Organoid modeling of human fetal lung alveolar development reveals mechanisms of cell fate patterning and neonatal respiratory disease

Variation in lung alveolar development is strongly linked to disease susceptibility. However, underlying cellular and molecular mechanisms are difficult to study in humans. We have identified an alveolar-fated epithelial progenitor in human fetal lungs, which we grow as self-organizing organoids tha...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell stem cell 2023-01, Vol.30 (1), p.20-37.e9
Hauptverfasser:	Lim, Kyungtae, Donovan, Alex P.A., Tang, Walfred, Sun, Dawei, He, Peng, Pett, J. Patrick, Teichmann, Sarah A., Marioni, John C., Meyer, Kerstin B., Brand, Andrea H., Rawlins, Emma L.
Format:	Artikel
Sprache:	eng
Schlagworte:	alveolar differentiation Alveolar Epithelial Cells - metabolism alveolar patterning Cell Differentiation - physiology Cell Lineage distal tip human lung development Humans Infant, Newborn Lung - embryology NKX2.1 NOTUM Organoids Respiratory Tract Diseases - embryology Respiratory Tract Diseases - metabolism stem cell WNT
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!