Association Between the Redox State of Human Serum Albumin and Exercise Capacity in Patients With Cardiac Disease
The redox state of human serum albumin (HSA) is reported to be an oxidative stress biomarker; however, its clinical use in cardiac disease has not yet been examined. This study aimed to investigate the relation between the redox state of HSA and exercise capacity, which is a robust prognostic factor...
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| Veröffentlicht in: | The American journal of cardiology 2023-02, Vol.189, p.56-60 |
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| creator | Ishimaru, Yo Adachi, Takuji Ashikawa, Hironobu Hori, Masaya Shimozato, Takashi Ohtake, Hiroshi Shimizu, Shinya Ueyama, Jun Yamada, Sumio |
| description | The redox state of human serum albumin (HSA) is reported to be an oxidative stress biomarker; however, its clinical use in cardiac disease has not yet been examined. This study aimed to investigate the relation between the redox state of HSA and exercise capacity, which is a robust prognostic factor, in patients with cardiovascular disease. This cross-sectional study included outpatients with cardiac disease. Exercise capacity was assessed by peak oxygen consumption (peakVO2) measured using symptom-limited cardiopulmonary exercise testing. The high-performance liquid chromatography postcolumn bromocresol green method was used to part HSA into human nonmercaptalbumin (oxidized form) and human mercaptalbumin (HMA, reduced form). The fraction of human mercaptalbumin found in HSA (f[HMA]) was calculated as an indicator of the redox state of HSA. The association between peakVO2 and f(HMA) was examined using the Spearman correlation coefficient and multivariate linear regression analysis. A total of 70 patients were included (median age 76 years; 44 men; median peakVO2 15.5 ml/kg/min). The f(HMA) was positively correlated with peakVO2 (r = 0.38, p |
| doi_str_mv | 10.1016/j.amjcard.2022.11.034 |
| format | Article |
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This study aimed to investigate the relation between the redox state of HSA and exercise capacity, which is a robust prognostic factor, in patients with cardiovascular disease. This cross-sectional study included outpatients with cardiac disease. Exercise capacity was assessed by peak oxygen consumption (peakVO2) measured using symptom-limited cardiopulmonary exercise testing. The high-performance liquid chromatography postcolumn bromocresol green method was used to part HSA into human nonmercaptalbumin (oxidized form) and human mercaptalbumin (HMA, reduced form). The fraction of human mercaptalbumin found in HSA (f[HMA]) was calculated as an indicator of the redox state of HSA. The association between peakVO2 and f(HMA) was examined using the Spearman correlation coefficient and multivariate linear regression analysis. A total of 70 patients were included (median age 76 years; 44 men; median peakVO2 15.5 ml/kg/min). The f(HMA) was positively correlated with peakVO2 (r = 0.38, p <0.01). Even after controlling for potential confounders, this association remained in the multivariate linear regression analysis (standardized beta = 0.24, p <0.05). We found a positive association between f(HMA) and peakVO2, independent of potential confounders in patients with cardiac disease, suggesting that f(HMA) may be a novel biomarker related to exercise capacity in cardiac disease. Longitudinal studies are required to further examine the prognostic capability of f(HMA), the responsiveness to clinical intervention, and the association between f(HMA) and cardiac disease.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/j.amjcard.2022.11.034</identifier><identifier>PMID: 36508763</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Albumin ; Biomarkers ; Blood pressure ; Cardiovascular diseases ; Coronary artery disease ; Correlation analysis ; Correlation coefficient ; Correlation coefficients ; Cross-Sectional Studies ; Disease ; Exercise Tolerance ; Heart Diseases ; High performance liquid chromatography ; Human serum albumin ; Humans ; Liquid chromatography ; Longitudinal studies ; Male ; Multivariate analysis ; Musculoskeletal system ; Oxidation-Reduction ; Oxidative stress ; Oxygen consumption ; Peptides ; Redox properties ; Regression analysis ; Serum albumin ; Serum Albumin, Human - metabolism</subject><ispartof>The American journal of cardiology, 2023-02, Vol.189, p.56-60</ispartof><rights>2022 Elsevier Inc.</rights><rights>Copyright © 2022 Elsevier Inc. All rights reserved.</rights><rights>2022. Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-c0757c05712913fbde469c20817bf7f2f15659873d7b60674f768ac856e54ab73</citedby><cites>FETCH-LOGICAL-c393t-c0757c05712913fbde469c20817bf7f2f15659873d7b60674f768ac856e54ab73</cites><orcidid>0000-0002-5629-6475</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2765317978?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000,64390,64392,64394,72474</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36508763$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ishimaru, Yo</creatorcontrib><creatorcontrib>Adachi, Takuji</creatorcontrib><creatorcontrib>Ashikawa, Hironobu</creatorcontrib><creatorcontrib>Hori, Masaya</creatorcontrib><creatorcontrib>Shimozato, Takashi</creatorcontrib><creatorcontrib>Ohtake, Hiroshi</creatorcontrib><creatorcontrib>Shimizu, Shinya</creatorcontrib><creatorcontrib>Ueyama, Jun</creatorcontrib><creatorcontrib>Yamada, Sumio</creatorcontrib><title>Association Between the Redox State of Human Serum Albumin and Exercise Capacity in Patients With Cardiac Disease</title><title>The American journal of cardiology</title><addtitle>Am J Cardiol</addtitle><description>The redox state of human serum albumin (HSA) is reported to be an oxidative stress biomarker; however, its clinical use in cardiac disease has not yet been examined. This study aimed to investigate the relation between the redox state