The interaction between obesity and visceral hypersensitivity
Obesity has been a worldwide problem associated with numerous chronic diseases such as cardiovascular disease, type 2 diabetes, and metabolic disorders. It may also play a role in visceral hypersensitivity, contributing to irritable bowel syndrome. (i) Adipose tissue secretes various inflammatory me...
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| Veröffentlicht in: | Journal of gastroenterology and hepatology 2023-03, Vol.38 (3), p.370-377 |
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| container_end_page | 377 |
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| container_issue | 3 |
| container_start_page | 370 |
| container_title | Journal of gastroenterology and hepatology |
| container_volume | 38 |
| creator | Yanping, Wu Gao, Xuefen Cheng, Yizun Liu, Mi Liao, Siyu Zhou, Jing Hao, Jiaming Jiang, Gemeng Lu, Yixuan Qu, Tianyao Qin, Bin Cheng, Yan |
| description | Obesity has been a worldwide problem associated with numerous chronic diseases such as cardiovascular disease, type 2 diabetes, and metabolic disorders. It may also play a role in visceral hypersensitivity, contributing to irritable bowel syndrome. (i) Adipose tissue secretes various inflammatory mediators, causing intestinal hyperpermeability and nerve endings activation. (ii) Obesity and gastrointestinal microbiota could affect each other, and microbial metabolites can increase sensitivity of the colon. (iii) Vitamin D deficiency contributes to both fat accumulation and disruption of the intestinal mucosal barrier. (iv) Brain‐gut axis may be another bridge from obesity to visceral hypersensitivity. |
| doi_str_mv | 10.1111/jgh.16083 |
| format | Article |
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It may also play a role in visceral hypersensitivity, contributing to irritable bowel syndrome. (i) Adipose tissue secretes various inflammatory mediators, causing intestinal hyperpermeability and nerve endings activation. (ii) Obesity and gastrointestinal microbiota could affect each other, and microbial metabolites can increase sensitivity of the colon. (iii) Vitamin D deficiency contributes to both fat accumulation and disruption of the intestinal mucosal barrier. 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(iv) Brain‐gut axis may be another bridge from obesity to visceral hypersensitivity.</description><subject>Adipose tissue</subject><subject>Cardiovascular diseases</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Humans</subject><subject>Hypersensitivity</subject><subject>Inflammation</subject><subject>Intestinal Mucosa - metabolism</subject><subject>Intestine</subject><subject>Intestines</subject><subject>Irritable bowel syndrome</subject><subject>Irritable Bowel Syndrome - metabolism</subject><subject>Metabolic disorders</subject><subject>Microbiota</subject><subject>Nerve endings</subject><subject>Obesity</subject><subject>Vitamin D</subject><subject>Vitamin deficiency</subject><issn>0815-9319</issn><issn>1440-1746</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10LFOwzAQBmALgWgpDLwAisQCQ1rbZzvJwIAqaEGVWMpspc6FpkqTYiet8va4tDAgccsN9-nX6SfkmtEh8zNafSyHTNEYTkifCUFDFgl1Svo0ZjJMgCU9cuHcilIqaCTPSQ-UiGIeqz55mC8xKKoGbWqaoq6CBTY7xCqoF-iKpgvSKgu2hTMelMGy26B1WPlLsfXXS3KWp6XDq-MekPfnp_l4Gs7eJi_jx1loQAKEADxXIJIskpAq5CCQZjxVGQNmMqDCRIZFGQppgDMKMecgeZILoagUOYMBuTvkbmz92aJr9Hr_UlmmFdat09wHA01ivqe3f-iqbm3lv_MqlixhQMGr-4MytnbOYq43tlinttOM6n2n2neqvzv19uaY2C7WmP3KnxI9GB3Ariix-z9Jv06mh8gv0SV97w</recordid><startdate>202303</startdate><enddate>202303</enddate><creator>Yanping, Wu</creator