Okanin from Coreopsis tinctoria Nutt. alleviates cognitive impairment in bilateral common carotid artery occlusion mice by regulating the miR-7/NLRP3 axis in microglia
Cognitive impairment is the main clinical feature following stroke, and microglia-mediated inflammatory response is a major contributor to it. Nutt., an edible chrysanthemum, is commonly used as a functional ingredient in healthcare beverages and food. Okanin, the main active ingredient of Nutt. flo...
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| Veröffentlicht in: | Food & function 2023-01, Vol.14 (1), p.369-387 |
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| creator | Mi, Yan Xu, Jikai Shi, Ruijia Meng, Qingqi Xu, Libin Liu, Yeshu Guo, Tingting Zhou, Di Liu, Jingyu Li, Wei Li, Ning Hou, Yue |
| description | Cognitive impairment is the main clinical feature following stroke, and microglia-mediated inflammatory response is a major contributor to it.
Nutt., an edible chrysanthemum, is commonly used as a functional ingredient in healthcare beverages and food. Okanin, the main active ingredient of
Nutt. flower, inhibits microglial activation. However, the role of okanin in cognitive impairment following ischemic stroke is still unknown. In this study, we investigated the effect of okanin on ischemic stroke and its underlying mechanism both
and
. Okanin was found to attenuate cognitive impairment in bilateral common carotid artery occlusion (BCCAO) mice, inhibit neuronal loss and microglial activation, decrease NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome activation, and increase miR-7 expression. Okanin suppressed NLRP3 inflammasome activation in oxygen-glucose deprivation (OGD) and lipopolysaccharide (LPS)-stimulated microglia by increasing miR-7 expression and inhibited microglia-induced neuronal injury. This study provides new insights into the role of okanin in ischemic stroke and shows that the miR-7/NLRP3 axis plays an important role in mediating the beneficial effects of okanin on cerebral ischemia. These findings suggest that okanin has great potential as a functional food for stroke recovery. |
| doi_str_mv | 10.1039/d2fo01476a |
| format | Article |
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Nutt., an edible chrysanthemum, is commonly used as a functional ingredient in healthcare beverages and food. Okanin, the main active ingredient of
Nutt. flower, inhibits microglial activation. However, the role of okanin in cognitive impairment following ischemic stroke is still unknown. In this study, we investigated the effect of okanin on ischemic stroke and its underlying mechanism both
and
. Okanin was found to attenuate cognitive impairment in bilateral common carotid artery occlusion (BCCAO) mice, inhibit neuronal loss and microglial activation, decrease NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome activation, and increase miR-7 expression. Okanin suppressed NLRP3 inflammasome activation in oxygen-glucose deprivation (OGD) and lipopolysaccharide (LPS)-stimulated microglia by increasing miR-7 expression and inhibited microglia-induced neuronal injury. This study provides new insights into the role of okanin in ischemic stroke and shows that the miR-7/NLRP3 axis plays an important role in mediating the beneficial effects of okanin on cerebral ischemia. These findings suggest that okanin has great potential as a functional food for stroke recovery.