Comparison of relaxant effects of nifedipine and NS11021 on isolated umbilical arteries of healthy and preeclamptic pregnant women
Potassium (K+) channel openers and calcium (Ca2+) channel blockers are currently used to treat acute severe hypertension in pregnancy. We aimed to investigate the vasorelaxant effect of NS11021, a potent and specific big-conductance Ca2+-activated K+ (BKCa) channel activator, and to compare it with...
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| Veröffentlicht in: | European journal of obstetrics & gynecology and reproductive biology 2023-01, Vol.280, p.168-173 |
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| container_title | European journal of obstetrics & gynecology and reproductive biology |
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| creator | Karadas, Baris Acar-Sahan, Selin Kantarci, Sercan Uysal, Nusret Horoz, Ersan Kaya-Temiz, Tijen |
| description | Potassium (K+) channel openers and calcium (Ca2+) channel blockers are currently used to treat acute severe hypertension in pregnancy. We aimed to investigate the vasorelaxant effect of NS11021, a potent and specific big-conductance Ca2+-activated K+ (BKCa) channel activator, and to compare it with the vasorelaxant effect of nifedipine on human umbilical arteries (HUAs) isolated from healthy and preeclamptic pregnants.
A total of 29 HUAs were isolated immediately after delivery from 14 healthy and 15 preeclamptic pregnant with severe features. The concentration-dependent relaxation responses were obtained to nifedipine and NS11021 on HUAs precontracted with endothelin-1 (ET-1) (10-8 M) in an isolated tissue bath.
Both nifedipine and NS11021 caused concentration-dependent relaxation responses in HUAs from healthy and preeclamptic pregnants. While the maximum responses (Emax) and pD2 values of nifedipine did not change significantly in both groups, the Emax and pD2 values of NS11021 were significantly decreased in the preeclampsia group (Emax ± SEM; %75.57 ± 4.53 and %43.75 ± 14.00 and pD2 ± SEM; 6.92 ± 0.26 and 5.24 ± 0.53 respectively, p |
| doi_str_mv | 10.1016/j.ejogrb.2022.12.009 |
| format | Article |
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A total of 29 HUAs were isolated immediately after delivery from 14 healthy and 15 preeclamptic pregnant with severe features. The concentration-dependent relaxation responses were obtained to nifedipine and NS11021 on HUAs precontracted with endothelin-1 (ET-1) (10-8 M) in an isolated tissue bath.
Both nifedipine and NS11021 caused concentration-dependent relaxation responses in HUAs from healthy and preeclamptic pregnants. While the maximum responses (Emax) and pD2 values of nifedipine did not change significantly in both groups, the Emax and pD2 values of NS11021 were significantly decreased in the preeclampsia group (Emax ± SEM; %75.57 ± 4.53 and %43.75 ± 14.00 and pD2 ± SEM; 6.92 ± 0.26 and 5.24 ± 0.53 respectively, p < 0.05). In addition, the pD2 value of NS11021 was not significantly different from that of nifedipine in the control group, but decreased significantly in the preeclampsia group (pD2 ± SEM 7.1 ± 0.41 and 5.2 ± 0.53, p < 0.05, respectively).
Efficacy and potency of NS11021 decreased in HUAs from preeclamptic pregnants. Also, NS11021 is less potent than nifedipine in the preeclampsia group. BKCa channels may have a role in the pathogenesis of preeclampsia, however, further experimental studies are needed to elucidate that.</description><identifier>ISSN: 0301-2115</identifier><identifier>EISSN: 1872-7654</identifier><identifier>DOI: 10.1016/j.ejogrb.2022.12.009</identifier><identifier>PMID: 36508854</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Ca2+-activated K+ channels ; Female ; Human umbilical artery ; Humans ; Nifedipine ; Nifedipine - pharmacology ; NS11021 ; Pre-Eclampsia - drug therapy ; Preeclampsia ; Pregnancy ; Pregnant Women ; Umbilical Arteries ; Vasodilator Agents - pharmacology</subject><ispartof>European journal of obstetrics & gynecology and reproductive biology, 2023-01, Vol.280, p.168-173</ispartof><rights>2022 Elsevier B.V.</rights><rights>Copyright © 2022 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-3ad60fdc8903c62f3e2c02698b797e9349b13a9727588ac63ec626e7a4cdd1de3</citedby><cites>FETCH-LOGICAL-c362t-3ad60fdc8903c62f3e2c02698b797e9349b13a9727588ac63ec626e7a4cdd1de3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ejogrb.2022.12.009$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3554,27933,27934,46004</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36508854$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Karadas, Baris</creatorcontrib><creatorcontrib>Acar-Sahan, Selin</creatorcontrib><creatorcontrib>Kantarci, Sercan</creatorcontrib><creatorcontrib>Uysal, Nusret</creatorcontrib><creatorcontrib>Horoz, Ersan</creatorcontrib><creatorcontrib>Kaya-Temiz, Tijen</creatorcontrib><title>Comparison of relaxant effects of nifedipine and NS11021 on isolated umbilical arteries of healthy and preeclamptic pregnant women</title><title>European journal of obstetrics & gynecology and reproductive biology</title><addtitle>Eur J Obstet Gynecol Reprod Biol</addtitle><description>Potassium (K+) channel openers and calcium (Ca2+) channel blockers are currently used to treat acute severe hypertension in pregnancy. We aimed to investigate the vasorelaxant effect of NS11021, a potent and specific big-conductance Ca2+-activated K+ (BKCa) channel activator, and to compare it with the vasorelaxant effect of nifedipine on human umbilical arteries (HUAs) isolated from healthy and preeclamptic pregnants.
