First electrochemical investigation of the redox properties of DOPA–melanins by means of a carbon paste electrode
The electrochemical properties of eumelanins, a cutaneous pigment responsible for skin color, insoluble in any solvent, was studied by using a carbon paste electrode. Eumelanins synthesized by enzymatic oxidation of l-DOPA were included in the carbon paste. The concentration of melanins (10%) and th...
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| Veröffentlicht in: | Electrochimica acta 2000-01, Vol.45 (10), p.1663-1668 |
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| container_title | Electrochimica acta |
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| creator | Serpentini, Charles-Louis Gauchet, Cécile de Montauzon, Dominique Comtat, Maurice Ginestar, Jose Paillous, Nicole |
| description | The electrochemical properties of eumelanins, a cutaneous pigment responsible for skin color, insoluble in any solvent, was studied by using a carbon paste electrode. Eumelanins synthesized by enzymatic oxidation of
l-DOPA were included in the carbon paste. The concentration of melanins (10%) and the potential scan rate (10
−4 V s
−1) were chosen in ranges for which there is a linear relationship between these parameters and the current peak intensity. In these thin-layer conditions, the voltammogram of eumelanins at pH 5.6 reveals two main peaks in oxidation at +460 and +525 mV versus SCE and in reduction at +20 and −355 mV versus SCE. No variation of peak potential was observed when the pH was varied in the range 2–8. An average of two electrons (three for the first oxidation scan) were exchanged in these redox processes whereas the number of subunits in one molecule of melanin was around 15 as found by MALDI mass spectroscopy experiments. These results support the assumption of an irregular organization of monomer units in the structure of melanins. |
| doi_str_mv | 10.1016/S0013-4686(99)00388-6 |
| format | Article |
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l-DOPA were included in the carbon paste. The concentration of melanins (10%) and the potential scan rate (10
−4 V s
−1) were chosen in ranges for which there is a linear relationship between these parameters and the current peak intensity. In these thin-layer conditions, the voltammogram of eumelanins at pH 5.6 reveals two main peaks in oxidation at +460 and +525 mV versus SCE and in reduction at +20 and −355 mV versus SCE. No variation of peak potential was observed when the pH was varied in the range 2–8. An average of two electrons (three for the first oxidation scan) were exchanged in these redox processes whereas the number of subunits in one molecule of melanin was around 15 as found by MALDI mass spectroscopy experiments. These results support the assumption of an irregular organization of monomer units in the structure of melanins.</description><identifier>ISSN: 0013-4686</identifier><identifier>EISSN: 1873-3859</identifier><identifier>DOI: 10.1016/S0013-4686(99)00388-6</identifier><identifier>CODEN: ELCAAV</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Biological and medical sciences ; Electrochemistry ; Eumelanin ; Fundamental and applied biological sciences. Psychology ; Molecular biophysics ; Oxidation potential ; Physical chemistry in biology ; Reduction potential ; Synthetic polymer</subject><ispartof>Electrochimica acta, 2000-01, Vol.45 (10), p.1663-1668</ispartof><rights>2000 Elsevier Science Ltd</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c433t-f1bb1b5c3e7b90d745810dc00b9f5926f1085e54a967844638cc37669ca692023</citedby><cites>FETCH-LOGICAL-c433t-f1bb1b5c3e7b90d745810dc00b9f5926f1085e54a967844638cc37669ca692023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0013468699003886$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1251315$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Serpentini, Charles-Louis</creatorcontrib><creatorcontrib>Gauchet, Cécile</creatorcontrib><creatorcontrib>de Montauzon, Dominique</creatorcontrib><creatorcontrib>Comtat, Maurice</creatorcontrib><creatorcontrib>Ginestar, Jose</creatorcontrib><creatorcontrib>Paillous, Nicole</creatorcontrib><title>First electrochemical investigation of the redox properties of DOPA–melanins by means of a carbon paste electrode</title><title>Electrochimica acta</title><description>The electrochemical properties of eumelanins, a cutaneous pigment responsible for skin color, insoluble in any solvent, was studied by using a carbon paste electrode. Eumelanins synthesized by enzymatic oxidation of
l-DOPA were included in the carbon paste. The concentration of melanins (10%) and the potential scan rate (10
−4 V s
