Dressing to prevent surgical site infection in adult patients with cancer: a systematic review with meta-analysis
Purpose To identify the most effective dressing for application to surgical wounds with primary closure to prevent surgical site infection (SSI) in adult patients with cancer undergoing elective surgeries. Methods This systematic review was based on the Preferred Reporting Items for Systematic Rev...
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Veröffentlicht in: | Supportive care in cancer 2023-01, Vol.31 (1), p.11-11, Article 11 |
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description |
Purpose
To identify the most effective dressing for application to surgical wounds with primary closure to prevent surgical site infection (SSI) in adult patients with cancer undergoing elective surgeries.
Methods
This systematic review was based on the
Preferred Reporting Items for Systematic Reviews and Meta-Analysis
, with online searches conducted in the CINHAL, Cochrane Central, LILACS, PubMed, Scopus, Embase, Livivo, and Web of Science databases. An additional search was conducted in gray literature using Google Scholar. The risk of bias was assessed using RoB 2.0. The certainty of evidence was evaluated using the
Grading of Recommendations Assessment
and
Development and Evaluation
, and the results were synthesized in a descriptive manner and using meta-analysis.
Results
Eleven randomized clinical trials were conducted to compare different types of dressing—silver dressing with absorbent dressing (
n
= 3), mupirocin dressing with paraffin/no dressing (
n
= 1), honey-based dressing with absorbent dressing (
n
= 1), vitamin E and silicone-containing dressing with absorbent dressing (
n
= 1), and negative pressure wound therapy with absorbent dressing (
n
= 4)—and compare the usage duration of absorbent dressing (
n
= 1). Nine trials presented a low risk of bias, and two were classified as having uncertain bias. Compared with absorbent dressing, silver dressing did not reduce the risk of developing any type of SSI in 894 clinical trial participants (risk relative RR: 0.72; 95% confidence interval [CI] [0.44, 1.17]
p
= 0.18). Compared with absorbent dressing, negative pressure wound therapy did not reduce the risk of developing any type of SSI in the 1041 participants of two clinical trials (RR 0.68; 95% CI [0.31, 1.26]
p
= 0.22). The certainty of evidence of the three meta-analyses was considered low or very low for the prevention of SSI. We believe that this low certainty of evidence can be improved by conducting new studies in the future.
Conclusion
There is no evidence regarding which dressing is the most effective in preventing SSI in adult patients with cancer. |
doi_str_mv | 10.1007/s00520-022-07467-8 |
format | Article |
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Purpose
To identify the most effective dressing for application to surgical wounds with primary closure to prevent surgical site infection (SSI) in adult patients with cancer undergoing elective surgeries.
Methods
This systematic review was based on the
Preferred Reporting Items for Systematic Reviews and Meta-Analysis
, with online searches conducted in the CINHAL, Cochrane Central, LILACS, PubMed, Scopus, Embase, Livivo, and Web of Science databases. An additional search was conducted in gray literature using Google Scholar. The risk of bias was assessed using RoB 2.0. The certainty of evidence was evaluated using the
Grading of Recommendations Assessment
and
Development and Evaluation
, and the results were synthesized in a descriptive manner and using meta-analysis.
Results
Eleven randomized clinical trials were conducted to compare different types of dressing—silver dressing with absorbent dressing (
n
= 3), mupirocin dressing with paraffin/no dressing (
n
= 1), honey-based dressing with absorbent dressing (
n
= 1), vitamin E and silicone-containing dressing with absorbent dressing (
n
= 1), and negative pressure wound therapy with absorbent dressing (
n
= 4)—and compare the usage duration of absorbent dressing (
n
= 1). Nine trials presented a low risk of bias, and two were classified as having uncertain bias. Compared with absorbent dressing, silver dressing did not reduce the risk of developing any type of SSI in 894 clinical trial participants (risk relative RR: 0.72; 95% confidence interval [CI] [0.44, 1.17]
p
= 0.18). Compared with absorbent dressing, negative pressure wound therapy did not reduce the risk of developing any type of SSI in the 1041 participants of two clinical trials (RR 0.68; 95% CI [0.31, 1.26]
p
= 0.22). The certainty of evidence of the three meta-analyses was considered low or very low for the prevention of SSI. We believe that this low certainty of evidence can be improved by conducting new studies in the future.