A total of 29 HUAs were isolated immediately after delivery from 14 healthy and 15 preeclamptic pregnant with severe features. The concentration-dependent relaxation responses were obtained to nifedipine and NS11021 on HUAs precontracted with endothelin-1 (ET-1) (10-8 M) in an isolated tissue bath.
Both nifedipine and NS11021 caused concentration-dependent relaxation responses in HUAs from healthy and preeclamptic pregnants. While the maximum responses (Emax) and pD2 values of nifedipine did not change significantly in both groups, the Emax and pD2 values of NS11021 were significantly decreased in the preeclampsia group (Emax ± SEM; %75.57 ± 4.53 and %43.75 ± 14.00 and pD2 ± SEM; 6.92 ± 0.26 and 5.24 ± 0.53 respectively, p < 0.05). In addition, the pD2 value of NS11021 was not significantly different from that of nifedipine in the control group, but decreased significantly in the preeclampsia group (pD2 ± SEM 7.1 ± 0.41 and 5.2 ± 0.53, p < 0.05, respectively).
Efficacy and potency of NS11021 decreased in HUAs from preeclamptic pregnants. Also, NS11021 is less potent than nifedipine in the preeclampsia group. BKCa channels may have a role in the pathogenesis of preeclampsia, however, further experimental studies are needed to elucidate that.</description><subject>Ca2+-activated K+ channels</subject><subject>Female</subject><subject>Human umbilical artery</subject><subject>Humans</subject><subject>Nifedipine</subject><subject>Nifedipine - pharmacology</subject><subject>NS11021</subject><subject>Pre-Eclampsia - drug therapy</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>Pregnant Women</subject><subject>Umbilical Arteries</subject><subject>Vasodilator Agents - pharmacology</subject><issn>0301-2115</issn><issn>1872-7654</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1P7CAUhonR6Fz1HxjTpZtWPlrabkzMxI-bGF2oa0LhVJlQqNDx6tZfLnW8LmVDIO9z3pwHoSOCC4IJP10VsPJPoSsoprQgtMC43UIL0tQ0r3lVbqMFZpjklJBqD_2JcYXTYazdRXuMV7hpqnKBPpZ-GGUw0bvM91kAK9-kmzLoe1BTnP-c6UGb0TjIpNPZ7T0hmJIsAYmycgKdrYfOWKOkzWSYIBj4Ap9B2un5_YsaA4Cychgno-bHk5tb_vkB3AHa6aWNcPh976PHy4uH5XV-c3f1d3l-kyvG6ZQzqTnutWpazBSnPQOqMOVt09VtDS0r244w2da0rppGKs4gpTjUslRaEw1sH51s5o7Bv6whTmIwUYG10oFfR5HAEpd1U9IULTdRFXyMAXoxBjPI8C4IFrN9sRIb-2K2LwgVyX7Cjr8b1t0A-gf6rzsFzjYBSHu-GggiKgNOJb8h6Rbam98bPgGuZJkm</recordid><startdate>202301</startdate><enddate>202301</enddate><creator>Karadas, Baris</creator><creator>Acar-Sahan, Selin</creator><creator>Kantarci, Sercan</creator><creator>Uysal, Nusret</creator><creator>Horoz, Ersan</creator><creator>Kaya-Temiz, Tijen</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202301</creationdate><title>Comparison of relaxant effects of nifedipine and NS11021 on isolated umbilical arteries of healthy and preeclamptic pregnant women</title><author>Karadas, Baris ; Acar-Sahan, Selin ; Kantarci, Sercan ; Uysal, Nusret ; Horoz, Ersan ; Kaya-Temiz, Tijen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-3ad60fdc8903c62f3e2c02698b797e9349b13a9727588ac63ec626e7a4cdd1de3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Ca2+-activated K+ channels</topic><topic>Female</topic><topic>Human umbilical artery</topic><topic>Humans</topic><topic>Nifedipine</topic><topic>Nifedipine - pharmacology</topic><topic>NS11021</topic><topic>Pre-Eclampsia - drug therapy</topic><topic>Preeclampsia</topic><topic>Pregnancy</topic><topic>Pregnant Women</topic><topic>Umbilical