Altered neurovascular coupling in children with idiopathic generalized epilepsy
Aims Alterations in neuronal activity and cerebral hemodynamics have been reported in idiopathic generalized epilepsy (IGE) patients, possibly resulting in neurovascular decoupling; however, no neuroimaging evidence confirmed this disruption. This study aimed to investigate the possible presence of...
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| Veröffentlicht in: | CNS neuroscience & therapeutics 2023-02, Vol.29 (2), p.609-618 |
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| creator | Hu, Jie Ran, Haifeng Chen, Guiqin He, Yulun Li, Qinghui Liu, Junwei Li, Fangling Liu, Heng Zhang, Tijiang |
| description | Aims
Alterations in neuronal activity and cerebral hemodynamics have been reported in idiopathic generalized epilepsy (IGE) patients, possibly resulting in neurovascular decoupling; however, no neuroimaging evidence confirmed this disruption. This study aimed to investigate the possible presence of neurovascular decoupling and its clinical implications in childhood IGE using resting‐state fMRI and arterial spin labeling imaging.
Methods
IGE patients and healthy participants underwent resting‐state fMRI and arterial spin labeling imaging to calculate degree centrality (DC) and cerebral blood flow (CBF), respectively. Across‐voxel CBF‐DC correlations were analyzed to evaluate the neurovascular coupling within the whole gray matter, and the regional coupling of brain region was assessed with the CBF/DC ratio.
Results
The study included 26 children with IGE and 35 sex‐ and age‐matched healthy controls (HCs). Compared with the HCs, the IGE group presented lower across‐voxel CBF‐DC correlations, higher CBF/DC ratio in the right posterior cingulate cortex/precuneus, middle frontal gyrus, and medial frontal gyrus (MFG), and lower ratio in the left inferior frontal gyrus. The increased CBF/DC ratio in the right MFG was correlated with lower performance intelligence quotient scores in the IGE group.
Conclusion
Children with IGE present altered neurovascular coupling, associated with lower performance intelligence quotient scores. The study shed a new insight into the pathophysiology of epilepsy and provided potential imaging biomarkers of cognitive performances in children with IGE.
Altered neuronal activity and cerebral vascular hemodynamics have been confirmed in idiopathic generalized epilepsy (IGE) patients, thus, the coupling between neuronal activity and cerebral blood flow may be impaired, but neuroimaging evidence on neurovascular decoupling remains scarce. Here, Jie Hu et al confirmed the impairment of neurovascular coupling (NVC) in IGE children by neuroimaging. |
| doi_str_mv | 10.1111/cns.14039 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2753291107</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2768823416</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3889-80e788f4a5efe1dad79752976fcc6b19e111988297d33e74ca0aca2ae162fb33</originalsourceid><addsrcrecordid>eNp1kM9PwjAUxxujEUQP_gNmiRc9DNp1W9sjIf5KiBzkvpTuDUpKN1smwb_e6pCDie_Sl-bT73v9IHRN8JCEGinrhyTFVJygPmFZFmciFafHnuIeuvB-jXGecMHPUY_mKccpJ300G5stOCgjC62rP6RXrZEuUnXbGG2XkbaRWmlTOrDRTm9XkS513cjtSqtoCRacNPozPIdGG2j8_hKdVdJ4uDqcAzR_fJhPnuPp7OllMp7GinIuYo6BcV6lMoMKSClLJliWCJZXSuULIiB8S3AebkpKgaVKYqlkIoHkSbWgdIDuutjG1e8t-G2x0V6BMdJC3foiYRlNBCGYBfT2D7quW2fDcoHKwwyakjxQ9x2lXO29g6ponN5Ity8ILr4lF0Fy8SM5sDeHxHaxgfJI_loNwKgDdkHK_v-kYvL61kV-AUmehnI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2768823416</pqid></control><display><type>article</type><title>Altered neurovascular coupling in children with idiopathic generalized epilepsy</title><source>Wiley-Blackwell Open Access Collection</source><source>MEDLINE</source><source>Wiley Online Library</source><source>PubMed Central</source><source>Directory of Open Access Journals</source><source>EZB Electronic Journals Library</source><creator>Hu, Jie ; Ran, Haifeng ; Chen, Guiqin ; He, Yulun ; Li, Qinghui ; Liu, Junwei ; Li, Fangling ; Liu, Heng ; Zhang, Tijiang</creator><creatorcontrib>Hu, Jie ; Ran, Haifeng ; Chen, Guiqin ; He, Yulun ; Li, Qinghui ; Liu, Junwei ; Li, Fangling ; Liu, Heng ; Zhang, Tijiang</creatorcontrib><description>Aims
Alterations in neuronal activity and cerebral hemodynamics have been reported in idiopathic generalized epilepsy (IGE) patients, possibly resulting in neurovascular decoupling; however, no neuroimaging evidence confirmed this disruption. This study aimed to investigate the possible presence of neurovascular decoupling and its clinical implications in childhood IGE using resting‐state fMRI and arterial spin labeling imaging.
