Collagen membrane from bovine pericardium for treatment of long bone defect
First published: 17 August 2022 The treatment of bone regeneration failures has been constantly improved with the study of new biomaterials. Techgraft® is a collagen membrane derived from bovine pericardium, which has been shown to have biocompatibility and effectiveness in tissue repair. However, i...
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| Veröffentlicht in: | Journal of biomedical materials research. Part B, Applied biomaterials Applied biomaterials, 2023-02, Vol.111 (2), p.261-270 |
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| container_title | Journal of biomedical materials research. Part B, Applied biomaterials |
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| creator | Yamanaka, J. S. Oliveira, A. C. Bastos, Ana Raquel Fernandes Fernandes, Emanuel Mouta Reis, R. L. Correlo, V. M. Shimano, A. C. |
| description | First published: 17 August 2022
The treatment of bone regeneration failures has been constantly improved with the study of new biomaterials. Techgraft® is a collagen membrane derived from bovine pericardium, which has been shown to have biocompatibility and effectiveness in tissue repair. However, its use in orthopedics has not yet been evaluated. Therefore, the purpose of this study was to characterize a bovine pericardium collagen membrane and evaluate the effects of its use in the regeneration of a bone defect in rat tibia. Scanning electron microscopy, atomic force microscopy, weight lost and water uptake tests, and mechanical test were performed. Afterwards, the membrane was tested in an experimental study, using 12 male Sprague Dawley rats. A bone defect was surgically made in tibiae of animals, which were assigned to two groups (n = 6): bone defect treated with collagen membrane (TG) and bone defect without treatment (CONT). Then, tibiae were submitted to micro-CT. The membranes preserved their natural collagen characteristics, presenting great strength, high water absorption, hydrophilicity, and almost complete dissolution in 30 days. In the experimental study, the membrane enhanced the growth of bone tissue in contact with its surface. A higher bone volume and trabeculae number and less trabecular space was observed in bone defects of the membrane group compared to the control group at 21 days. In conclusion, the Techgraft membrane seems to have favorable characteristics for treatment of long bone repair.
The authors gratefully acknowledge the financial support from the São Paulo Research Foundation (reference 2017/20051-0) and the scholarship from the Coordination for the Improvement of Higher Education Personnel. |
| doi_str_mv | 10.1002/jbm.b.35148 |
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The treatment of bone regeneration failures has been constantly improved with the study of new biomaterials. Techgraft® is a collagen membrane derived from bovine pericardium, which has been shown to have biocompatibility and effectiveness in tissue repair. However, its use in orthopedics has not yet been evaluated. Therefore, the purpose of this study was to characterize a bovine pericardium collagen membrane and evaluate the effects of its use in the regeneration of a bone defect in rat tibia. Scanning electron microscopy, atomic force microscopy, weight lost and water uptake tests, and mechanical test were performed. Afterwards, the membrane was tested in an experimental study, using 12 male Sprague Dawley rats. A bone defect was surgically made in tibiae of animals, which were assigned to two groups (n = 6): bone defect treated with collagen membrane (TG) and bone defect without treatment (CONT). Then, tibiae were submitted to micro-CT. The membranes preserved their natural collagen characteristics, presenting great strength, high water absorption, hydrophilicity, and almost complete dissolution in 30 days. In the experimental study, the membrane enhanced the growth of bone tissue in contact with its surface. A higher bone volume and trabeculae number and less trabecular space was observed in bone defects of the membrane group compared to the control group at 21 days. In conclusion, the Techgraft membrane seems to have favorable characteristics for treatment of long bone repair.
