</subject><subject>Short Report</subject><subject>Tuberculosis</subject><subject>Tuberculosis - diagnosis</subject><subject>Tuberculosis - metabolism</subject><subject>Tuberculosis, Pulmonary - diagnosis</subject><subject>Tuberculosis, Pulmonary - metabolism</subject><subject>γ-Interferon</subject><issn>1079-9907</issn><issn>1557-7465</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1P4zAQhi3Eio_CkSuyxIVLumMnjusjqsouEtWutOwNKZq4E-oqiYudHPj3uGrhwIXTO5p59Gr0MHYlYCpgZn5uXJhKkHIKwugjdiaU0pkuSnWcZtAmMwb0KTuPcQMA5UyaE3aal0qUQooz9vy3xdghX6INfrvGF-JL9xJwcL7nD_3a1W7w4Y3fo03J57631A-HOw58gXbN_23JDmHsuG_401hTsGPro4sX7EeDbaTLQ07Y__vF0_x39vjn18P87jGzuRRDtiIFNi_MDEwJUJe1bWxTNKRhVqtCUU5SEQCSsmi1tCUSNKsiF8agEajyCbvd926Dfx0pDlXnoqW2xZ78GCupUw0IVRQJvfmCbvwY-vRdorQGUygDicr2VJISY6Cm2gbXYXirBFQ77VXSXu20Vzvtib8-tI51R6tP-sNzAvI9sFtj37eOkqbhm9p3IQSPVA</recordid><startdate>20230201</startdate><enddate>20230201</enddate><creator>-Hidayah, Najdah</creator><creator>-Djaharuddin, Irawaty</creator><creator>-Ahmad, Ahyar</creator><creator>-Pambudi, Sabar</creator><creator>-Halik, Handayani</creator><creator>-Subair, Subair</creator><creator>-Tenriola, Andi</creator><creator>-Mumang, Andi Agus</creator><creator>-Lihawa, Nurjannah</creator><creator>-Massi, Muhammad Nasrum</creator><general>Mary Ann Liebert, Inc., publishers</general><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9811-2080</orcidid></search><sort><creationdate>20230201</creationdate><title>Plasma Macrophage Migration Inhibitory Factor Concentration at Each Spectrum of Tuberculosis</title><author>-Hidayah, Najdah ; -Djaharuddin, Irawaty ; -Ahmad, Ahyar ; -Pambudi, Sabar ; -Halik, Handayani ; -Subair, Subair ; -Tenriola, Andi ; -Mumang, Andi Agus ; -Lihawa, Nurjannah ; -Massi, Muhammad Nasrum</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c321t-de50c349809600b6bcfcf4fe708b545e3e25e00ae5cac72c6ae0fd43199a91a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Humans</topic><topic>Interferon-gamma Release Tests</topic><topic>Leukocyte migration</topic><topic>Macrophage migration inhibitory factor</topic><topic>Macrophage Migration-Inhibitory Factors - blood</topic><topic>Macrophage Migration-Inhibitory Factors - chemistry</topic><topic>Plasma</topic><topic>Short Report</topic><topic>Tuberculosis</topic><topic>Tuberculosis - diagnosis</topic><topic>Tuberculosis - metabolism</topic><topic>Tuberculosis, Pulmonary - diagnosis</topic><topic>Tuberculosis, Pulmonary - metabolism</topic><topic>γ-Interferon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>-Hidayah, Najdah</creatorcontrib><creatorcontrib>-Djaharuddin, Irawaty</creatorcontrib><creatorcontrib>-Ahmad, Ahyar</creatorcontrib><creatorcontrib>-Pambudi, Sabar</creatorcontrib><creatorcontrib>-Halik, Handayani</creatorcontrib><creatorcontrib>-Subair, Subair</creatorcontrib><creatorcontrib>-Tenriola, Andi</creatorcontrib><creatorcontrib>-Mumang, Andi Agus</creatorcontrib><creatorcontrib>-Lihawa, Nurjannah</creatorcontrib><creatorcontrib>-Massi, Muhammad Nasrum</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of interferon & cytokine research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>-Hidayah, Najdah</au><au>-Djaharuddin, Irawaty</au><au>-Ahmad, Ahyar</au><au>-Pambudi, Sabar</au><au>-Halik, Handayani</au><au>-Subair, Subair</au><au>-Tenriola, Andi</au><au>-Mumang, Andi Agus</au><au>-Lihawa, Nurjannah</au><au>-Massi, Muhammad Nasrum</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma Macrophage Migration Inhibitory Factor Concentration at Each Spectrum of Tuberculosis</atitle><jtitle>Journal of interferon & cytokine research</jtitle><addtitle>J Interferon Cytokine Res</addtitle><date>2023-02-01</date><risdate>2023</risdate><volume>43</volume><issue>2</issue><spage>98</spage><epage>103</epage><pages>98-103</pages><issn>1079-9907</issn><eissn>1557-7465</eissn><abstract>Macrophage migration inhibitory factor (MIF) is an inflammatory mediator in several diseases, including tuberculosis (TB). However, the role of MIF in each stage of TB remains to be further elucidated. Thus, this study aimed to analyze the differences in plasma MIF protein levels in patients with active pulmonary TB, positive and negative interferon-gamma release assay (IGRA) household contacts (HHCs), and healthy controls (HCs). Plasma MIF concentration was significantly higher in patients with active–new pulmonary tuberculosis (ATB) and HHCs compared with HCs (mean ± standard deviation: 17.32 ± 16.85, 16.29 ± 14.21, and 7.29 ± 5.39 ng/mL, respectively;
P
= 0.002). The plasma MIF concentration was not statistically different when compared between patients with ATB, IGRA-positive HHCs (17.44 ± 16.6 ng/mL), and IGRA-negative HHCs (14.34 ± 8.7 ng/mL) (
P
= 0.897). In conclusion, ATB patients, IGRA-positive HHCs, and IGRA-negative HHCs have a higher MIF concentration than HCs. This shows the involvement of MIF in each stage of TB, starting from TB exposure and infection, but not symptomatic, to the active stage.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc., publishers</pub><pmid>36516121</pmid><doi>10.1089/jir.2022.0197</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-9811-2080</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1079-9907 |
| ispartof | Journal of interferon & cytokine research, 2023-02, Vol.43 (2), p.98-103 |
| issn | 1079-9907 1557-7465 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2754501544 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Humans Interferon-gamma Release Tests Leukocyte migration Macrophage migration inhibitory factor Macrophage Migration-Inhibitory Factors - blood Macrophage Migration-Inhibitory Factors - chemistry Plasma Short Report Tuberculosis Tuberculosis - diagnosis Tuberculosis - metabolism Tuberculosis, Pulmonary - diagnosis Tuberculosis, Pulmonary - metabolism γ-Interferon |
| title | Plasma Macrophage Migration Inhibitory Factor Concentration at Each Spectrum of Tuberculosis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T16%3A25%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Plasma%20Macrophage%20Migration%20Inhibitory%20Factor%20Concentration%20at%20Each%20Spectrum%20of%20Tuberculosis&rft.jtitle=Journal%20of%20interferon%20&%20cytokine%20research&rft.au=-Hidayah,%20Najdah&rft.date=2023-02-01&rft.volume=43&rft.issue=2&rft.spage=98&rft.epage=103&rft.pages=98-103&rft.issn=1079-9907&rft.eissn=1557-7465&rft_id=info:doi/10.1089/jir.2022.0197&rft_dat=%3Cproquest_cross%3E2777094590%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2777094590&rft_id=info:pmid/36516121&rfr_iscdi=true |