Long-term yogic intervention decreases serum interleukins IL-10 and IL-1β and improves cancer-related fatigue and functional scale during radiotherapy/chemotherapy in breast cancer patients: a randomized control study
Purpose Yoga improved fatigue and immunological profile in cancer survivors and has been a promising alternative therapy. Breast cancer treatments are rapidly improving, along with their side effects. This article investigated the effect of the yogic intervention at a different time interval during...
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| Veröffentlicht in: | Supportive care in cancer 2023-01, Vol.31 (1), p.6-6, Article 6 |
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| creator | Jain, Mayank Mishra, Archana Yadav, Vishnu Shyam, Hari Kumar, Shailendra Mishra, Satyendra Kumar Ramakant, Pooja |
| description | Purpose
Yoga improved fatigue and immunological profile in cancer survivors and has been a promising alternative therapy. Breast cancer treatments are rapidly improving, along with their side effects. This article investigated the effect of the yogic intervention at a different time interval during radiotherapy/chemotherapy on the pro- and anti-inflammatory interleukins along with the cancer-related fatigue and functional scale among patients with stage II/III breast cancer.
Methods
A total of 96 stage II/III breast cancer patients were enrolled in this study and randomly divided into two different groups. Group I (non-Yoga) received chemotherapy and/or radiotherapy and group II (Yoga) received an additional yogic intervention. Both groups were followed up for a period of 48 weeks and blood was collected at the time of enrollment, 16, 32, and 48 weeks, and serum was isolated to measure the pro- and anti-inflammatory interleukins, fatigue, and functional scale questionnaire obtained at each time point.
Results
Breast cancer patients in group II showed a significant improvement (
p
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| doi_str_mv | 10.1007/s00520-022-07487-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2754046884</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2753890192</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-16ae12a38117288187796532326e5989cb8d150e22d30e7042e3d8e4e036420c3</originalsourceid><addsrcrecordid>eNp9kctu1DAUhiMEokPhBVggS2zYmB5fEjvsUMWl0khsYB157DNTl8QOdlJpeCwepA_Qp8EzmYLEgpVt-TvfOfZfVS8ZvGUA6iID1BwocE5BSa2ofFStmBSCKiHax9UKWsmoFHV9Vj3L-QaAKVXzp9WZaGrGmYRVdb-OYUcnTAPZx523xIdyuMUw-RiIQ5vQZMwkY5qH5bLH-bsPmVytKQNigjvu7n4dt34YU7wtBdYEi4km7M2EjmzN5HczHpntHOxBb3qSremRuDn5sCPJOB-na0xm3F_YaxweDqUv2RwGmU5aMhZdmTG_I6aUBRcH_7N0sTFMKRbtNLv98-rJ1vQZX5zW8-rbxw9fLz_T9ZdPV5fv19QKVU-UNQYZN0IzprjWTCvVNrXggjdYt7q1G-1YDci5E4AKJEfhNEoE0UgOVpxXbxZvefmPGfPUDT5b7HsTMM6546qWIButZUFf_4PexDmVjzhSQrfAWl4ovlA2xZwTbrsx-cGkfcegOyTfLcl3JfnumHx3UL86qefNgO5PyUPUBRALkMfDb2P62_s_2t8TLrz6</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2753890192</pqid></control><display><type>article</type><title>Long-term yogic intervention decreases serum interleukins IL-10 and IL-1β and improves cancer-related fatigue and functional scale during radiotherapy/chemotherapy in breast cancer patients: a randomized control study</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Jain, Mayank ; Mishra, Archana ; Yadav, Vishnu ; Shyam, Hari ; Kumar, Shailendra ; Mishra, Satyendra Kumar ; Ramakant, Pooja</creator><creatorcontrib>Jain, Mayank ; Mishra, Archana ; Yadav, Vishnu ; Shyam, Hari ; Kumar, Shailendra ; Mishra, Satyendra Kumar ; Ramakant, Pooja</creatorcontrib><description>Purpose
Yoga improved fatigue and immunological profile in cancer survivors and has been a promising alternative therapy. Breast cancer treatments are rapidly improving, along with their side effects. This article investigated the effect of the yogic intervention at a different time interval during radiotherapy/chemotherapy on the pro- and anti-inflammatory interleukins along with the cancer-related fatigue and functional scale among patients with stage II/III breast cancer.
