Lipidic extract of whole tomato reduces hyperplasia, oxidative stress and inflammation on testosterone-induced BPH in obese rats
Purpose Tomato is an important source of lycopene, a carotenoid that has been emerging as a natural preventive agent for prostate disease. Moreover, tomato contains other components with a wide range of physiological properties, but their potential beneficial effects on prostatic hyperplasia (PH) du...
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| Veröffentlicht in: | International urology and nephrology 2023-03, Vol.55 (3), p.529-539 |
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| creator | Colado-Velázquez, Juventino III Mailloux-Salinas, Patrick Arias-Chávez, David Julian Ledesma-Aparicio, Jessica Gómez-Viquez, Norma Leticia Cano-Europa, Edgard Sarabia, Gabriel Noris Bravo, Guadalupe |
| description | Purpose
Tomato is an important source of lycopene, a carotenoid that has been emerging as a natural preventive agent for prostate disease. Moreover, tomato contains other components with a wide range of physiological properties, but their potential beneficial effects on prostatic hyperplasia (PH) during obesity have not been completely established. In this study, we compared the effect of a lipidic extract of tomato saladette (STE) with
Serenoa repens
(
SR
) on obese rats with PH.
Methods
Forty-eight Wistar rats were divided in Control (C) and Obese (Ob) treated without (
n
= 12) and with (
n
= 36) testosterone enanthate (TE), once a week for 8 weeks to induce PH. After 4 weeks,
SR
and STE were administered. Biochemical parameters, oxidative stress markers and inflammatory cytokines production were determined.
Results
TE increased prostate weight and caused prostatic hyperplasia in C group, and these effects were exacerbated by obesity.
SR
and STE reverted the increase in prostate weight and hyperplasia caused by TE in C and Ob groups. Obesity increased LDL, TGs, NOx and MAD, but decreased HDLc, GSx, SOD and CAT.
SR
reverted the effects of obesity, but these were significantly reduced and HDLc increased with STE. Obesity and TE increased TNFα, IL-1β and IL-6 levels, but these were partially reverted by STE compared with
SR
.
Conclusions
Excess of fat tissue increases the alterations by PH. STE diminishes these alterations compared with
SR
, suggesting its beneficial effect to improve prostate function. Whole tomato lipid extract could serve as sole therapy or as an adjunct to pharmacological treatment for PH. |
| doi_str_mv | 10.1007/s11255-022-03383-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2747007741</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2747007741</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-593b2a8fb9b26d6b5d4e7b68f76c38fc5fda2ce9aabd168c83245b9cc8ed2a83</originalsourceid><addsrcrecordid>eNp9kctu1jAQhS1ERUvhBVggS2xYNMWx49hZQkUp0i_BonvLlwl1lcTB45R2x6Pj8peLWCCNNCP5O2dGPoS8aNlpy5h6g23LpWwY5w0TQouGPyJHrVR1kLp7_Nd8SJ4iXjPGBs3YE3Io-q7vlByOyPddXGOInsJtydYXmkb67SpNQEuabUk0Q9g8IL26WyGvk8VoT2i6jcGWeAMUSwZEapdA4zJOdq6imBZaqwCWhAVyWqCJy71NoO8-X1SQJgcINNuCz8jBaCeE5w_9mFyev788u2h2nz58PHu7a7xQsjRyEI5bPbrB8T70ToYOlOv1qHov9OjlGCz3MFjrQttrrwXvpBu81xCqThyT13vbNaevW73MzBE9TJNdIG1ouOpU_VPVtRV99Q96nba81OMqpQbFhO6GSvE95XNCzDCaNcfZ5jvTMnMfj9nHY2o85mc8hlfRywfrzc0Qfkt-5VEBsQewPi1fIP_Z_R_bH0PTnZs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2779703849</pqid></control><display><type>article</type><title>Lipidic extract of whole tomato reduces hyperplasia, oxidative stress and inflammation on testosterone-induced BPH in obese rats</title><source>Springer Nature - Complete Springer Journals</source><creator>Colado-Velázquez, Juventino III ; Mailloux-Salinas, Patrick ; Arias-Chávez, David Julian ; Ledesma-Aparicio, Jessica ; Gómez-Viquez, Norma Leticia ; Cano-Europa, Edgard ; Sarabia, Gabriel Noris ; Bravo, Guadalupe</creator><creatorcontrib>Colado-Velázquez, Juventino III ; Mailloux-Salinas, Patrick ; Arias-Chávez, David Julian ; Ledesma-Aparicio, Jessica ; Gómez-Viquez, Norma Leticia ; Cano-Europa, Edgard ; Sarabia, Gabriel Noris ; Bravo, Guadalupe</creatorcontrib><description>Purpose
Tomato is an important source of lycopene, a carotenoid that has been emerging as a natural preventive agent for prostate disease. Moreover, tomato contains other components with a wide range of physiological properties, but their potential beneficial effects on prostatic hyperplasia (PH) during obesity have not been completely established. In this study, we compared the effect of a lipidic extract of tomato saladette (STE) with
Serenoa repens
(
SR
) on obese rats with PH.