of HSA and exercise capacity, which is a robust prognostic factor, in patients with cardiovascular disease. This cross-sectional study included outpatients with cardiac disease. Exercise capacity was assessed by peak oxygen consumption (peakVO2) measured using symptom-limited cardiopulmonary exercise testing. The high-performance liquid chromatography postcolumn bromocresol green method was used to part HSA into human nonmercaptalbumin (oxidized form) and human mercaptalbumin (HMA, reduced form). The fraction of human mercaptalbumin found in HSA (f[HMA]) was calculated as an indicator of the redox state of HSA. The association between peakVO2 and f(HMA) was examined using the Spearman correlation coefficient and multivariate linear regression analysis. A total of 70 patients were included (median age 76 years; 44 men; median peakVO2 15.5 ml/kg/min). The f(HMA) was positively correlated with peakVO2 (r = 0.38, p <0.01). Even after controlling for potential confounders, this association remained in the multivariate linear regression analysis (standardized beta = 0.24, p <0.05). We found a positive association between f(HMA) and peakVO2, independent of potential confounders in patients with cardiac disease, suggesting that f(HMA) may be a novel biomarker related to exercise capacity in cardiac disease. Longitudinal studies are required to further examine the prognostic capability of f(HMA), the responsiveness to clinical intervention, and the association between f(HMA) and cardiac disease.</description><subject>Aged</subject><subject>Albumin</subject><subject>Biomarkers</subject><subject>Blood pressure</subject><subject>Cardiovascular diseases</subject><subject>Coronary artery disease</subject><subject>Correlation analysis</subject><subject>Correlation coefficient</subject><subject>Correlation coefficients</subject><subject>Cross-Sectional Studies</subject><subject>Disease</subject><subject>Exercise Tolerance</subject><subject>Heart Diseases</subject><subject>High performance liquid chromatography</subject><subject>Human serum albumin</subject><subject>Humans</subject><subject>Liquid chromatography</subject><subject>Longitudinal studies</subject><subject>Male</subject><subject>Multivariate analysis</subject><subject>Musculoskeletal system</subject><subject>Oxidation-Reduction</subject><subject>Oxidative stress</subject><subject>Oxygen consumption</subject><subject>Peptides</subject><subject>Redox properties</subject><subject>Regression analysis</subject><subject>Serum albumin</subject><subject>Serum Albumin, Human - 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Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ishimaru, Yo</au><au>Adachi, Takuji</au><au>Ashikawa, Hironobu</au><au>Hori, Masaya</au><au>Shimozato, Takashi</au><au>Ohtake, Hiroshi</au><au>Shimizu, Shinya</au><au>Ueyama, Jun</au><au>Yamada, Sumio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association Between the Redox State of Human Serum Albumin and Exercise Capacity in Patients With Cardiac Disease</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>2023-02-15</date><risdate>2023</risdate><volume>189</volume><spage>56</spage><epage>60</epage><pages>56-60</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><abstract>The redox state of human serum albumin (HSA) is reported to be an oxidative stress biomarker; however, its clinical use in cardiac disease has not yet been examined. This study aimed to investigate the relation between the redox state of HSA and exercise capacity, which is a robust prognostic factor, in patients with cardiovascular disease. This cross-sectional study included outpatients with cardiac disease. Exercise capacity was assessed by peak oxygen consumption (peakVO2) measured using symptom-limited cardiopulmonary exercise testing. The high-performance liquid chromatography postcolumn bromocresol green method was used to part HSA into human nonmercaptalbumin (oxidized form) and human mercaptalbumin (HMA, reduced form). The fraction of human mercaptalbumin found in HSA (f[HMA]) was calculated as an indicator of the redox state of HSA. The association between peakVO2 and f(HMA) was examined using the Spearman correlation coefficient and multivariate linear regression analysis. A total of 70 patients were included (median age 76 years; 44 men; median peakVO2 15.5 ml/kg/min). The f(HMA) was positively correlated with peakVO2 (r = 0.38, p <0.01). Even after controlling for potential confounders, this association remained in the multivariate linear regression analysis (standardized beta = 0.24, p <0.05). We found a positive association between f(HMA) and peakVO2, independent of potential confounders in patients with cardiac disease, suggesting that f(HMA) may be a novel biomarker related to exercise capacity in cardiac disease. Longitudinal studies are required to further examine the prognostic capability of f(HMA), the responsiveness to clinical intervention, and the association between f(HMA) and cardiac disease.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>36508763</pmid><doi>10.1016/j.amjcard.2022.11.034</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-5629-6475</orcidid></addata></record> |
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| subjects | Aged Albumin Biomarkers Blood pressure Cardiovascular diseases Coronary artery disease Correlation analysis Correlation coefficient Correlation coefficients Cross-Sectional Studies Disease Exercise Tolerance Heart Diseases High performance liquid chromatography Human serum albumin Humans Liquid chromatography Longitudinal studies Male Multivariate analysis Musculoskeletal system Oxidation-Reduction Oxidative stress Oxygen consumption Peptides Redox properties Regression analysis Serum albumin Serum Albumin, Human - metabolism |
| title | Association Between the Redox State of Human Serum Albumin and Exercise Capacity in Patients With Cardiac Disease |
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