Synthesis, Characterization, and Application of Muscarinergic M3 Receptor Ligands Linked to Fluorescent Dyes

Through the linkage of two muscarinergic M3 receptor ligands to fluorescent tetramethylrhodamine- and cyanine-5-type dyes, two novel tool compounds, OFH5503 and OFH611, have been developed. Based on the suitable binding properties and kinetics related to the M3 subtype, both ligand-dye conjugates we...

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Veröffentlicht in:	Journal of medicinal chemistry 2022-12, Vol.65 (24), p.16494-16509
Hauptverfasser:	Köckenberger, Johannes, Fischer, Oliver, Konopa, Andreas, Bergwinkl, Sebastian, Mühlich, Susanne, Gmeiner, Peter, Kutta, Roger Jan, Hübner, Harald, Keller, Max, Heinrich, Markus R.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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