Methods
IGE patients and healthy participants underwent resting‐state fMRI and arterial spin labeling imaging to calculate degree centrality (DC) and cerebral blood flow (CBF), respectively. Across‐voxel CBF‐DC correlations were analyzed to evaluate the neurovascular coupling within the whole gray matter, and the regional coupling of brain region was assessed with the CBF/DC ratio.
Results
The study included 26 children with IGE and 35 sex‐ and age‐matched healthy controls (HCs). Compared with the HCs, the IGE group presented lower across‐voxel CBF‐DC correlations, higher CBF/DC ratio in the right posterior cingulate cortex/precuneus, middle frontal gyrus, and medial frontal gyrus (MFG), and lower ratio in the left inferior frontal gyrus. The increased CBF/DC ratio in the right MFG was correlated with lower performance intelligence quotient scores in the IGE group.
Conclusion
Children with IGE present altered neurovascular coupling, associated with lower performance intelligence quotient scores. The study shed a new insight into the pathophysiology of epilepsy and provided potential imaging biomarkers of cognitive performances in children with IGE.
Altered neuronal activity and cerebral vascular hemodynamics have been confirmed in idiopathic generalized epilepsy (IGE) patients, thus, the coupling between neuronal activity and cerebral blood flow may be impaired, but neuroimaging evidence on neurovascular decoupling remains scarce. Here, Jie Hu et al confirmed the impairment of neurovascular coupling (NVC) in IGE children by neuroimaging.</description><identifier>ISSN: 1755-5930</identifier><identifier>EISSN: 1755-5949</identifier><identifier>DOI: 10.1111/cns.14039</identifier><identifier>PMID: 36480481</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>Biomarkers ; Blood flow ; Brain - diagnostic imaging ; Brain mapping ; Brain research ; Cerebral blood flow ; Child ; Children ; Cognitive ability ; Convulsions & seizures ; Cortex (cingulate) ; Cortex (frontal) ; Cortex (parietal) ; Epilepsy ; Epilepsy, Generalized - diagnostic imaging ; Frontal gyrus ; Functional magnetic resonance imaging ; Hemodynamics ; Humans ; idiopathic generalized epilepsy ; Immunoglobulin E ; Intelligence ; Magnetic Resonance Imaging ; Medical imaging ; Neuroimaging ; Neuropathology ; Neuropsychology ; neurovascular coupling ; Neurovascular Coupling - physiology ; Pediatrics ; Spin labeling ; Spin Labels ; Substantia grisea</subject><ispartof>CNS neuroscience & therapeutics, 2023-02, Vol.29 (2), p.609-618</ispartof><rights>2022 The Authors. published by John Wiley & Sons Ltd.</rights><rights>2022 The Authors. CNS Neuroscience & Therapeutics published by John Wiley & Sons Ltd.</rights><rights>2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3889-80e788f4a5efe1dad79752976fcc6b19e111988297d33e74ca0aca2ae162fb33</citedby><cites>FETCH-LOGICAL-c3889-80e788f4a5efe1dad79752976fcc6b19e111988297d33e74ca0aca2ae162fb33</cites><orcidid>0000-0003-3210-5889</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fcns.14039$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fcns.14039$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,860,1411,11541,27901,27902,45550,45551,46027,46451</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36480481$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hu, Jie</creatorcontrib><creatorcontrib>Ran, Haifeng</creatorcontrib><creatorcontrib>Chen, Guiqin</creatorcontrib><creatorcontrib>He, Yulun</creatorcontrib><creatorcontrib>Li, Qinghui</creatorcontrib><creatorcontrib>Liu, Junwei</creatorcontrib><creatorcontrib>Li, Fangling</creatorcontrib><creatorcontrib>Liu, Heng</creatorcontrib><creatorcontrib>Zhang, Tijiang</creatorcontrib><title>Altered neurovascular coupling in children with idiopathic generalized epilepsy</title><title>CNS neuroscience & therapeutics</title><addtitle>CNS Neurosci Ther</addtitle><description>Aims