Methods
Forty-eight Wistar rats were divided in Control (C) and Obese (Ob) treated without (
n
= 12) and with (
n
= 36) testosterone enanthate (TE), once a week for 8 weeks to induce PH. After 4 weeks,
SR
and STE were administered. Biochemical parameters, oxidative stress markers and inflammatory cytokines production were determined.
Results
TE increased prostate weight and caused prostatic hyperplasia in C group, and these effects were exacerbated by obesity.
SR
and STE reverted the increase in prostate weight and hyperplasia caused by TE in C and Ob groups. Obesity increased LDL, TGs, NOx and MAD, but decreased HDLc, GSx, SOD and CAT.
SR
reverted the effects of obesity, but these were significantly reduced and HDLc increased with STE. Obesity and TE increased TNFα, IL-1β and IL-6 levels, but these were partially reverted by STE compared with
SR
.
Conclusions
Excess of fat tissue increases the alterations by PH. STE diminishes these alterations compared with
SR
, suggesting its beneficial effect to improve prostate function. Whole tomato lipid extract could serve as sole therapy or as an adjunct to pharmacological treatment for PH.</description><identifier>ISSN: 1573-2584</identifier><identifier>ISSN: 0301-1623</identifier><identifier>EISSN: 1573-2584</identifier><identifier>DOI: 10.1007/s11255-022-03383-2</identifier><identifier>PMID: 36464759</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Drug therapy ; Hyperplasia ; Inflammation ; Interleukin 6 ; Low density lipoprotein ; Lycopene ; Medicine ; Medicine & Public Health ; Nephrology ; Obesity ; Oxidative stress ; Prostate ; Testosterone ; Urology ; Urology - Original Paper</subject><ispartof>International urology and nephrology, 2023-03, Vol.55 (3), p.529-539</ispartof><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2022. The Author(s), under exclusive licence to Springer Nature B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-593b2a8fb9b26d6b5d4e7b68f76c38fc5fda2ce9aabd168c83245b9cc8ed2a83</citedby><cites>FETCH-LOGICAL-c375t-593b2a8fb9b26d6b5d4e7b68f76c38fc5fda2ce9aabd168c83245b9cc8ed2a83</cites><orcidid>0000-0002-2730-7761</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11255-022-03383-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11255-022-03383-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27911,27912,41475,42544,51306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36464759$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Colado-Velázquez, Juventino III</creatorcontrib><creatorcontrib>Mailloux-Salinas, Patrick</creatorcontrib><creatorcontrib>Arias-Chávez, David Julian</creatorcontrib><creatorcontrib>Ledesma-Aparicio, Jessica</creatorcontrib><creatorcontrib>Gómez-Viquez, Norma Leticia</creatorcontrib><creatorcontrib>Cano-Europa, Edgard</creatorcontrib><creatorcontrib>Sarabia, Gabriel Noris</creatorcontrib><creatorcontrib>Bravo, Guadalupe</creatorcontrib><title>Lipidic extract of whole tomato reduces hyperplasia, oxidative stress and inflammation on testosterone-induced BPH in obese rats</title><title>International urology and nephrology</title><addtitle>Int Urol Nephrol</addtitle><addtitle>Int Urol Nephrol</addtitle><description>Purpose
Tomato is an important source of lycopene, a carotenoid that has been emerging as a natural preventive agent for prostate disease. Moreover, tomato contains other components with a wide range of physiological properties, but their potential beneficial effects on prostatic hyperplasia (PH) during obesity have not been completely established. In this study, we compared the effect of a lipidic extract of tomato saladette (STE) with
Serenoa repens
(
SR
) on obese rats with PH.
Methods
Forty-eight Wistar rats were divided in Control (C) and Obese (Ob) treated without (
n
= 12) and with (
n
= 36) testosterone enanthate (TE), once a week for 8 weeks to induce PH. After 4 weeks,
SR
and STE were administered. Biochemical parameters, oxidative stress markers and inflammatory cytokines production were determined.
Results
TE increased prostate weight and caused prostatic hyperplasia in C group, and these effects were exacerbated by obesity.
SR
and STE reverted the increase in prostate weight and hyperplasia caused by TE in C and Ob groups. Obesity increased LDL, TGs, NOx and MAD, but decreased HDLc, GSx, SOD and CAT.
SR
reverted the effects of obesity, but these were significantly reduced and HDLc increased with STE. Obesity and TE increased TNFα, IL-1β and IL-6 levels, but these were partially reverted by STE compared with
SR
.
