Dressing to prevent surgical site infection in adult patients with cancer: a systematic review with meta-analysis

  Purpose To identify the most effective dressing for application to surgical wounds with primary closure to prevent surgical site infection (SSI) in adult patients with cancer undergoing elective surgeries. Methods This systematic review was based on the Preferred Reporting Items for Systematic Rev...

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Veröffentlicht in:Supportive care in cancer 2023-01, Vol.31 (1), p.11-11, Article 11
Hauptverfasser: Dias, Thais Almeida, Fernandes, Daiane Rubinato, dos Santos, Bruna Nogueira, dos Reis, Paula Elaine Diniz, Margatho, Amanda Salles, Silveira, Renata Cristina de Campos Pereira
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container_end_page 11
container_issue 1
container_start_page 11
container_title Supportive care in cancer
container_volume 31
creator Dias, Thais Almeida
Fernandes, Daiane Rubinato
dos Santos, Bruna Nogueira
dos Reis, Paula Elaine Diniz
Margatho, Amanda Salles
Silveira, Renata Cristina de Campos Pereira
description   Purpose To identify the most effective dressing for application to surgical wounds with primary closure to prevent surgical site infection (SSI) in adult patients with cancer undergoing elective surgeries. Methods This systematic review was based on the Preferred Reporting Items for Systematic Reviews and Meta-Analysis , with online searches conducted in the CINHAL, Cochrane Central, LILACS, PubMed, Scopus, Embase, Livivo, and Web of Science databases. An additional search was conducted in gray literature using Google Scholar. The risk of bias was assessed using RoB 2.0. The certainty of evidence was evaluated using the Grading of Recommendations Assessment and Development and Evaluation , and the results were synthesized in a descriptive manner and using meta-analysis. Results Eleven randomized clinical trials were conducted to compare different types of dressing—silver dressing with absorbent dressing ( n  = 3), mupirocin dressing with paraffin/no dressing ( n  = 1), honey-based dressing with absorbent dressing ( n  = 1), vitamin E and silicone-containing dressing with absorbent dressing ( n  = 1), and negative pressure wound therapy with absorbent dressing ( n  = 4)—and compare the usage duration of absorbent dressing ( n  = 1). Nine trials presented a low risk of bias, and two were classified as having uncertain bias. Compared with absorbent dressing, silver dressing did not reduce the risk of developing any type of SSI in 894 clinical trial participants (risk relative RR: 0.72; 95% confidence interval [CI] [0.44, 1.17] p  = 0.18). Compared with absorbent dressing, negative pressure wound therapy did not reduce the risk of developing any type of SSI in the 1041 participants of two clinical trials (RR 0.68; 95% CI [0.31, 1.26] p  = 0.22). The certainty of evidence of the three meta-analyses was considered low or very low for the prevention of SSI. We believe that this low certainty of evidence can be improved by conducting new studies in the future. Conclusion There is no evidence regarding which dressing is the most effective in preventing SSI in adult patients with cancer.
doi_str_mv 10.1007/s00520-022-07467-8
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Methods This systematic review was based on the Preferred Reporting Items for Systematic Reviews and Meta-Analysis , with online searches conducted in the CINHAL, Cochrane Central, LILACS, PubMed, Scopus, Embase, Livivo, and Web of Science databases. An additional search was conducted in gray literature using Google Scholar. The risk of bias was assessed using RoB 2.0. The certainty of evidence was evaluated using the Grading of Recommendations Assessment and Development and Evaluation , and the results were synthesized in a descriptive manner and using meta-analysis. Results Eleven randomized clinical trials were conducted to compare different types of dressing—silver dressing with absorbent dressing ( n  = 3), mupirocin dressing with paraffin/no dressing ( n  = 1), honey-based dressing with absorbent dressing ( n  = 1), vitamin E and silicone-containing dressing with absorbent dressing ( n  = 1), and negative pressure wound therapy with absorbent dressing ( n  = 4)—and compare the usage duration of absorbent dressing ( n  = 1). Nine trials presented a low risk of bias, and two were classified as having uncertain bias. Compared with absorbent dressing, silver dressing did not reduce the risk of developing any type of SSI in 894 clinical trial participants (risk relative RR: 0.72; 95% confidence interval [CI] [0.44, 1.17] p  = 0.18). Compared with absorbent dressing, negative pressure wound therapy did not reduce the risk of developing any type of SSI in the 1041 participants of two clinical trials (RR 0.68; 95% CI [0.31, 1.26] p  = 0.22). The certainty of evidence of the three meta-analyses was considered low or very low for the prevention of SSI. We believe that this low certainty of evidence can be improved by conducting new studies in the future. Conclusion There is no evidence regarding which dressing is the most effective in preventing SSI in adult patients with cancer.