Methods
A total of 96 stage II/III breast cancer patients were enrolled in this study and randomly divided into two different groups. Group I (non-Yoga) received chemotherapy and/or radiotherapy and group II (Yoga) received an additional yogic intervention. Both groups were followed up for a period of 48 weeks and blood was collected at the time of enrollment, 16, 32, and 48 weeks, and serum was isolated to measure the pro- and anti-inflammatory interleukins, fatigue, and functional scale questionnaire obtained at each time point.
Results
Breast cancer patients in group II showed a significant improvement (
p
< 0.05) in the functional scale and fatigue from baseline to 48 weeks compared to group I. The yogic intervention significantly decreased (
p
< 0.05) the level of pro-inflammatory interleukin IL-1β and pleiotropic interleukin IL-10 in group II compared to group I.
Conclusion
These finding suggested that improved fatigue and functional scale is associated with a lower level of IL-1β and IL-10. Yoga may be an important additional therapy along with the cancer treatment to help the patients with cancer-related fatigue and improve their overall immunological profile.</description><identifier>ISSN: 0941-4355</identifier><identifier>EISSN: 1433-7339</identifier><identifier>DOI: 10.1007/s00520-022-07487-4</identifier><identifier>PMID: 36512140</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Breast cancer ; Breast Neoplasms - complications ; Breast Neoplasms - drug therapy ; Breast Neoplasms - radiotherapy ; Cancer therapies ; Chemotherapy ; Clinical trials ; Cytokines ; Fatigue - etiology ; Fatigue - therapy ; Female ; Humans ; Immunology ; Interleukin-10 - blood ; Medicine ; Medicine & Public Health ; Nursing ; Nursing Research ; Oncology ; Pain Medicine ; Quality of Life ; Radiation therapy ; Rehabilitation Medicine ; Yoga</subject><ispartof>Supportive care in cancer, 2023-01, Vol.31 (1), p.6-6, Article 6</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-16ae12a38117288187796532326e5989cb8d150e22d30e7042e3d8e4e036420c3</citedby><cites>FETCH-LOGICAL-c375t-16ae12a38117288187796532326e5989cb8d150e22d30e7042e3d8e4e036420c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00520-022-07487-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00520-022-07487-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36512140$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jain, Mayank</creatorcontrib><creatorcontrib>Mishra, Archana</creatorcontrib><creatorcontrib>Yadav, Vishnu</creatorcontrib><creatorcontrib>Shyam, Hari</creatorcontrib><creatorcontrib>Kumar, Shailendra</creatorcontrib><creatorcontrib>Mishra, Satyendra Kumar</creatorcontrib><creatorcontrib>Ramakant, Pooja</creatorcontrib><title>Long-term yogic intervention decreases serum interleukins IL-10 and IL-1β and improves cancer-related fatigue and functional scale during radiotherapy/chemotherapy in breast cancer patients: a randomized control study</title><title>Supportive care in cancer</title><addtitle>Support Care Cancer</addtitle><addtitle>Support Care Cancer</addtitle><description>Purpose
Yoga improved fatigue and immunological profile in cancer survivors and has been a promising alternative therapy. Breast cancer treatments are rapidly improving, along with their side effects. This article investigated the effect of the yogic intervention at a different time interval during radiotherapy/chemotherapy on the pro- and anti-inflammatory interleukins along with the cancer-related fatigue and functional scale among patients with stage II/III breast cancer.
Methods
A total of 96 stage II/III breast cancer patients were enrolled in this study and randomly divided into two different groups. Group I (non-Yoga) received chemotherapy and/or radiotherapy and group II (Yoga) received an additional yogic intervention. Both groups were followed up for a period of 48 weeks and blood was collected at the time of enrollment, 16, 32, and 48 weeks, and serum was isolated to measure the pro- and anti-inflammatory interleukins, fatigue, and functional scale questionnaire obtained at each time point.