><creator>Gao, Xuefen</creator><creator>Cheng, Yizun</creator><creator>Liu, Mi</creator><creator>Liao, Siyu</creator><creator>Zhou, Jing</creator><creator>Hao, Jiaming</creator><creator>Jiang, Gemeng</creator><creator>Lu, Yixuan</creator><creator>Qu, Tianyao</creator><creator>Qin, Bin</creator><creator>Cheng, Yan</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4687-4374</orcidid><orcidid>https://orcid.org/0000-0002-9795-3726</orcidid><orcidid>https://orcid.org/0000-0002-6781-7096</orcidid></search><sort><creationdate>202303</creationdate><title>The interaction between obesity and visceral hypersensitivity</title><author>Yanping, Wu ; Gao, Xuefen ; Cheng, Yizun ; Liu, Mi ; Liao, Siyu ; Zhou, Jing ; Hao, Jiaming ; Jiang, Gemeng ; Lu, Yixuan ; Qu, Tianyao ; Qin, Bin ; Cheng, Yan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3533-332f6349d753a6e234e0d2a6d131cd304c7c17de45c321038223529f446054f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adipose tissue</topic><topic>Cardiovascular diseases</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Humans</topic><topic>Hypersensitivity</topic><topic>Inflammation</topic><topic>Intestinal Mucosa - metabolism</topic><topic>Intestine</topic><topic>Intestines</topic><topic>Irritable bowel syndrome</topic><topic>Irritable Bowel Syndrome - metabolism</topic><topic>Metabolic disorders</topic><topic>Microbiota</topic><topic>Nerve endings</topic><topic>Obesity</topic><topic>Vitamin D</topic><topic>Vitamin deficiency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yanping, Wu</creatorcontrib><creatorcontrib>Gao, Xuefen</creatorcontrib><creatorcontrib>Cheng, Yizun</creatorcontrib><creatorcontrib>Liu, Mi</creatorcontrib><creatorcontrib>Liao, Siyu</creatorcontrib><creatorcontrib>Zhou, Jing</creatorcontrib><creatorcontrib>Hao, Jiaming</creatorcontrib><creatorcontrib>Jiang, Gemeng</creatorcontrib><creatorcontrib>Lu, Yixuan</creatorcontrib><creatorcontrib>Qu, Tianyao</creatorcontrib><creatorcontrib>Qin, Bin</creatorcontrib><creatorcontrib>Cheng, Yan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastroenterology and hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yanping, Wu</au><au>Gao, Xuefen</au><au>Cheng, Yizun</au><au>Liu, Mi</au><au>Liao, Siyu</au><au>Zhou, Jing</au><au>Hao, Jiaming</au><au>Jiang, Gemeng</au><au>Lu, Yixuan</au><au>Qu, Tianyao</au><au>Qin, Bin</au><au>Cheng, Yan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The interaction between obesity and visceral hypersensitivity</atitle><jtitle>Journal of gastroenterology and hepatology</jtitle><addtitle>J Gastroenterol Hepatol</addtitle><date>2023-03</date><risdate>2023</risdate><volume>38</volume><issue>3</issue><spage>370</spage><epage>377</epage><pages>370-377</pages><issn>0815-9319</issn><eissn>1440-1746</eissn><abstract>Obesity has been a worldwide problem associated with numerous chronic diseases such as cardiovascular disease, type 2 diabetes, and metabolic disorders. 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| ispartof | Journal of gastroenterology and hepatology, 2023-03, Vol.38 (3), p.370-377 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adipose tissue Cardiovascular diseases Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - metabolism Humans Hypersensitivity Inflammation Intestinal Mucosa - metabolism Intestine Intestines Irritable bowel syndrome Irritable Bowel Syndrome - metabolism Metabolic disorders Microbiota Nerve endings Obesity Vitamin D Vitamin deficiency |
| title | The interaction between obesity and visceral hypersensitivity |
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