Sacubitril/valsartan alleviates sepsis‐induced acute lung injury via inhibiting GSDMD‐dependent macrophage pyroptosis in mice

Sepsis‐induced acute lung injury (ALI) is a life‐threatening disorder with intricate pathogenesis. Macrophage pyroptosis reportedly plays a vital role in ALI. Although it has been established that angiotensin receptor blockers (ARBs) can reduce sepsis‐induced organ injury, the efficacy of sacubitril...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The FEBS journal 2023-04, Vol.290 (8), p.2180-2198
Hauptverfasser:	Wang, Jun, Li, Jierui, Lou, Anni, Lin, Ying, Xu, Qihan, Cui, Wanfu, Huang, Weichang, Wang, Guozhen, Li, Yang, Sun, Jing, Gong, Jiacheng, Guo, Qiuping, Qiu, Hongshen, Meng, Ying, Li, Xu
Format:	Artikel
Sprache:	eng
Schlagworte:	acute lung injury Acute Lung Injury - drug therapy Acute Lung Injury - etiology Adenosine triphosphate Angiotensin Angiotensin II Angiotensin Receptor Antagonists Angiotensin-Converting Enzyme Inhibitors Animals ATP Biochemical analysis Bone marrow Cell activation Damage prevention Inflammasomes Inflammasomes - metabolism Inflammation Inflammatory response Injury prevention Lipopolysaccharides Lungs macrophage Macrophages Macrophages - metabolism Mice Mice, Inbred C57BL NLR Family, Pyrin Domain-Containing 3 Protein - genetics Pathogenesis Pyroptosis sacubitril/valsartan Sepsis Sepsis - complications Sepsis - drug therapy Signal transduction Valsartan - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!