Carbotrifluoromethylations of C−C Multiple Bonds (Excluding Aryl‐ and Alkynyltrifluoromethylations)

Organofluorine chemistry has become an expanding area of research in organic chemistry and drug design. The synthesis of fluorine‐containing molecules has received high significance in synthetic chemistry. Trifluoromethylative difunctionalizations of carbon‐carbon multiple bonds with the simultaneous introduction of a CF3 group and another function have considerable relevance. Because of the high importance of carbon‐carbon bond‐forming reactions in organic synthesis, carbotrifluoromethylations are considered to be a field of synthetic chemistry of increasing importance. Our current goal in this review is to summarize recent developments of various trifluoromethylation reactions (excluding aryl‐ and alkynyl‐trifluoromethylations) taking into consideration several main approaches, such as alkenyltrifluoromethylation, alkyltrifluoromethylation, carbonyltrifluoromethylation, and cyanotrifluoromethylation reactions. One main method for the access of organofluorine compounds is the trifluoromethylative functionalization of an olefin bond, which simultaneously introduces a functional group and a trifluoromethyl element into an olefin framework. This review provides a concise overview of this powerful and versatile method.