Arteries</topic><topic>Vasodilator Agents - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karadas, Baris</creatorcontrib><creatorcontrib>Acar-Sahan, Selin</creatorcontrib><creatorcontrib>Kantarci, Sercan</creatorcontrib><creatorcontrib>Uysal, Nusret</creatorcontrib><creatorcontrib>Horoz, Ersan</creatorcontrib><creatorcontrib>Kaya-Temiz, Tijen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of obstetrics & gynecology and reproductive biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karadas, Baris</au><au>Acar-Sahan, Selin</au><au>Kantarci, Sercan</au><au>Uysal, Nusret</au><au>Horoz, Ersan</au><au>Kaya-Temiz, Tijen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of relaxant effects of nifedipine and NS11021 on isolated umbilical arteries of healthy and preeclamptic pregnant women</atitle><jtitle>European journal of obstetrics & gynecology and reproductive biology</jtitle><addtitle>Eur J Obstet Gynecol Reprod Biol</addtitle><date>2023-01</date><risdate>2023</risdate><volume>280</volume><spage>168</spage><epage>173</epage><pages>168-173</pages><issn>0301-2115</issn><eissn>1872-7654</eissn><abstract>Potassium (K+) channel openers and calcium (Ca2+) channel blockers are currently used to treat acute severe hypertension in pregnancy. We aimed to investigate the vasorelaxant effect of NS11021, a potent and specific big-conductance Ca2+-activated K+ (BKCa) channel activator, and to compare it with the vasorelaxant effect of nifedipine on human umbilical arteries (HUAs) isolated from healthy and preeclamptic pregnants.
A total of 29 HUAs were isolated immediately after delivery from 14 healthy and 15 preeclamptic pregnant with severe features. The concentration-dependent relaxation responses were obtained to nifedipine and NS11021 on HUAs precontracted with endothelin-1 (ET-1) (10-8 M) in an isolated tissue bath.
Both nifedipine and NS11021 caused concentration-dependent relaxation responses in HUAs from healthy and preeclamptic pregnants. While the maximum responses (Emax) and pD2 values of nifedipine did not change significantly in both groups, the Emax and pD2 values of NS11021 were significantly decreased in the preeclampsia group (Emax ± SEM; %75.57 ± 4.53 and %43.75 ± 14.00 and pD2 ± SEM; 6.92 ± 0.26 and 5.24 ± 0.53 respectively, p < 0.05). In addition, the pD2 value of NS11021 was not significantly different from that of nifedipine in the control group, but decreased significantly in the preeclampsia group (pD2 ± SEM 7.1 ± 0.41 and 5.2 ± 0.53, p < 0.05, respectively).
Efficacy and potency of NS11021 decreased in HUAs from preeclamptic pregnants. Also, NS11021 is less potent than nifedipine in the preeclampsia group. BKCa channels may have a role in the pathogenesis of preeclampsia, however, further experimental studies are needed to elucidate that.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>36508854</pmid><doi>10.1016/j.ejogrb.2022.12.009</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Ca2+-activated K+ channels Female Human umbilical artery Humans Nifedipine Nifedipine - pharmacology NS11021 Pre-Eclampsia - drug therapy Preeclampsia Pregnancy Pregnant Women Umbilical Arteries Vasodilator Agents - pharmacology |
| title | Comparison of relaxant effects of nifedipine and NS11021 on isolated umbilical arteries of healthy and preeclamptic pregnant women |
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