</description><identifier>ISSN: 0941-4355</identifier><identifier>EISSN: 1433-7339</identifier><identifier>DOI: 10.1007/s00520-022-07467-8</identifier><identifier>PMID: 36512091</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Analysis ; Cancer ; Cancer patients ; Cancer surgery ; Clinical trials ; Database searching ; Disease prevention ; Health aspects ; Infection ; Infection control ; Internet/Web search services ; Medical dressings ; Medicine ; Medicine &amp; Public Health ; Meta-analysis ; Mupirocin ; Nursing ; Nursing Research ; Oncology ; Online databases ; Online searching ; Pain Medicine ; Prevention ; Rehabilitation Medicine ; Review ; Surgery ; Surgical site infections ; Systematic review ; Wound healing</subject><ispartof>Supportive care in cancer, 2023-01, Vol.31 (1), p.11-11, Article 11</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>COPYRIGHT 2023 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-78ec502a18a23a7e2e61b0c431f54ccedb5ce14e6e2c0234f685336b7f7cf6f03</citedby><cites>FETCH-LOGICAL-c372t-78ec502a18a23a7e2e61b0c431f54ccedb5ce14e6e2c0234f685336b7f7cf6f03</cites><orcidid>0000-0002-7601-3399 ; 0000-0002-1939-6194 ; 0000-0002-2883-3640 ; 0000-0002-1006-9357 ; 0000-0002-9363-0057 ; 0000-0002-9782-3366</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00520-022-07467-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00520-022-07467-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27911,27912,41475,42544,51306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36512091$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dias, Thais Almeida</creatorcontrib><creatorcontrib>Fernandes, Daiane Rubinato</creatorcontrib><creatorcontrib>dos Santos, Bruna Nogueira</creatorcontrib><creatorcontrib>dos Reis, Paula Elaine Diniz</creatorcontrib><creatorcontrib>Margatho, Amanda Salles</creatorcontrib><creatorcontrib>Silveira, Renata Cristina de Campos Pereira</creatorcontrib><title>Dressing to prevent surgical site infection in adult patients with cancer: a systematic review with meta-analysis</title><title>Supportive care in cancer</title><addtitle>Support Care Cancer</addtitle><addtitle>Support Care Cancer</addtitle><description>  Purpose To identify the most effective dressing for application to surgical wounds with primary closure to prevent surgical site infection (SSI) in adult patients with cancer undergoing elective surgeries. Methods This systematic review was based on the Preferred Reporting Items for Systematic Reviews and Meta-Analysis , with online searches conducted in the CINHAL, Cochrane Central, LILACS, PubMed, Scopus, Embase, Livivo, and Web of Science databases. An additional search was conducted in gray literature using Google Scholar. The risk of bias was assessed using RoB 2.0. The certainty of evidence was evaluated using the Grading of Recommendations Assessment and Development and Evaluation , and the results were synthesized in a descriptive manner and using meta-analysis. Results Eleven randomized clinical trials were conducted to compare different types of dressing—silver dressing with absorbent dressing ( n  = 3), mupirocin dressing with paraffin/no dressing ( n  = 1), honey-based dressing with absorbent dressing ( n  = 1), vitamin E and silicone-containing dressing with absorbent dressing ( n  = 1), and negative pressure wound therapy with absorbent dressing ( n  = 4)—and compare the usage duration of absorbent dressing ( n  = 1). Nine trials presented a low risk of bias, and two were classified as having uncertain bias. Compared with absorbent dressing, silver dressing did not reduce the risk of developing any type of SSI in 894 clinical trial participants (risk relative RR: 0.72; 95% confidence interval [CI] [0.44, 1.17] p  = 0.18). Compared with absorbent dressing, negative pressure wound therapy did not reduce the risk of developing any type of SSI in the 1041 participants of two clinical trials (RR 0.68; 95% CI [0.31, 1.26] p  = 0.22). The certainty of evidence of the three meta-analyses was considered low or very low for the prevention of SSI. We believe that this low certainty of evidence can be improved by conducting new studies in the future. Conclusion There is no evidence regarding which dressing is the most effective in preventing SSI in adult patients with cancer.