Alterations in neuronal activity and cerebral hemodynamics have been reported in idiopathic generalized epilepsy (IGE) patients, possibly resulting in neurovascular decoupling; however, no neuroimaging evidence confirmed this disruption. This study aimed to investigate the possible presence of neurovascular decoupling and its clinical implications in childhood IGE using resting‐state fMRI and arterial spin labeling imaging.
Methods
IGE patients and healthy participants underwent resting‐state fMRI and arterial spin labeling imaging to calculate degree centrality (DC) and cerebral blood flow (CBF), respectively. Across‐voxel CBF‐DC correlations were analyzed to evaluate the neurovascular coupling within the whole gray matter, and the regional coupling of brain region was assessed with the CBF/DC ratio.
Results
The study included 26 children with IGE and 35 sex‐ and age‐matched healthy controls (HCs). Compared with the HCs, the IGE group presented lower across‐voxel CBF‐DC correlations, higher CBF/DC ratio in the right posterior cingulate cortex/precuneus, middle frontal gyrus, and medial frontal gyrus (MFG), and lower ratio in the left inferior frontal gyrus. The increased CBF/DC ratio in the right MFG was correlated with lower performance intelligence quotient scores in the IGE group.
Conclusion
Children with IGE present altered neurovascular coupling, associated with lower performance intelligence quotient scores. The study shed a new insight into the pathophysiology of epilepsy and provided potential imaging biomarkers of cognitive performances in children with IGE.
Altered neuronal activity and cerebral vascular hemodynamics have been confirmed in idiopathic generalized epilepsy (IGE) patients, thus, the coupling between neuronal activity and cerebral blood flow may be impaired, but neuroimaging evidence on neurovascular decoupling remains scarce. Here, Jie Hu et al confirmed the impairment of neurovascular coupling (NVC) in IGE children by neuroimaging.</description><subject>Biomarkers</subject><subject>Blood flow</subject><subject>Brain - diagnostic imaging</subject><subject>Brain mapping</subject><subject>Brain research</subject><subject>Cerebral blood flow</subject><subject>Child</subject><subject>Children</subject><subject>Cognitive ability</subject><subject>Convulsions & seizures</subject><subject>Cortex (cingulate)</subject><subject>Cortex (frontal)</subject><subject>Cortex (parietal)</subject><subject>Epilepsy</subject><subject>Epilepsy, Generalized - diagnostic imaging</subject><subject>Frontal gyrus</subject><subject>Functional magnetic resonance imaging</subject><subject>Hemodynamics</subject><subject>Humans</subject><subject>idiopathic generalized epilepsy</subject><subject>Immunoglobulin E</subject><subject>Intelligence</subject><subject>Magnetic Resonance Imaging</subject><subject>Medical imaging</subject><subject>Neuroimaging</subject><subject>Neuropathology</subject><subject>Neuropsychology</subject><subject>neurovascular coupling</subject><subject>Neurovascular