Lineage switch in a pediatric patient with KMT2A-MLLT3 from acute megakaryoblastic leukemia to T cell acute lymphoblastic leukemia at the fourth relapse after allo-HSCT: with literature review
We present a patient with acute megakaryoblastic leukemia (AMKL) harboring KMT2A-MLLT3 that converted to T cell acute lymphoblastic leukemia (T-ALL) at her fourth relapse. A 4-year-old girl developed AMKL with multiple swollen lymph nodes. She exhibited several recurrences in the bone marrow and die...
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| Veröffentlicht in: | International journal of hematology 2023-05, Vol.117 (5), p.781-785 |
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| creator | Gao, Li Lu, Jun Li, Jie Hu, Yixin Lu, Ye Du, Weiwei Hu, Shaoyan |
| description | We present a patient with acute megakaryoblastic leukemia (AMKL) harboring
KMT2A-MLLT3
that converted to T cell acute lymphoblastic leukemia (T-ALL) at her fourth relapse. A 4-year-old girl developed AMKL with multiple swollen lymph nodes. She exhibited several recurrences in the bone marrow and died of septic shock after her fourth relapse. Bone marrow cells at the initial diagnosis and at all four relapses had the same
KMT2A-MLLT3
fusion transcript. She also developed a somatic mutation (c.7177C > T p.Q2393X) of
NOTCH1
at the fourth relapse. This sequential phenotypic and cytogenetic study may yield valuable insights into the mechanism of AMKL to T-ALL lineage switch and possible implications for treatment selection. |
| doi_str_mv | 10.1007/s12185-022-03504-8 |
| format | Article |
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KMT2A-MLLT3
that converted to T cell acute lymphoblastic leukemia (T-ALL) at her fourth relapse. A 4-year-old girl developed AMKL with multiple swollen lymph nodes. She exhibited several recurrences in the bone marrow and died of septic shock after her fourth relapse. Bone marrow cells at the initial diagnosis and at all four relapses had the same
KMT2A-MLLT3
fusion transcript. She also developed a somatic mutation (c.7177C > T p.Q2393X) of
NOTCH1
at the fourth relapse. This sequential phenotypic and cytogenetic study may yield valuable insights into the mechanism of AMKL to T-ALL lineage switch and possible implications for treatment selection.</description><identifier>ISSN: 0925-5710</identifier><identifier>EISSN: 1865-3774</identifier><identifier>DOI: 10.1007/s12185-022-03504-8</identifier><identifier>PMID: 36472792</identifier><language>eng</language><publisher>Singapore: Springer Nature Singapore</publisher><subject>Acute lymphoblastic leukemia ; Biopsy ; Blood ; Bone marrow ; Case Report ; Chemotherapy ; Child ; Child, Preschool ; Cytogenetics ; Drug dosages ; Female ; Granulocytes ; Hematology ; Hematopoietic Stem Cell Transplantation ; Humans ; Leukemia ; Leukemia, Megakaryoblastic, Acute - genetics ; Leukemia, Megakaryoblastic, Acute - therapy ; Literature reviews ; Lymph nodes ; Lymphatic system ; Lymphocytes ; Lymphocytes T ; Medical prognosis ; Medicine ; Medicine & Public Health ; Notch1 protein ; Nuclear Proteins - genetics ; Oncology ; Patients ; Pediatrics ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - therapy ; Recurrence ; Remission (Medicine) ; Sepsis ; Septic shock ; T-Lymphocytes</subject><ispartof>International journal of hematology, 2023-05, Vol.117 (5), p.781-785</ispartof><rights>Japanese Society of Hematology 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2022. Japanese Society of Hematology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c350t-5d1af76ba0144b3aa49e87b118e801f47097ede1313b25c19461b93fd59165cf3</cites><orcidid>0000-0002-5183-2259</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12185-022-03504-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12185-022-03504-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36472792$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gao, Li</creatorcontrib><creatorcontrib>Lu, Jun</creatorcontrib><creatorcontrib>Li, Jie</creatorcontrib><creatorcontrib>Hu, Yixin</creatorcontrib><creatorcontrib>Lu, Ye</creatorcontrib><creatorcontrib>Du, Weiwei</creatorcontrib><creatorcontrib>Hu, Shaoyan</creatorcontrib><title>Lineage