Histone-deacetylase-inhibitory effects of periodontopathic-bacterial metabolites induce human gingival epithelial Ca9-22 cell death

[Abstract] Dental plaque bacteria produce high concentrations of short-chain fatty acids (SCFAs), as bacterial metabolites. SCFA-treated gingival epithelial cells undergo cell death. Our previous reports demonstrated that butyrate-induced cell death depends on autophagy and reactive oxygen species (...

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Veröffentlicht in:	Odontology 2023-07, Vol.111 (3), p.658-667
Hauptverfasser:	Uemichi, Kazuki, Mikami, Yoshikazu, Watanabe, Takayasu, Shinozuka, Keiji, Tonogi, Morio, Tsuda, Hiromasa
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Antigens, Neoplasm - pharmacology Apoptosis Autophagy Bacteria Butyrates - metabolism Butyrates - pharmacology Carbonic Anhydrase IX - metabolism Carbonic Anhydrase IX - pharmacology Cell Death Dental plaque Dentistry Epithelial cells Epithelial Cells - metabolism Fatty acids Gingiva Histone acetyltransferase Histone deacetylase Histone Deacetylase Inhibitors - pharmacology Histone Deacetylases - metabolism Histone Deacetylases - pharmacology Histone H3 Histones - metabolism Histones - pharmacology Humans Medicine Metabolites Oral and Maxillofacial Surgery Original Article Propionates - pharmacology Propionic acid Reactive oxygen species Reactive Oxygen Species - metabolism Reactive Oxygen Species - pharmacology Sequence analysis Transcriptomes Western blotting
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