Huntington-associated protein 1 inhibition contributes to neuropathic pain by suppressing Cav1.2 activity and attenuating inflammation

Although pain dysfunction is increasingly observed in Huntington disease, the underlying mechanisms still unknown. As a crucial Huntington-associated protein, Huntington-associated protein 1 (HAP1) is enriched in normal spinal dorsal horn and dorsal root ganglia (DRG) which are regarded as "pri...

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Veröffentlicht in:	Pain (Amsterdam) 2023-06, Vol.164 (6), p.e286-e302
Hauptverfasser:	Pan, JingYing, Zhao, YaYu, Sang, Rui, Yang, RiYun, Bao, JingYin, Wu, YongJiang, Fei, Ying, Wu, Jian, Chen, Gang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain-Derived Neurotrophic Factor - metabolism Ganglia, Spinal - metabolism Hyperalgesia Mice Neuralgia - metabolism Rats Rats, Sprague-Dawley Spinal Cord Dorsal Horn - metabolism
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