switch in a pediatric patient with KMT2A-MLLT3 from acute megakaryoblastic leukemia to T cell acute lymphoblastic leukemia at the fourth relapse after allo-HSCT: with literature review</title><title>International journal of hematology</title><addtitle>Int J Hematol</addtitle><addtitle>Int J Hematol</addtitle><description>We present a patient with acute megakaryoblastic leukemia (AMKL) harboring
KMT2A-MLLT3
that converted to T cell acute lymphoblastic leukemia (T-ALL) at her fourth relapse. A 4-year-old girl developed AMKL with multiple swollen lymph nodes. She exhibited several recurrences in the bone marrow and died of septic shock after her fourth relapse. Bone marrow cells at the initial diagnosis and at all four relapses had the same
KMT2A-MLLT3
fusion transcript. She also developed a somatic mutation (c.7177C > T p.Q2393X) of
NOTCH1
at the fourth relapse. This sequential phenotypic and cytogenetic study may yield valuable insights into the mechanism of AMKL to T-ALL lineage switch and possible implications for treatment selection.</description><subject>Acute lymphoblastic leukemia</subject><subject>Biopsy</subject><subject>Blood</subject><subject>Bone marrow</subject><subject>Case Report</subject><subject>Chemotherapy</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cytogenetics</subject><subject>Drug dosages</subject><subject>Female</subject><subject>Granulocytes</subject><subject>Hematology</subject><subject>Hematopoietic Stem Cell Transplantation</subject><subject>Humans</subject><subject>Leukemia</subject><subject>Leukemia, Megakaryoblastic, Acute - genetics</subject><subject>Leukemia, Megakaryoblastic, Acute - therapy</subject><subject>Literature reviews</subject><subject>Lymph nodes</subject><subject>Lymphatic system</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Notch1 protein</subject><subject>Nuclear Proteins - genetics</subject><subject>Oncology</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics</subject><subject>Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - therapy</subject><subject>Recurrence</subject><subject>Remission (Medicine)</subject><subject>Sepsis</subject><subject>Septic shock</subject><subject>T-Lymphocytes</subject><issn>0925-5710</issn><issn>1865-3774</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kc1u1DAUhS0EokPhBVggS2zYGPwTxzG7agQUkYoFYW05mZsZt84PttOqb8ej4SEDSCCxsuT73XPvPQeh54y-ZpSqN5FxVklCOSdUSFqQ6gHasKqURChVPEQbqrkkUjF6hp7EeE0pU7RQj9GZKAvFleYb9L12I9g94HjnUnfAbsQWz7BzNgXX4dkmB2PCuXjAn64afkGu6roRuA_TgG23JMAD7O2NDfdT621MucnDcgODszhNuMEdeH8i_f0wH_7FbMLpALiflpCnBPB2joBtnyBg6_1ELr9sm7frDt7lX5uWABm8dXD3FD3qrY_w7PSeo6_v3zXbS1J__vBxe1GTLluTiNwx26uytZQVRSusLTRUqmWsgoqyvlBUK9gBE0y0XHZMFyVrteh3UrNSdr04R69W3TlM3xaIyQwuHm-zI0xLNFwdLZVaVhl9-Rd6nU8b83aGV5oKoSvJMsVXqgtTjAF6Mwc3ZB8No-aYr1nzNTlf8zNfc5R-cZJe2gF2v1t-BZoBsQIxl8Y9hD-z_yP7A-klsk8</recordid><startdate>20230501</startdate><enddate>20230501</enddate><creator>Gao, Li</creator><creator>Lu, Jun</creator><creator>Li, Jie</creator><creator>Hu, Yixin</creator><creator>Lu, Ye</creator><creator>Du, Weiwei</creator><creator>Hu, Shaoyan</creator><general>Springer Nature Singapore</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5183-2259</orcidid></search><sort><creationdate>20230501</creationdate><title>Lineage switch in a pediatric patient with KMT2A-MLLT3 from acute megakaryoblastic leukemia to T cell acute lymphoblastic leukemia at the fourth relapse after allo-HSCT: with literature review</title><author>Gao, Li ; Lu, Jun ; Li, Jie ; Hu, Yixin ; Lu, Ye ; Du, Weiwei ; Hu, Shaoyan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c350t-5d1af76ba0144b3aa49e87b118e801f47097ede1313b25c19461b93fd59165cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Acute