Results
Breast cancer patients in group II showed a significant improvement (
p
< 0.05) in the functional scale and fatigue from baseline to 48 weeks compared to group I. The yogic intervention significantly decreased (
p
< 0.05) the level of pro-inflammatory interleukin IL-1β and pleiotropic interleukin IL-10 in group II compared to group I.
Conclusion
These finding suggested that improved fatigue and functional scale is associated with a lower level of IL-1β and IL-10. Yoga may be an important additional therapy along with the cancer treatment to help the patients with cancer-related fatigue and improve their overall immunological profile.</description><subject>Breast cancer</subject><subject>Breast Neoplasms - complications</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Breast Neoplasms - radiotherapy</subject><subject>Cancer therapies</subject><subject>Chemotherapy</subject><subject>Clinical trials</subject><subject>Cytokines</subject><subject>Fatigue - etiology</subject><subject>Fatigue - therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Immunology</subject><subject>Interleukin-10 - blood</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nursing</subject><subject>Nursing Research</subject><subject>Oncology</subject><subject>Pain Medicine</subject><subject>Quality of Life</subject><subject>Radiation therapy</subject><subject>Rehabilitation Medicine</subject><subject>Yoga</subject><issn>0941-4355</issn><issn>1433-7339</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kctu1DAUhiMEokPhBVggS2zYmB5fEjvsUMWl0khsYB157DNTl8QOdlJpeCwepA_Qp8EzmYLEgpVt-TvfOfZfVS8ZvGUA6iID1BwocE5BSa2ofFStmBSCKiHax9UKWsmoFHV9Vj3L-QaAKVXzp9WZaGrGmYRVdb-OYUcnTAPZx523xIdyuMUw-RiIQ5vQZMwkY5qH5bLH-bsPmVytKQNigjvu7n4dt34YU7wtBdYEi4km7M2EjmzN5HczHpntHOxBb3qSremRuDn5sCPJOB-na0xm3F_YaxweDqUv2RwGmU5aMhZdmTG_I6aUBRcH_7N0sTFMKRbtNLv98-rJ1vQZX5zW8-rbxw9fLz_T9ZdPV5fv19QKVU-UNQYZN0IzprjWTCvVNrXggjdYt7q1G-1YDci5E4AKJEfhNEoE0UgOVpxXbxZvefmPGfPUDT5b7HsTMM6546qWIButZUFf_4PexDmVjzhSQrfAWl4ovlA2xZwTbrsx-cGkfcegOyTfLcl3JfnumHx3UL86qefNgO5PyUPUBRALkMfDb2P62_s_2t8TLrz6</recordid><startdate>20230101</startdate><enddate>20230101</enddate><creator>Jain, Mayank</creator><creator>Mishra, Archana</creator><creator>Yadav, Vishnu</creator><creator>Shyam, Hari</creator><creator>Kumar, Shailendra</creator><creator>Mishra, Satyendra Kumar</creator><creator>Ramakant, Pooja</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88J</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HEHIP</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2R</scope><scope>M2S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20230101</creationdate><title>Long-term yogic intervention decreases serum interleukins IL-10 and IL-1β and improves cancer-related fatigue and functional scale during radiotherapy/chemotherapy in breast cancer patients: a randomized control study</title><author>Jain, Mayank ; Mishra, Archana ; Yadav, Vishnu ; Shyam, Hari ; Kumar, Shailendra ; Mishra, Satyendra Kumar ; Ramakant, Pooja</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-16ae12a38117288187796532326e5989cb8d150e22d30e7042e3d8e4e036420c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Breast cancer</topic><topic>Breast Neoplasms - complications</topic><topic>Breast Neoplasms - drug therapy</topic><topic>Breast Neoplasms - radiotherapy</topic><topic>Cancer therapies</topic><topic>Chemotherapy</topic><topic>Clinical trials</topic><topic>Cytokines</topic><topic>Fatigue - etiology</topic><topic>Fatigue - therapy</topic><topic>Female</topic><topic>Humans</topic><topic>Immunology</topic><topic>Interleukin-10 - blood</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nursing</topic><topic>Nursing Research</topic><topic>Oncology</topic><topic>Pain Medicine</topic><topic>Quality of Life</topic><topic>Radiation therapy</topic><topic>Rehabilitation