Conclusion
There is no evidence regarding which dressing is the most effective in preventing SSI in adult patients with cancer.</description><identifier>ISSN: 0941-4355</identifier><identifier>EISSN: 1433-7339</identifier><identifier>DOI: 10.1007/s00520-022-07467-8</identifier><identifier>PMID: 36512091</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Analysis ; Cancer ; Cancer patients ; Cancer surgery ; Clinical trials ; Database searching ; Disease prevention ; Health aspects ; Infection ; Infection control ; Internet/Web search services ; Medical dressings ; Medicine ; Medicine & Public Health ; Meta-analysis ; Mupirocin ; Nursing ; Nursing Research ; Oncology ; Online databases ; Online searching ; Pain Medicine ; Prevention ; Rehabilitation Medicine ; Review ; Surgery ; Surgical site infections ; Systematic review ; Wound healing</subject><ispartof>Supportive care in cancer, 2023-01, Vol.31 (1), p.11-11, Article 11</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>COPYRIGHT 2023 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-78ec502a18a23a7e2e61b0c431f54ccedb5ce14e6e2c0234f685336b7f7cf6f03</citedby><cites>FETCH-LOGICAL-c372t-78ec502a18a23a7e2e61b0c431f54ccedb5ce14e6e2c0234f685336b7f7cf6f03</cites><orcidid>0000-0002-7601-3399 ; 0000-0002-1939-6194 ; 0000-0002-2883-3640 ; 0000-0002-1006-9357 ; 0000-0002-9363-0057 ; 0000-0002-9782-3366</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00520-022-07467-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00520-022-07467-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27911,27912,41475,42544,51306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36512091$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dias, Thais Almeida</creatorcontrib><creatorcontrib>Fernandes, Daiane Rubinato</creatorcontrib><creatorcontrib>dos Santos, Bruna Nogueira</creatorcontrib><creatorcontrib>dos Reis, Paula Elaine Diniz</creatorcontrib><creatorcontrib>Margatho, Amanda Salles</creatorcontrib><creatorcontrib>Silveira, Renata Cristina de Campos Pereira</creatorcontrib><title>Dressing to prevent surgical site infection in adult patients with cancer: a systematic review with meta-analysis</title><title>Supportive care in cancer</title><addtitle>Support Care Cancer</addtitle><addtitle>Support Care Cancer</addtitle><description>
Purpose
To identify the most effective dressing for application to surgical wounds with primary closure to prevent surgical site infection (SSI) in adult patients with cancer undergoing elective surgeries.
Methods
This systematic review was based on the
Preferred Reporting Items for Systematic Reviews and Meta-Analysis
, with online searches conducted in the CINHAL, Cochrane Central, LILACS, PubMed, Scopus, Embase, Livivo, and Web of Science databases. An additional search was conducted in gray literature using Google Scholar. The risk of bias was assessed using RoB 2.0. The certainty of evidence was evaluated using the
Grading of Recommendations Assessment
and
Development and Evaluation
, and the results were synthesized in a descriptive manner and using meta-analysis.
Results
Eleven randomized clinical trials were conducted to compare different types of dressing—silver dressing with absorbent dressing (
n
= 3), mupirocin dressing with paraffin/no dressing (
n
= 1), honey-based dressing with absorbent dressing (
n
= 1), vitamin E and silicone-containing dressing with absorbent dressing (
n
= 1), and negative pressure wound therapy with absorbent dressing (
n
= 4)—and compare the usage duration of absorbent dressing (
n
= 1). Nine trials presented a low risk of bias, and two were classified as having uncertain bias. Compared with absorbent dressing, silver dressing did not reduce the risk of developing any type of SSI in 894 clinical trial participants (risk relative RR: 0.72; 95% confidence interval [CI] [0.44, 1.17]
p
= 0.18). Compared with absorbent dressing, negative pressure wound therapy did not reduce the risk of developing any type of SSI in the 1041 participants of two clinical trials (RR 0.68; 95% CI [0.31, 1.26]
p
= 0.22). The certainty of evidence of the three meta-analyses was considered low or very low for the prevention of SSI. We believe that this low certainty of evidence can be improved by conducting new studies in the future.
