Membrane-Active Nonivamide Derivatives as Effective Broad-Spectrum Antimicrobials: Rational Design, Synthesis, and Biological Evaluation

Antibiotic resistance is emerging as a “global public health concern”. To address the growing epidemic of multidrug-resistant pathogens, the development of novel antimicrobials is urgently needed. In this study, by biomimicking cationic antibacterial peptides, we designed and synthesized a series of...

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Veröffentlicht in:	Journal of medicinal chemistry 2022-12, Vol.65 (24), p.16754-16773
Hauptverfasser:	Cai, Qiongna, Yu, Qian, Liang, Wanxin, Li, Haizhou, Liu, Jiayong, Li, Hongxia, Chen, Yongzhi, Fang, Shanfang, Zhong, Rongcui, Liu, Shouping, Lin, Shuimu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Anti-Infective Agents Capsaicin Mice Microbial Sensitivity Tests Structure-Activity Relationship
Online-Zugang:	Volltext
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