lymphoblastic leukemia</topic><topic>Biopsy</topic><topic>Blood</topic><topic>Bone marrow</topic><topic>Case Report</topic><topic>Chemotherapy</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cytogenetics</topic><topic>Drug dosages</topic><topic>Female</topic><topic>Granulocytes</topic><topic>Hematology</topic><topic>Hematopoietic Stem Cell Transplantation</topic><topic>Humans</topic><topic>Leukemia</topic><topic>Leukemia, Megakaryoblastic, Acute - genetics</topic><topic>Leukemia, Megakaryoblastic, Acute - therapy</topic><topic>Literature reviews</topic><topic>Lymph nodes</topic><topic>Lymphatic system</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Notch1 protein</topic><topic>Nuclear Proteins - genetics</topic><topic>Oncology</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics</topic><topic>Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - therapy</topic><topic>Recurrence</topic><topic>Remission (Medicine)</topic><topic>Sepsis</topic><topic>Septic shock</topic><topic>T-Lymphocytes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gao, Li</creatorcontrib><creatorcontrib>Lu, Jun</creatorcontrib><creatorcontrib>Li, Jie</creatorcontrib><creatorcontrib>Hu, Yixin</creatorcontrib><creatorcontrib>Lu, Ye</creatorcontrib><creatorcontrib>Du, Weiwei</creatorcontrib><creatorcontrib>Hu, Shaoyan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gao, Li</au><au>Lu, Jun</au><au>Li, Jie</au><au>Hu, Yixin</au><au>Lu, Ye</au><au>Du, Weiwei</au><au>Hu, Shaoyan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lineage switch in a pediatric patient with KMT2A-MLLT3 from acute megakaryoblastic leukemia to T cell acute lymphoblastic leukemia at the fourth relapse after allo-HSCT: with literature review</atitle><jtitle>International journal of hematology</jtitle><stitle>Int J Hematol</stitle><addtitle>Int J Hematol</addtitle><date>2023-05-01</date><risdate>2023</risdate><volume>117</volume><issue>5</issue><spage>781</spage><epage>785</epage><pages>781-785</pages><issn>0925-5710</issn><eissn>1865-3774</eissn><abstract>We present a patient with acute megakaryoblastic leukemia (AMKL) harboring
KMT2A-MLLT3
that converted to T cell acute lymphoblastic leukemia (T-ALL) at her fourth relapse. A 4-year-old girl developed AMKL with multiple swollen lymph nodes. She exhibited several recurrences in the bone marrow and died of septic shock after her fourth relapse. Bone marrow cells at the initial diagnosis and at all four relapses had the same
KMT2A-MLLT3
fusion transcript. She also developed a somatic mutation (c.7177C > T p.Q2393X) of
NOTCH1
at the fourth relapse. This sequential phenotypic and cytogenetic study may yield valuable insights into the mechanism of AMKL to T-ALL lineage switch and possible implications for treatment selection.</abstract><cop>Singapore</cop><pub>Springer Nature Singapore</pub><pmid>36472792</pmid><doi>10.1007/s12185-022-03504-8</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-5183-2259</orcidid></addata></record> |
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| subjects | Acute lymphoblastic leukemia Biopsy Blood Bone marrow Case Report Chemotherapy Child Child, Preschool Cytogenetics Drug dosages Female Granulocytes Hematology Hematopoietic Stem Cell Transplantation Humans Leukemia Leukemia, Megakaryoblastic, Acute - genetics Leukemia, Megakaryoblastic, Acute - therapy Literature reviews Lymph nodes Lymphatic system Lymphocytes Lymphocytes T Medical prognosis Medicine Medicine & Public Health Notch1 protein Nuclear Proteins - genetics Oncology Patients Pediatrics Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - therapy Recurrence Remission (Medicine) Sepsis Septic shock T-Lymphocytes |
| title | Lineage switch in a pediatric patient with KMT2A-MLLT3 from acute megakaryoblastic leukemia to T cell acute lymphoblastic leukemia at the fourth relapse after allo-HSCT: with literature review |
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