Efficient identification of trait‐associated loss‐of‐function variants in the UK Biobank cohort by exome‐sequencing based genotype imputation

The large‐scale open access whole‐exome sequencing (WES) data of the UK Biobank ~200,000 participants is accelerating a new wave of genetic association studies aiming to identify rare and functional loss‐of‐function (LoF) variants associated with complex traits and diseases. We proposed to merge the...

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