</description><identifier>ISSN: 2042-6496</identifier><identifier>EISSN: 2042-650X</identifier><identifier>DOI: 10.1039/d2fo01476a</identifier><identifier>PMID: 36511396</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Animals ; Beverages ; Carotid arteries ; Carotid artery ; Carotid Artery, Common - metabolism ; Cerebral blood flow ; Cognitive ability ; Cognitive Dysfunction - drug therapy ; Cognitive Dysfunction - metabolism ; Coreopsis ; Coreopsis tinctoria ; Deprivation ; Food ; Functional foods & nutraceuticals ; Glucose ; Impairment ; Inflammasomes ; Inflammasomes - metabolism ; Inflammation ; Inflammatory response ; Ischemia ; Ischemic Stroke ; Lipopolysaccharides ; Mice ; Microglia ; MicroRNAs - genetics ; MicroRNAs - metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein - genetics ; NLR Family, Pyrin Domain-Containing 3 Protein - metabolism ; Occlusion ; Oxygen ; Pyrin protein ; Recovery of function ; Stroke ; Stroke - drug therapy ; Stroke - metabolism</subject><ispartof>Food & function, 2023-01, Vol.14 (1), p.369-387</ispartof><rights>Copyright Royal Society of Chemistry 2023</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c315t-eae4fbeb78b7a8aad4134068b3b6e9f5e0e32db95d01c762b9c8dff76b70d6443</citedby><cites>FETCH-LOGICAL-c315t-eae4fbeb78b7a8aad4134068b3b6e9f5e0e32db95d01c762b9c8dff76b70d6443</cites><orcidid>0000-0003-4143-8597 ; 0000-0002-5028-0691</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36511396$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mi, Yan</creatorcontrib><creatorcontrib>Xu, Jikai</creatorcontrib><creatorcontrib>Shi, Ruijia</creatorcontrib><creatorcontrib>Meng, Qingqi</creatorcontrib><creatorcontrib>Xu, Libin</creatorcontrib><creatorcontrib>Liu, Yeshu</creatorcontrib><creatorcontrib>Guo, Tingting</creatorcontrib><creatorcontrib>Zhou, Di</creatorcontrib><creatorcontrib>Liu, Jingyu</creatorcontrib><creatorcontrib>Li, Wei</creatorcontrib><creatorcontrib>Li, Ning</creatorcontrib><creatorcontrib>Hou, Yue</creatorcontrib><title>Okanin from Coreopsis tinctoria Nutt. alleviates cognitive impairment in bilateral common carotid artery occlusion mice by regulating the miR-7/NLRP3 axis in microglia</title><title>Food & function</title><addtitle>Food Funct</addtitle><description>Cognitive impairment is the main clinical feature following stroke, and microglia-mediated inflammatory response is a major contributor to it.
Nutt., an edible chrysanthemum, is commonly used as a functional ingredient in healthcare beverages and food. Okanin, the main active ingredient of
Nutt. flower, inhibits microglial activation. However, the role of okanin in cognitive impairment following ischemic stroke is still unknown. In this study, we investigated the effect of okanin on ischemic stroke and its underlying mechanism both
and
. Okanin was found to attenuate cognitive impairment in bilateral common carotid artery occlusion (BCCAO) mice, inhibit neuronal loss and microglial activation, decrease NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome activation, and increase miR-7 expression. Okanin suppressed NLRP3 inflammasome activation in oxygen-glucose deprivation (OGD) and lipopolysaccharide (LPS)-stimulated microglia by increasing miR-7 expression and inhibited microglia-induced neuronal injury. This study provides new insights into the role of okanin in ischemic stroke and shows that the miR-7/NLRP3 axis plays an important role in mediating the beneficial effects of okanin on cerebral ischemia. These findings suggest that okanin has great potential as a functional food for stroke recovery.</description><subject>Animals</subject><subject>Beverages</subject><subject>Carotid arteries</subject><subject>Carotid artery</subject><subject>Carotid Artery, Common - metabolism</subject><subject>Cerebral blood flow</subject><subject>Cognitive ability</subject><subject>Cognitive Dysfunction - drug therapy</subject><subject>Cognitive Dysfunction - metabolism</subject><subject>Coreopsis</subject><subject>Coreopsis tinctoria</subject><subject>Deprivation</subject><subject>Food</subject><subject>Functional foods & nutraceuticals</subject><subject>Glucose</subject><subject>Impairment</subject><subject>Inflammasomes</subject><subject>Inflammasomes - metabolism</subject><subject>Inflammation</subject><subject>Inflammatory response</subject><subject>Ischemia</subject><subject>Ischemic Stroke</subject><subject>Lipopolysaccharides</subject><subject>Mice</subject><subject>Microglia</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - metabolism</subject><subject>NLR Family, Pyrin Domain-Containing 3 Protein - genetics</subject><subject>NLR Family, Pyrin Domain-Containing 3 Protein - metabolism</subject><subject>Occlusion</subject><subject>Oxygen</subject><subject>Pyrin protein</subject><subject>Recovery of function</subject><subject>Stroke</subject><subject>Stroke - drug therapy</subject><subject>Stroke - metabolism</subject><issn>2042-6496</issn><issn>2042-650X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkV1rFTEQhhdRbGl74w-QgDcibJuvTTaX5WhVOPSUUsG7JcnOHlOTzTHJFs8v8m8a-3Xh3Mww88zLDG_TvCH4lGCmzkY6RUy4FPpFc0gxp63o8PeXTzVX4qA5yfkW12BK9ap_3Rww0RHClDhs_mx-6tnNaEoxoFVMEHfZZVTcbEtMTqPLpZRTpL2HO6cLZGTjdnbF3QFyYaddCjAXVBWM83WetK9ECHFGVqdY3Ih0qu09itb6Jbs6CM4CMnuUYLvUHTdvUfkBtX3dyrPL9fUVQ_p3PcLdoyluvdPHzatJ-wwnj_mo-Xbx6Wb1pV1vPn9dna9by0hXWtDAJwNG9kbqXuuRE8ax6A0zAtTUAQZGR6O6ERMrBTXK9uM0SWEkHgXn7Kh5_6C7S_HXArkMwWUL3usZ4pIHKjuOuaJCVvTdf-htXNJcr6uUwKSjhOFKfXig6iM5J5iGXXJBp_1A8PDPweEjvdjcO3he4bePkosJMD6jT36xvwGFmTk</recordid><startdate>20230103</startdate><enddate>20230103</enddate><creator>Mi, Yan</creator><creator>Xu, Jikai</creator><creator>Shi, Ruijia</creator><creator>Meng, Qingqi</creator><creator>Xu, Libin</creator><creator>Liu, Yeshu</creator><creator>Guo, Tingting</creator><creator>Zhou, Di</creator><creator>Liu, Jingyu</creator><creator>Li, Wei</creator><creator>Li, Ning</creator><creator>Hou, Yue</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7T7</scope><scope>7TO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4143-8597</orcidid><orcidid>https://orcid.org/0000-0002-5028-0691</orcidid></search><sort><creationdate>20230103</creationdate><title>Okanin from Coreopsis tinctoria Nutt. alleviates cognitive impairment in bilateral common carotid artery occlusion mice by regulating the miR-7/NLRP3 axis in microglia</title><author>Mi, Yan ; Xu, Jikai ; Shi, Ruijia ; Meng, Qingqi ; Xu, Libin ; Liu, Yeshu ; Guo, Tingting ; Zhou, Di ; Liu, Jingyu ; Li, Wei ; Li, Ning ; Hou, Yue</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c315t-eae4fbeb78b7a8aad4134068b3b6e9f5e0e32db95d01c762b9c8dff76b70d6443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Animals</topic><topic>Beverages</topic><topic>Carotid arteries</topic><topic>Carotid artery</topic><topic>Carotid Artery, Common - metabolism</topic><topic>Cerebral blood flow</topic><topic>Cognitive ability</topic><topic>Cognitive Dysfunction - drug therapy</topic><topic>Cognitive Dysfunction - metabolism</topic><topic>Coreopsis</topic><topic>Coreopsis tinctoria</topic><topic>Deprivation</topic><topic>Food</topic><topic>Functional foods & nutraceuticals</topic><topic>Glucose</topic><topic>Impairment</topic><topic>Inflammasomes</topic><topic>Inflammasomes - metabolism</topic><topic>Inflammation</topic><topic>Inflammatory response</topic><topic>Ischemia</topic><topic>Ischemic Stroke</topic><topic>Lipopolysaccharides</topic><topic>Mice</topic><topic>Microglia</topic><topic>MicroRNAs - genetics</topic><topic>MicroRNAs - metabolism</topic><topic>NLR Family, Pyrin Domain-Containing 3 Protein - genetics</topic><topic>NLR Family, Pyrin Domain-Containing 3 Protein - metabolism</topic><topic>Occlusion</topic><topic>Oxygen</topic><topic>Pyrin protein</topic><topic>Recovery of function</topic><topic>Stroke</topic><topic>Stroke - drug therapy</topic><topic>Stroke - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mi, Yan</creatorcontrib><creatorcontrib>Xu, Jikai</creatorcontrib><creatorcontrib>Shi, Ruijia</creatorcontrib><creatorcontrib>Meng, Qingqi</creatorcontrib><creatorcontrib>Xu, Libin</creatorcontrib><creatorcontrib>Liu, Yeshu</creatorcontrib><creatorcontrib>Guo, Tingting</creatorcontrib><creatorcontrib>Zhou, Di</creatorcontrib><creatorcontrib>Liu, Jingyu</creatorcontrib><creatorcontrib>Li, Wei</creatorcontrib><creatorcontrib>Li, Ning</creatorcontrib><creatorcontrib>Hou, Yue</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Food & function</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mi, Yan</au><au>Xu, Jikai</au><au>Shi, Ruijia</au><au>Meng, Qingqi</au><au>Xu, Libin</au><au>Liu, Yeshu</au><au>Guo, Tingting</au><au>Zhou, Di</au><au>Liu, Jingyu</au><au>Li, Wei</au><au>Li, Ning</au><au>Hou, Yue</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Okanin from Coreopsis tinctoria Nutt. alleviates cognitive impairment in bilateral common carotid artery occlusion mice by regulating the miR-7/NLRP3 axis in microglia</atitle><jtitle>Food & function</jtitle><addtitle>Food Funct</addtitle><date>2023-01-03</date><risdate>2023</risdate><volume>14</volume><issue>1</issue><spage>369</spage><epage>387</epage><pages>369-387</pages><issn>2042-6496</issn><eissn>2042-650X</eissn><abstract>Cognitive impairment is the main clinical feature following stroke, and microglia-mediated inflammatory response is a major contributor to it.
Nutt., an edible chrysanthemum, is commonly used as a functional ingredient in healthcare beverages and food. Okanin, the main active ingredient of
Nutt. flower, inhibits microglial activation. However, the role of okanin in cognitive impairment following ischemic stroke is still unknown. In this study, we investigated the effect of okanin on ischemic stroke and its underlying mechanism both
and
. Okanin was found to attenuate cognitive impairment in bilateral common carotid artery occlusion (BCCAO) mice, inhibit neuronal loss and microglial activation, decrease NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome activation, and increase miR-7 expression. Okanin suppressed NLRP3 inflammasome activation in oxygen-glucose deprivation (OGD) and lipopolysaccharide (LPS)-stimulated microglia by increasing miR-7 expression and inhibited microglia-induced neuronal injury. This study provides new insights into the role of okanin in ischemic stroke and shows that the miR-7/NLRP3 axis plays an important role in mediating the beneficial effects of okanin on cerebral ischemia. These findings suggest that okanin has great potential as a functional food for stroke recovery.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>36511396</pmid><doi>10.1039/d2fo01476a</doi><tpages>19</tpages><orcidid>https://orcid.org/0000-0003-4143-8597</orcidid><orcidid>https://orcid.org/0000-0002-5028-0691</orcidid></addata></record> |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008- |
| subjects | Animals Beverages Carotid arteries Carotid artery Carotid Artery, Common - metabolism Cerebral blood flow Cognitive ability Cognitive Dysfunction - drug therapy Cognitive Dysfunction - metabolism Coreopsis Coreopsis tinctoria Deprivation Food Functional foods & nutraceuticals Glucose Impairment Inflammasomes Inflammasomes - metabolism Inflammation Inflammatory response Ischemia Ischemic Stroke Lipopolysaccharides Mice Microglia MicroRNAs - genetics MicroRNAs - metabolism NLR Family, Pyrin Domain-Containing 3 Protein - genetics NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Occlusion Oxygen Pyrin protein Recovery of function Stroke Stroke - drug therapy Stroke - metabolism |
| title | Okanin from Coreopsis tinctoria Nutt. alleviates cognitive impairment in bilateral common carotid artery occlusion mice by regulating the miR-7/NLRP3 axis in microglia |
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