18F-labeling and initial in vivo evaluation of a Hitomi peptide for imaging tissue transglutaminase 2

Tissue transglutaminase 2 (TG2) is a calcium-dependent enzyme which cross-links proteins. It is overexpressed in many diseases and plays a key role in tissue remodeling, including cell adhesion and migration. Overexpression of TG2 in breast cancer is a marker for patients at risk of recurrence. Non-...

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Veröffentlicht in:	Nuclear medicine and biology 2023-01, Vol.116-117, p.108308-108308, Article 108308
Hauptverfasser:	Ackermann, Uwe, Jäger, Luise, Rigopoulos, Angela, Burvenich, Ingrid Julienne Georgette, O'Keefe, Graeme Joseph, Scott, Andrew M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Automation Calcium Cell adhesion Cell migration Chemical synthesis Emitters Fluorine Fluorine isotopes Fluorine-18 High-performance liquid chromatography Hitomi peptide Immunohistochemistry Liquid chromatography Magnetic resonance imaging Medical imaging Metabolism N-Terminus Peptides PET imaging Positron emission Prostheses Purification Radioactive tracers Radiochemistry Radiolabelling Tissues Transglutaminase 2 Tumors Xenografts Xenotransplantation
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