Conclusion
There is no evidence regarding which dressing is the most effective in preventing SSI in adult patients with cancer.</description><subject>Analysis</subject><subject>Cancer</subject><subject>Cancer patients</subject><subject>Cancer surgery</subject><subject>Clinical trials</subject><subject>Database searching</subject><subject>Disease prevention</subject><subject>Health aspects</subject><subject>Infection</subject><subject>Infection control</subject><subject>Internet/Web search services</subject><subject>Medical dressings</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Meta-analysis</subject><subject>Mupirocin</subject><subject>Nursing</subject><subject>Nursing Research</subject><subject>Oncology</subject><subject>Online databases</subject><subject>Online searching</subject><subject>Pain Medicine</subject><subject>Prevention</subject><subject>Rehabilitation Medicine</subject><subject>Review</subject><subject>Surgery</subject><subject>Surgical site infections</subject><subject>Systematic review</subject><subject>Wound healing</subject><issn>0941-4355</issn><issn>1433-7339</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kc1rFTEUxYNY7LP6D7iQgBs30958TWbclapVKLjRdcjLu_NMmY_X3EzL--9NO7VFKSWLhNzfOZzkMPZOwLEAsCcEYCRUIGUFVte2al6wldBKVVap9iVbQatFpZUxh-w10SWAsNbIV-xQ1UZIaMWKXX1OSBTHLc8T3yW8xjFzmtM2Bt9zihl5HDsMOU5jOXG_mfvMdz7HAhK_ifk3D34MmD5xz2lPGYcyDLxYRbxZgAGzr_zo-z1FesMOOt8Tvr3fj9ivr19-nn2rLn6cfz87vaiCsjJXtsFgQHrReKm8RYm1WEPQSnRGh4CbtQkoNNYoA0ilu7oxStVr29nQ1R2oI_Zx8d2l6WpGym6IFLDv_YjTTE5ao0HXtZUF_fAfejnNqeS9o1TTgtbikdr6Hl35lSknH25N3alVAFByt4U6foIqa4NDDNOIXSz3_wjkIghpIkrYuV2Kg097J8Dd9uyWnl3p2d317Joien-feF4PuHmQ_C22AGoBqIzGLabHJz1j-wcohbJ5</recordid><startdate>20230101</startdate><enddate>20230101</enddate><creator>Dias, Thais Almeida</creator><creator>Fernandes, Daiane Rubinato</creator><creator>dos Santos, Bruna Nogueira</creator><creator>dos Reis, Paula Elaine Diniz</creator><creator>Margatho, Amanda Salles</creator><creator>Silveira, Renata Cristina de Campos Pereira</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88J</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HEHIP</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2R</scope><scope>M2S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7601-3399</orcidid><orcidid>https://orcid.org/0000-0002-1939-6194</orcidid><orcidid>https://orcid.org/0000-0002-2883-3640</orcidid><orcidid>https://orcid.org/0000-0002-1006-9357</orcidid><orcidid>https://orcid.org/0000-0002-9363-0057</orcidid><orcidid>https://orcid.org/0000-0002-9782-3366</orcidid></search><sort><creationdate>20230101</creationdate><title>Dressing to prevent surgical site infection in adult patients with cancer: a systematic review with meta-analysis</title><author>Dias, Thais Almeida ; Fernandes, Daiane Rubinato ; dos Santos, Bruna Nogueira ; dos Reis, Paula Elaine Diniz ; Margatho, Amanda Salles ; Silveira, Renata Cristina de Campos Pereira</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-78ec502a18a23a7e2e61b0c431f54ccedb5ce14e6e2c0234f685336b7f7cf6f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Analysis</topic><topic>Cancer</topic><topic>Cancer patients</topic><topic>Cancer surgery</topic><topic>Clinical trials</topic><topic>Database searching</topic><topic>Disease prevention</topic><topic>Health aspects</topic><topic>Infection</topic><topic>Infection control</topic><topic>Internet/Web search services</topic><topic>Medical dressings</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Meta-analysis</topic><topic>Mupirocin</topic><topic>Nursing</topic><topic>Nursing Research</topic><topic>Oncology</topic><topic>Online databases</topic><topic>Online searching</topic><topic>Pain Medicine</topic><topic>Prevention</topic><topic>Rehabilitation Medicine</topic><topic>Review</topic><topic>Surgery</topic><topic>Surgical site infections</topic><topic>Systematic review</topic><topic>Wound healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dias, Thais Almeida</creatorcontrib><creatorcontrib>Fernandes, Daiane Rubinato</creatorcontrib><creatorcontrib>dos Santos, Bruna Nogueira</creatorcontrib><creatorcontrib>dos Reis, Paula Elaine Diniz</creatorcontrib><creatorcontrib>Margatho, Amanda Salles</creatorcontrib><creatorcontrib>Silveira, Renata Cristina de Campos