Coupling - physiology</subject><subject>Pediatrics</subject><subject>Spin labeling</subject><subject>Spin Labels</subject><subject>Substantia grisea</subject><issn>1755-5930</issn><issn>1755-5949</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kM9PwjAUxxujEUQP_gNmiRc9DNp1W9sjIf5KiBzkvpTuDUpKN1smwb_e6pCDie_Sl-bT73v9IHRN8JCEGinrhyTFVJygPmFZFmciFafHnuIeuvB-jXGecMHPUY_mKccpJ300G5stOCgjC62rP6RXrZEuUnXbGG2XkbaRWmlTOrDRTm9XkS513cjtSqtoCRacNPozPIdGG2j8_hKdVdJ4uDqcAzR_fJhPnuPp7OllMp7GinIuYo6BcV6lMoMKSClLJliWCJZXSuULIiB8S3AebkpKgaVKYqlkIoHkSbWgdIDuutjG1e8t-G2x0V6BMdJC3foiYRlNBCGYBfT2D7quW2fDcoHKwwyakjxQ9x2lXO29g6ponN5Ity8ILr4lF0Fy8SM5sDeHxHaxgfJI_loNwKgDdkHK_v-kYvL61kV-AUmehnI</recordid><startdate>202302</startdate><enddate>202302</enddate><creator>Hu, Jie</creator><creator>Ran, Haifeng</creator><creator>Chen, Guiqin</creator><creator>He, Yulun</creator><creator>Li, Qinghui</creator><creator>Liu, Junwei</creator><creator>Li, Fangling</creator><creator>Liu, Heng</creator><creator>Zhang, Tijiang</creator><general>John Wiley & Sons, Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3210-5889</orcidid></search><sort><creationdate>202302</creationdate><title>Altered neurovascular coupling in children with idiopathic generalized epilepsy</title><author>Hu, Jie ; Ran, Haifeng ; Chen, Guiqin ; He, Yulun ; Li, Qinghui ; Liu, Junwei ; Li, Fangling ; Liu, Heng ; Zhang, Tijiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3889-80e788f4a5efe1dad79752976fcc6b19e111988297d33e74ca0aca2ae162fb33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Biomarkers</topic><topic>Blood flow</topic><topic>Brain - diagnostic imaging</topic><topic>Brain mapping</topic><topic>Brain research</topic><topic>Cerebral blood flow</topic><topic>Child</topic><topic>Children</topic><topic>Cognitive ability</topic><topic>Convulsions & seizures</topic><topic>Cortex (cingulate)</topic><topic>Cortex (frontal)</topic><topic>Cortex (parietal)</topic><topic>Epilepsy</topic><topic>Epilepsy, Generalized - diagnostic imaging</topic><topic>Frontal gyrus</topic><topic>Functional magnetic resonance imaging</topic><topic>Hemodynamics</topic><topic>Humans</topic><topic>idiopathic generalized epilepsy</topic><topic>Immunoglobulin E</topic><topic>Intelligence</topic><topic>Magnetic Resonance Imaging</topic><topic>Medical imaging</topic><topic>Neuroimaging</topic><topic>Neuropathology</topic><topic>Neuropsychology</topic><topic>neurovascular coupling</topic><topic>Neurovascular Coupling - physiology</topic><topic>Pediatrics</topic><topic>Spin labeling</topic><topic>Spin Labels</topic><topic>Substantia grisea</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hu, Jie</creatorcontrib><creatorcontrib>Ran, Haifeng</creatorcontrib><creatorcontrib>Chen, Guiqin</creatorcontrib><creatorcontrib>He, Yulun</creatorcontrib><creatorcontrib>Li, Qinghui</creatorcontrib><creatorcontrib>Liu, Junwei</creatorcontrib><creatorcontrib>Li, Fangling</creatorcontrib><creatorcontrib>Liu, Heng</creatorcontrib><creatorcontrib>Zhang, Tijiang</creatorcontrib><collection>Wiley-Blackwell Open Access Collection</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>CNS neuroscience & therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hu, Jie</au><au>Ran, Haifeng</au><au>Chen, Guiqin</au><au>He, Yulun</au><au>Li, Qinghui</au><au>Liu, Junwei</au><au>Li, Fangling</au><au>Liu, Heng</au><au>Zhang, Tijiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Altered neurovascular coupling in children with idiopathic generalized epilepsy</atitle><jtitle>CNS neuroscience & therapeutics</jtitle><addtitle>CNS Neurosci Ther</addtitle><date>2023-02</date><risdate>2023</risdate><volume>29</volume><issue>2</issue><spage>609</spage><epage>618</epage><pages>609-618</pages><issn>1755-5930</issn><eissn>1755-5949</eissn><abstract>Aims