The authors gratefully acknowledge the financial support from the São Paulo Research Foundation (reference 2017/20051-0) and the scholarship from the Coordination for the Improvement of Higher Education Personnel.</description><identifier>ISSN: 1552-4973</identifier><identifier>EISSN: 1552-4981</identifier><identifier>DOI: 10.1002/jbm.b.35148</identifier><identifier>PMID: 36507698</identifier><language>eng</language><publisher>Hoboken, USA: Wiley</publisher><subject>Animals ; Atomic force microscopy ; Atomic properties ; Biocompatibility ; Biocompatible Materials ; biomaterial ; Biomaterials ; Biomedical materials ; Bone growth ; Bone healing ; Bone Regeneration ; Bone repair ; Cattle ; Collagen ; Collagen - pharmacology ; Defects ; Long bone ; Male ; Materials research ; Materials science ; Mechanical tests ; Membranes ; Membranes, Artificial ; Microscopy ; Orthopedics ; Pericardium ; Rats ; Rats, Sprague-Dawley ; Regeneration ; Regeneration (physiology) ; Scanning electron microscopy ; Science & Technology ; Tibia ; Water ; Water absorption ; Water uptake</subject><ispartof>Journal of biomedical materials research. Part B, Applied biomaterials, 2023-02, Vol.111 (2), p.261-270</ispartof><rights>2022 Wiley Periodicals LLC.</rights><rights>2023 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4228-172b669b6595e6a32266b2caa6f566556ef59509f3d3ab426ca9ba3dd000ac333</citedby><cites>FETCH-LOGICAL-c4228-172b669b6595e6a32266b2caa6f566556ef59509f3d3ab426ca9ba3dd000ac333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjbm.b.35148$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjbm.b.35148$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36507698$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamanaka, J. S.</creatorcontrib><creatorcontrib>Oliveira, A. C.</creatorcontrib><creatorcontrib>Bastos, Ana Raquel Fernandes</creatorcontrib><creatorcontrib>Fernandes, Emanuel Mouta</creatorcontrib><creatorcontrib>Reis, R. L.</creatorcontrib><creatorcontrib>Correlo, V. M.</creatorcontrib><creatorcontrib>Shimano, A. C.</creatorcontrib><title>Collagen membrane from bovine pericardium for treatment of long bone defect</title><title>Journal of biomedical materials research. Part B, Applied biomaterials</title><addtitle>J Biomed Mater Res B Appl Biomater</addtitle><description>First published: 17 August 2022
The treatment of bone regeneration failures has been constantly improved with the study of new biomaterials. Techgraft® is a collagen membrane derived from bovine pericardium, which has been shown to have biocompatibility and effectiveness in tissue repair. However, its use in orthopedics has not yet been evaluated. Therefore, the purpose of this study was to characterize a bovine pericardium collagen membrane and evaluate the effects of its use in the regeneration of a bone defect in rat tibia. Scanning electron microscopy, atomic force microscopy, weight lost and water uptake tests, and mechanical test were performed. Afterwards, the membrane was tested in an experimental study, using 12 male Sprague Dawley rats. A bone defect was surgically made in tibiae of animals, which were assigned to two groups (n = 6): bone defect treated with collagen membrane (TG) and bone defect without treatment (CONT). Then, tibiae were submitted to micro-CT. The membranes preserved their natural collagen characteristics, presenting great strength, high water absorption, hydrophilicity, and almost complete dissolution in 30 days. In the experimental study, the membrane enhanced the growth of bone tissue in contact with its surface. A higher bone volume and trabeculae number and less trabecular space was observed in bone defects of the membrane group compared to the control group at 21 days. In conclusion, the Techgraft membrane seems to have favorable characteristics for treatment of long bone repair.