Medicine</topic><topic>Yoga</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jain, Mayank</creatorcontrib><creatorcontrib>Mishra, Archana</creatorcontrib><creatorcontrib>Yadav, Vishnu</creatorcontrib><creatorcontrib>Shyam, Hari</creatorcontrib><creatorcontrib>Kumar, Shailendra</creatorcontrib><creatorcontrib>Mishra, Satyendra Kumar</creatorcontrib><creatorcontrib>Ramakant, Pooja</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Sociology Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Social Science Database</collection><collection>Sociology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Supportive care in cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jain, Mayank</au><au>Mishra, Archana</au><au>Yadav, Vishnu</au><au>Shyam, Hari</au><au>Kumar, Shailendra</au><au>Mishra, Satyendra Kumar</au><au>Ramakant, Pooja</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-term yogic intervention decreases serum interleukins IL-10 and IL-1β and improves cancer-related fatigue and functional scale during radiotherapy/chemotherapy in breast cancer patients: a randomized control study</atitle><jtitle>Supportive care in cancer</jtitle><stitle>Support Care Cancer</stitle><addtitle>Support Care Cancer</addtitle><date>2023-01-01</date><risdate>2023</risdate><volume>31</volume><issue>1</issue><spage>6</spage><epage>6</epage><pages>6-6</pages><artnum>6</artnum><issn>0941-4355</issn><eissn>1433-7339</eissn><abstract>Purpose
Yoga improved fatigue and immunological profile in cancer survivors and has been a promising alternative therapy. Breast cancer treatments are rapidly improving, along with their side effects. This article investigated the effect of the yogic intervention at a different time interval during radiotherapy/chemotherapy on the pro- and anti-inflammatory interleukins along with the cancer-related fatigue and functional scale among patients with stage II/III breast cancer.
Methods
A total of 96 stage II/III breast cancer patients were enrolled in this study and randomly divided into two different groups. Group I (non-Yoga) received chemotherapy and/or radiotherapy and group II (Yoga) received an additional yogic intervention. Both groups were followed up for a period of 48 weeks and blood was collected at the time of enrollment, 16, 32, and 48 weeks, and serum was isolated to measure the pro- and anti-inflammatory interleukins, fatigue, and functional scale questionnaire obtained at each time point.
Results
Breast cancer patients in group II showed a significant improvement (
p
< 0.05) in the functional scale and fatigue from baseline to 48 weeks compared to group I. The yogic intervention significantly decreased (
p
< 0.05) the level of pro-inflammatory interleukin IL-1β and pleiotropic interleukin IL-10 in group II compared to group I.
Conclusion
These finding suggested that improved fatigue and functional scale is associated with a lower level of IL-1β and IL-10. Yoga may be an important additional therapy along with the cancer treatment to help the patients with cancer-related fatigue and improve their overall immunological profile.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>36512140</pmid><doi>10.1007/s00520-022-07487-4</doi><tpages>1</tpages></addata></record> |
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| subjects | Breast cancer Breast Neoplasms - complications Breast Neoplasms - drug therapy Breast Neoplasms - radiotherapy Cancer therapies Chemotherapy Clinical trials Cytokines Fatigue - etiology Fatigue - therapy Female Humans Immunology Interleukin-10 - blood Medicine Medicine & Public Health Nursing Nursing Research Oncology Pain Medicine Quality of Life Radiation therapy Rehabilitation Medicine Yoga |
| title | Long-term yogic intervention decreases serum interleukins IL-10 and IL-1β and improves cancer-related fatigue and functional scale during radiotherapy/chemotherapy in breast cancer patients: a randomized control study |
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