Pereira</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Sociology Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Social Science Database</collection><collection>Sociology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Supportive care in cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dias, Thais Almeida</au><au>Fernandes, Daiane Rubinato</au><au>dos Santos, Bruna Nogueira</au><au>dos Reis, Paula Elaine Diniz</au><au>Margatho, Amanda Salles</au><au>Silveira, Renata Cristina de Campos Pereira</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dressing to prevent surgical site infection in adult patients with cancer: a systematic review with meta-analysis</atitle><jtitle>Supportive care in cancer</jtitle><stitle>Support Care Cancer</stitle><addtitle>Support Care Cancer</addtitle><date>2023-01-01</date><risdate>2023</risdate><volume>31</volume><issue>1</issue><spage>11</spage><epage>11</epage><pages>11-11</pages><artnum>11</artnum><issn>0941-4355</issn><eissn>1433-7339</eissn><abstract>
Purpose
To identify the most effective dressing for application to surgical wounds with primary closure to prevent surgical site infection (SSI) in adult patients with cancer undergoing elective surgeries.
Methods
This systematic review was based on the
Preferred Reporting Items for Systematic Reviews and Meta-Analysis
, with online searches conducted in the CINHAL, Cochrane Central, LILACS, PubMed, Scopus, Embase, Livivo, and Web of Science databases. An additional search was conducted in gray literature using Google Scholar. The risk of bias was assessed using RoB 2.0. The certainty of evidence was evaluated using the
Grading of Recommendations Assessment
and
Development and Evaluation
, and the results were synthesized in a descriptive manner and using meta-analysis.
Results
Eleven randomized clinical trials were conducted to compare different types of dressing—silver dressing with absorbent dressing (
n
= 3), mupirocin dressing with paraffin/no dressing (
n
= 1), honey-based dressing with absorbent dressing (
n
= 1), vitamin E and silicone-containing dressing with absorbent dressing (
n
= 1), and negative pressure wound therapy with absorbent dressing (
n
= 4)—and compare the usage duration of absorbent dressing (
n
= 1). Nine trials presented a low risk of bias, and two were classified as having uncertain bias. Compared with absorbent dressing, silver dressing did not reduce the risk of developing any type of SSI in 894 clinical trial participants (risk relative RR: 0.72; 95% confidence interval [CI] [0.44, 1.17]
p
= 0.18). Compared with absorbent dressing, negative pressure wound therapy did not reduce the risk of developing any type of SSI in the 1041 participants of two clinical trials (RR 0.68; 95% CI [0.31, 1.26]
p
= 0.22). The certainty of evidence of the three meta-analyses was considered low or very low for the prevention of SSI. We believe that this low certainty of evidence can be improved by conducting new studies in the future.
Conclusion
There is no evidence regarding which dressing is the most effective in preventing SSI in adult patients with cancer.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>36512091</pmid><doi>10.1007/s00520-022-07467-8</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-7601-3399</orcidid><orcidid>https://orcid.org/0000-0002-1939-6194</orcidid><orcidid>https://orcid.org/0000-0002-2883-3640</orcidid><orcidid>https://orcid.org/0000-0002-1006-9357</orcidid><orcidid>https://orcid.org/0000-0002-9363-0057</orcidid><orcidid>https://orcid.org/0000-0002-9782-3366</orcidid></addata></record> |
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source | Springer Nature - Complete Springer Journals |
subjects | Analysis Cancer Cancer patients Cancer surgery Clinical trials Database searching Disease prevention Health aspects Infection Infection control Internet/Web search services Medical dressings Medicine Medicine & Public Health Meta-analysis Mupirocin Nursing Nursing Research Oncology Online databases Online searching Pain Medicine Prevention Rehabilitation Medicine Review Surgery Surgical site infections Systematic review Wound healing |
title | Dressing to prevent surgical site infection in adult patients with cancer: a systematic review with meta-analysis |
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