−1) were chosen in ranges for which there is a linear relationship between these parameters and the current peak intensity. In these thin-layer conditions, the voltammogram of eumelanins at pH 5.6 reveals two main peaks in oxidation at +460 and +525 mV versus SCE and in reduction at +20 and −355 mV versus SCE. No variation of peak potential was observed when the pH was varied in the range 2–8. An average of two electrons (three for the first oxidation scan) were exchanged in these redox processes whereas the number of subunits in one molecule of melanin was around 15 as found by MALDI mass spectroscopy experiments. These results support the assumption of an irregular organization of monomer units in the structure of melanins.</description><subject>Biological and medical sciences</subject><subject>Electrochemistry</subject><subject>Eumelanin</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Molecular biophysics</subject><subject>Oxidation potential</subject><subject>Physical chemistry in biology</subject><subject>Reduction potential</subject><subject>Synthetic polymer</subject><issn>0013-4686</issn><issn>1873-3859</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNqFkMtKJDEUhsOgMK3OIwxkIeIsSk8qldtKxBkvICjorEMqdWqM1KVNStGd7zBv6JOY7vaydBVIvj__OR8hPxnsMWBy_wqA8aKSWu4a8wuAa13Ib2TGtOIF18KskdkH8p1spHQLAEoqmJF0HGKaKHbopzj6G-yDdx0NwwOmKfxzUxgHOrZ0ukEasRkf6TyOc4xTwLS4_31xefjy_L_Hzg1hSLR-oj26YfnmqHexzvm5SxO-dzS4RdZb1yX88XZukr_Hf66PTovzi5Ozo8PzwlecT0XL6prVwnNUtYFGVUIzaDxAbVphStky0AJF5YxUuqok195zJaXxTpoSSr5Jdlb_5pHv7vM-tg_JY5dHxfE-2VKJUgumMihWoI9jShFbO4-hd_HJMrALxXap2C78WWPsUrGVObf9VuBSttZGN_iQPsOlYJyJjB2sMMzLPgSMNvmAg8cmxKzENmP4ougV_DKRkQ</recordid><startdate>20000101</startdate><enddate>20000101</enddate><creator>Serpentini, Charles-Louis</creator><creator>Gauchet, Cécile</creator><creator>de Montauzon, Dominique</creator><creator>Comtat, Maurice</creator><creator>Ginestar, Jose</creator><creator>Paillous, Nicole</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope></search><sort><creationdate>20000101</creationdate><title>First electrochemical investigation of the redox properties of DOPA–melanins by means of a carbon paste electrode</title><author>Serpentini, Charles-Louis ; Gauchet, Cécile ; de Montauzon, Dominique ; Comtat, Maurice ; Ginestar, Jose ; Paillous, Nicole</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c433t-f1bb1b5c3e7b90d745810dc00b9f5926f1085e54a967844638cc37669ca692023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Biological and medical sciences</topic><topic>Electrochemistry</topic><topic>Eumelanin</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Molecular biophysics</topic><topic>Oxidation potential</topic><topic>Physical chemistry in biology</topic><topic>Reduction potential</topic><topic>Synthetic polymer</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Serpentini, Charles-Louis</creatorcontrib><creatorcontrib>Gauchet, Cécile</creatorcontrib><creatorcontrib>de Montauzon, Dominique</creatorcontrib><creatorcontrib>Comtat, Maurice</creatorcontrib><creatorcontrib>Ginestar, Jose</creatorcontrib><creatorcontrib>Paillous, Nicole</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Electrochimica acta</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Serpentini, Charles-Louis</au><au>Gauchet, Cécile</au><au>de Montauzon, Dominique</au><au>Comtat, Maurice</au><au>Ginestar, Jose</au><au>Paillous, Nicole</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>First electrochemical investigation of the redox properties of DOPA–melanins by means of a carbon paste electrode</atitle><jtitle>Electrochimica acta</jtitle><date>2000-01-01</date><risdate>2000</risdate><volume>45</volume><issue>10</issue><spage>1663</spage><epage>1668</epage><pages>1663-1668</pages><issn>0013-4686</issn><eissn>1873-3859</eissn><coden>ELCAAV</coden><abstract>The electrochemical properties of eumelanins, a cutaneous pigment responsible for skin color, insoluble in any solvent, was studied by using a carbon paste electrode. Eumelanins synthesized by enzymatic oxidation of
l-DOPA were included in the carbon paste. The concentration of melanins (10%) and the potential scan rate (10
−4 V s
−1) were chosen in ranges for which there is a linear relationship between these parameters and the current peak intensity. In these thin-layer conditions, the voltammogram of eumelanins at pH 5.6 reveals two main peaks in oxidation at +460 and +525 mV versus SCE and in reduction at +20 and −355 mV versus SCE. No variation of peak potential was observed when the pH was varied in the range 2–8. An average of two electrons (three for the first oxidation scan) were exchanged in these redox processes whereas the number of subunits in one molecule of melanin was around 15 as found by MALDI mass spectroscopy experiments. These results support the assumption of an irregular organization of monomer units in the structure of melanins.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><doi>10.1016/S0013-4686(99)00388-6</doi><tpages>6</tpages></addata></record> |
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| subjects | Biological and medical sciences Electrochemistry Eumelanin Fundamental and applied biological sciences. Psychology Molecular biophysics Oxidation potential Physical chemistry in biology Reduction potential Synthetic polymer |
| title | First electrochemical investigation of the redox properties of DOPA–melanins by means of a carbon paste electrode |
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