The authors gratefully acknowledge the financial support from the São Paulo Research Foundation (reference 2017/20051-0) and the scholarship from the Coordination for the Improvement of Higher Education Personnel.</description><subject>Animals</subject><subject>Atomic force microscopy</subject><subject>Atomic properties</subject><subject>Biocompatibility</subject><subject>Biocompatible Materials</subject><subject>biomaterial</subject><subject>Biomaterials</subject><subject>Biomedical materials</subject><subject>Bone growth</subject><subject>Bone healing</subject><subject>Bone Regeneration</subject><subject>Bone repair</subject><subject>Cattle</subject><subject>Collagen</subject><subject>Collagen - pharmacology</subject><subject>Defects</subject><subject>Long bone</subject><subject>Male</subject><subject>Materials research</subject><subject>Materials science</subject><subject>Mechanical tests</subject><subject>Membranes</subject><subject>Membranes, Artificial</subject><subject>Microscopy</subject><subject>Orthopedics</subject><subject>Pericardium</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Regeneration</subject><subject>Regeneration (physiology)</subject><subject>Scanning electron microscopy</subject><subject>Science & Technology</subject><subject>Tibia</subject><subject>Water</subject><subject>Water absorption</subject><subject>Water uptake</subject><issn>1552-4973</issn><issn>1552-4981</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90DtPwzAUBWALgXgUJnYUiQUJtfgR3yYjrXiDWGC27OQapYrjYieg_nsMBQYGJl_Jn498DyGHjE4YpfxsYdzETIRkebFBdpmUfJyXBdv8nadih-zFuEgYqBTbZEeApFMoi11yN_dtq1-wyxw6E3SHmQ3eZca_NWleYmgqHepmcJn1IesD6t5h12feZq3vXhJMrEaLVb9PtqxuIx58nyPyfHnxNL8e3z9e3czP78dVznkxZlNuAEoDspQIWnAOYHilNVgJICWgTTe0tKIW2uQcKl0aLeqaUqorIcSInKxzl8G_Dhh75ZpYYdqjQz9ExadSABQ0h0SP_9CFH0KXfvelmIQCaFKna1UFH2NAq5ahcTqsFKPqs2OVOlZGfXWc9NF35mAc1r_2p9QE-Bq8Ny2u_stSt7OH2U9qtn4UUhNLFfCtib2OihWcqyJ1BuID_CGQRA</recordid><startdate>202302</startdate><enddate>202302</enddate><creator>Yamanaka, J. 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Part B, Applied biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamanaka, J. S.</au><au>Oliveira, A. C.</au><au>Bastos, Ana Raquel Fernandes</au><au>Fernandes, Emanuel Mouta</au><au>Reis, R. L.</au><au>Correlo, V. M.</au><au>Shimano, A. C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Collagen membrane from bovine pericardium for treatment of long bone defect</atitle><jtitle>Journal of biomedical materials research. Part B, Applied biomaterials</jtitle><addtitle>J Biomed Mater Res B Appl Biomater</addtitle><date>2023-02</date><risdate>2023</risdate><volume>111</volume><issue>2</issue><spage>261</spage><epage>270</epage><pages>261-270</pages><issn>1552-4973</issn><eissn>1552-4981</eissn><abstract>First published: 17 August 2022
The treatment of bone regeneration failures has been constantly improved with the study of new biomaterials. Techgraft® is a collagen membrane derived from bovine pericardium, which has been shown to have biocompatibility and effectiveness in tissue repair. However, its use in orthopedics has not yet been evaluated. Therefore, the purpose of this study was to characterize a bovine pericardium collagen membrane and evaluate the effects of its use in the regeneration of a bone defect in rat tibia. Scanning electron microscopy, atomic force microscopy, weight lost and water uptake tests, and mechanical test were performed. Afterwards, the membrane was tested in an experimental study, using 12 male Sprague Dawley rats. A bone defect was surgically made in tibiae of animals, which were assigned to two groups (n = 6): bone defect treated with collagen membrane (TG) and bone defect without treatment (CONT). Then, tibiae were submitted to micro-CT. The membranes preserved their natural collagen characteristics, presenting great strength, high water absorption, hydrophilicity, and almost complete dissolution in 30 days. In the experimental study, the membrane enhanced the growth of bone tissue in contact with its surface. A higher bone volume and trabeculae number and less trabecular space was observed in bone defects of the membrane group compared to the control group at 21 days. In conclusion, the Techgraft membrane seems to have favorable characteristics for treatment of long bone repair.
The authors gratefully acknowledge the financial support from the São Paulo Research Foundation (reference 2017/20051-0) and the scholarship from the Coordination for the Improvement of Higher Education Personnel.</abstract><cop>Hoboken, USA</cop><pub>Wiley</pub><pmid>36507698</pmid><doi>10.1002/jbm.b.35148</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Atomic force microscopy Atomic properties Biocompatibility Biocompatible Materials biomaterial Biomaterials Biomedical materials Bone growth Bone healing Bone Regeneration Bone repair Cattle Collagen Collagen - pharmacology Defects Long bone Male Materials research Materials science Mechanical tests Membranes Membranes, Artificial Microscopy Orthopedics Pericardium Rats Rats, Sprague-Dawley Regeneration Regeneration (physiology) Scanning electron microscopy Science & Technology Tibia Water Water absorption Water uptake |
| title | Collagen membrane from bovine pericardium for treatment of long bone defect |
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