Inner mitochondrial membrane structure and fusion dynamics are altered in senescent human iPSC-derived and primary rat cardiomyocytes

Dysfunction of the aging heart is a major cause of death in the human population. Amongst other tasks, mitochondria are pivotal to supply the working heart with ATP. The mitochondrial inner membrane (IMM) ultrastructure is tailored to meet these demands and to provide nano-compartments for specific...

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Veröffentlicht in:	Biochimica et biophysica acta. Bioenergetics 2023-04, Vol.1864 (2), p.148949-148949, Article 148949
Hauptverfasser:	Morris, Silke, Molina-Riquelme, Isidora, Barrientos, Gonzalo, Bravo, Francisco, Aedo, Geraldine, Gómez, Wileidy, Lagos, Daniel, Verdejo, Hugo, Peischard, Stefan, Seebohm, Guiscard, Psathaki, Olympia Ekaterini, Eisner, Verónica, Busch, Karin B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animals Cardiomyocytes Cristae structure Doxorubicin Doxorubicin - metabolism Doxorubicin - pharmacology Humans Induced Pluripotent Stem Cells - metabolism Inner mitochondrial membrane dynamics Mice Mitochondrial fusion and fission dynamics Mitochondrial Membranes - metabolism Mitochondrial Proteins - metabolism Myocytes, Cardiac - metabolism Rats Senescence
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