</description><subject>Analysis</subject><subject>Cancer</subject><subject>Cancer patients</subject><subject>Cancer surgery</subject><subject>Clinical trials</subject><subject>Database searching</subject><subject>Disease prevention</subject><subject>Health aspects</subject><subject>Infection</subject><subject>Infection control</subject><subject>Internet/Web search services</subject><subject>Medical dressings</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Meta-analysis</subject><subject>Mupirocin</subject><subject>Nursing</subject><subject>Nursing Research</subject><subject>Oncology</subject><subject>Online databases</subject><subject>Online searching</subject><subject>Pain Medicine</subject><subject>Prevention</subject><subject>Rehabilitation Medicine</subject><subject>Review</subject><subject>Surgery</subject><subject>Surgical site infections</subject><subject>Systematic review</subject><subject>Wound healing</subject><issn>0941-4355</issn><issn>1433-7339</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kc1rFTEUxYNY7LP6D7iQgBs30958TWbclapVKLjRdcjLu_NMmY_X3EzL--9NO7VFKSWLhNzfOZzkMPZOwLEAsCcEYCRUIGUFVte2al6wldBKVVap9iVbQatFpZUxh-w10SWAsNbIV-xQ1UZIaMWKXX1OSBTHLc8T3yW8xjFzmtM2Bt9zihl5HDsMOU5jOXG_mfvMdz7HAhK_ifk3D34MmD5xz2lPGYcyDLxYRbxZgAGzr_zo-z1FesMOOt8Tvr3fj9ivr19-nn2rLn6cfz87vaiCsjJXtsFgQHrReKm8RYm1WEPQSnRGh4CbtQkoNNYoA0ilu7oxStVr29nQ1R2oI_Zx8d2l6WpGym6IFLDv_YjTTE5ao0HXtZUF_fAfejnNqeS9o1TTgtbikdr6Hl35lSknH25N3alVAFByt4U6foIqa4NDDNOIXSz3_wjkIghpIkrYuV2Kg097J8Dd9uyWnl3p2d317Joien-feF4PuHmQ_C22AGoBqIzGLabHJz1j-wcohbJ5</recordid><startdate>20230101</startdate><enddate>20230101</enddate><creator>Dias, Thais Almeida</creator><creator>Fernandes, Daiane Rubinato</creator><creator>dos Santos, Bruna Nogueira</creator><creator>dos Reis, Paula Elaine Diniz</creator><creator>Margatho, Amanda Salles</creator><creator>Silveira, Renata Cristina de Campos Pereira</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88J</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HEHIP</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2R</scope><scope>M2S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7601-3399</orcidid><orcidid>https://orcid.org/0000-0002-1939-6194</orcidid><orcidid>https://orcid.org/0000-0002-2883-3640</orcidid><orcidid>https://orcid.org/0000-0002-1006-9357</orcidid><orcidid>https://orcid.org/0000-0002-9363-0057</orcidid><orcidid>https://orcid.org/0000-0002-9782-3366</orcidid></search><sort><creationdate>20230101</creationdate><title>Dressing to prevent surgical site infection in adult patients with cancer: a systematic review with meta-analysis</title><author>Dias, Thais Almeida ; 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Methods This systematic review was based on the Preferred Reporting Items for Systematic Reviews and Meta-Analysis , with online searches conducted in the CINHAL, Cochrane Central, LILACS, PubMed, Scopus, Embase, Livivo, and Web of Science databases. An additional search was conducted in gray literature using Google Scholar. The risk of bias was assessed using RoB 2.0. The certainty of evidence was evaluated using the Grading of Recommendations Assessment and Development and Evaluation , and the results were synthesized in a descriptive manner and using meta-analysis. Results Eleven randomized clinical trials were conducted to compare different types of dressing—silver dressing with absorbent dressing ( n  = 3), mupirocin dressing with paraffin/no dressing ( n  = 1), honey-based dressing with absorbent dressing ( n  = 1), vitamin E and silicone-containing dressing with absorbent dressing ( n  = 1), and negative pressure wound therapy with absorbent dressing ( n  = 4)—and compare the usage duration of absorbent dressing ( n  = 1). Nine trials presented a low risk of bias, and two were classified as having uncertain bias. Compared with absorbent dressing, silver dressing did not reduce the risk of developing any type of SSI in 894 clinical trial participants (risk relative RR: 0.72; 95% confidence interval [CI] [0.44, 1.17] p  = 0.18). Compared with absorbent dressing, negative pressure wound therapy did not reduce the risk of developing any type of SSI in the 1041 participants of two clinical trials (RR 0.68; 95% CI [0.31, 1.26] p  = 0.22). The certainty of evidence of the three meta-analyses was considered low or very low for the prevention of SSI. We believe that this low certainty of evidence can be improved by conducting new studies in the future. Conclusion There is no evidence regarding which dressing is the most effective in preventing SSI in adult patients with cancer.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>36512091</pmid><doi>10.1007/s00520-022-07467-8</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-7601-3399</orcidid><orcidid>https://orcid.org/0000-0002-1939-6194</orcidid><orcidid>https://orcid.org/0000-0002-2883-3640</orcidid><orcidid>https://orcid.org/0000-0002-1006-9357</orcidid><orcidid>https://orcid.org/0000-0002-9363-0057</orcidid><orcidid>https://orcid.org/0000-0002-9782-3366</orcidid></addata></record>
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subjects Analysis
Cancer
Cancer patients
Cancer surgery
Clinical trials
Database searching
Disease prevention
Health aspects
Infection
Infection control
Internet/Web search services
Medical dressings
Medicine
Medicine & Public Health
Meta-analysis
Mupirocin
Nursing
Nursing Research
Oncology
Online databases
Online searching
Pain Medicine
Prevention
Rehabilitation Medicine
Review
Surgery
Surgical site infections
Systematic review
Wound healing
title Dressing to prevent surgical site infection in adult patients with cancer: a systematic review with meta-analysis
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