Alterations in neuronal activity and cerebral hemodynamics have been reported in idiopathic generalized epilepsy (IGE) patients, possibly resulting in neurovascular decoupling; however, no neuroimaging evidence confirmed this disruption. This study aimed to investigate the possible presence of neurovascular decoupling and its clinical implications in childhood IGE using resting‐state fMRI and arterial spin labeling imaging.
Methods
IGE patients and healthy participants underwent resting‐state fMRI and arterial spin labeling imaging to calculate degree centrality (DC) and cerebral blood flow (CBF), respectively. Across‐voxel CBF‐DC correlations were analyzed to evaluate the neurovascular coupling within the whole gray matter, and the regional coupling of brain region was assessed with the CBF/DC ratio.
Results
The study included 26 children with IGE and 35 sex‐ and age‐matched healthy controls (HCs). Compared with the HCs, the IGE group presented lower across‐voxel CBF‐DC correlations, higher CBF/DC ratio in the right posterior cingulate cortex/precuneus, middle frontal gyrus, and medial frontal gyrus (MFG), and lower ratio in the left inferior frontal gyrus. The increased CBF/DC ratio in the right MFG was correlated with lower performance intelligence quotient scores in the IGE group.
Conclusion
Children with IGE present altered neurovascular coupling, associated with lower performance intelligence quotient scores. The study shed a new insight into the pathophysiology of epilepsy and provided potential imaging biomarkers of cognitive performances in children with IGE.
Altered neuronal activity and cerebral vascular hemodynamics have been confirmed in idiopathic generalized epilepsy (IGE) patients, thus, the coupling between neuronal activity and cerebral blood flow may be impaired, but neuroimaging evidence on neurovascular decoupling remains scarce. Here, Jie Hu et al confirmed the impairment of neurovascular coupling (NVC) in IGE children by neuroimaging.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>36480481</pmid><doi>10.1111/cns.14039</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-3210-5889</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Wiley-Blackwell Open Access Collection; MEDLINE; Wiley Online Library; PubMed Central; Directory of Open Access Journals; EZB Electronic Journals Library |
| subjects | Biomarkers Blood flow Brain - diagnostic imaging Brain mapping Brain research Cerebral blood flow Child Children Cognitive ability Convulsions & seizures Cortex (cingulate) Cortex (frontal) Cortex (parietal) Epilepsy Epilepsy, Generalized - diagnostic imaging Frontal gyrus Functional magnetic resonance imaging Hemodynamics Humans idiopathic generalized epilepsy Immunoglobulin E Intelligence Magnetic Resonance Imaging Medical imaging Neuroimaging Neuropathology Neuropsychology neurovascular coupling Neurovascular Coupling - physiology Pediatrics Spin labeling Spin Labels Substantia grisea |
| title | Altered neurovascular coupling in children with idiopathic generalized epilepsy |
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