Conclusions
Excess of fat tissue increases the alterations by PH. STE diminishes these alterations compared with
SR
, suggesting its beneficial effect to improve prostate function. Whole tomato lipid extract could serve as sole therapy or as an adjunct to pharmacological treatment for PH.</description><subject>Drug therapy</subject><subject>Hyperplasia</subject><subject>Inflammation</subject><subject>Interleukin 6</subject><subject>Low density lipoprotein</subject><subject>Lycopene</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nephrology</subject><subject>Obesity</subject><subject>Oxidative stress</subject><subject>Prostate</subject><subject>Testosterone</subject><subject>Urology</subject><subject>Urology - Original Paper</subject><issn>1573-2584</issn><issn>0301-1623</issn><issn>1573-2584</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kctu1jAQhS1ERUvhBVggS2xYNMWx49hZQkUp0i_BonvLlwl1lcTB45R2x6Pj8peLWCCNNCP5O2dGPoS8aNlpy5h6g23LpWwY5w0TQouGPyJHrVR1kLp7_Nd8SJ4iXjPGBs3YE3Io-q7vlByOyPddXGOInsJtydYXmkb67SpNQEuabUk0Q9g8IL26WyGvk8VoT2i6jcGWeAMUSwZEapdA4zJOdq6imBZaqwCWhAVyWqCJy71NoO8-X1SQJgcINNuCz8jBaCeE5w_9mFyev788u2h2nz58PHu7a7xQsjRyEI5bPbrB8T70ToYOlOv1qHov9OjlGCz3MFjrQttrrwXvpBu81xCqThyT13vbNaevW73MzBE9TJNdIG1ouOpU_VPVtRV99Q96nba81OMqpQbFhO6GSvE95XNCzDCaNcfZ5jvTMnMfj9nHY2o85mc8hlfRywfrzc0Qfkt-5VEBsQewPi1fIP_Z_R_bH0PTnZs</recordid><startdate>20230301</startdate><enddate>20230301</enddate><creator>Colado-Velázquez, Juventino III</creator><creator>Mailloux-Salinas, Patrick</creator><creator>Arias-Chávez, David Julian</creator><creator>Ledesma-Aparicio, Jessica</creator><creator>Gómez-Viquez, Norma Leticia</creator><creator>Cano-Europa, Edgard</creator><creator>Sarabia, Gabriel Noris</creator><creator>Bravo, Guadalupe</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2730-7761</orcidid></search><sort><creationdate>20230301</creationdate><title>Lipidic extract of whole tomato reduces hyperplasia, oxidative stress and inflammation on testosterone-induced BPH in obese rats</title><author>Colado-Velázquez, Juventino III ; Mailloux-Salinas, Patrick ; Arias-Chávez, David Julian ; Ledesma-Aparicio, Jessica ; Gómez-Viquez, Norma Leticia ; Cano-Europa, Edgard ; Sarabia, Gabriel Noris ; Bravo, Guadalupe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-593b2a8fb9b26d6b5d4e7b68f76c38fc5fda2ce9aabd168c83245b9cc8ed2a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Drug therapy</topic><topic>Hyperplasia</topic><topic>Inflammation</topic><topic>Interleukin 6</topic><topic>Low density lipoprotein</topic><topic>Lycopene</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nephrology</topic><topic>Obesity</topic><topic>Oxidative stress</topic><topic>Prostate</topic><topic>Testosterone</topic><topic>Urology</topic><topic>Urology - Original Paper</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Colado-Velázquez, Juventino III</creatorcontrib><creatorcontrib>Mailloux-Salinas, Patrick</creatorcontrib><creatorcontrib>Arias-Chávez, David Julian</creatorcontrib><creatorcontrib>Ledesma-Aparicio, Jessica</creatorcontrib><creatorcontrib>Gómez-Viquez, Norma Leticia</creatorcontrib><creatorcontrib>Cano-Europa, Edgard</creatorcontrib><creatorcontrib>Sarabia, Gabriel Noris</creatorcontrib><creatorcontrib>Bravo, Guadalupe</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>International urology and nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Colado-Velázquez, Juventino III</au><au>Mailloux-Salinas, Patrick</au><au>Arias-Chávez, David Julian</au><au>Ledesma-Aparicio, Jessica</au><au>Gómez-Viquez, Norma Leticia</au><au>Cano-Europa, Edgard</au><au>Sarabia, Gabriel Noris</au><au>Bravo, Guadalupe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lipidic extract of whole tomato reduces hyperplasia, oxidative stress and inflammation on testosterone-induced BPH in obese rats</atitle><jtitle>International urology and nephrology</jtitle><stitle>Int Urol Nephrol</stitle><addtitle>Int Urol Nephrol</addtitle><date>2023-03-01</date><risdate>2023</risdate><volume>55</volume><issue>3</issue><spage>529</spage><epage>539</epage><pages>529-539</pages><issn>1573-2584</issn><issn>0301-1623</issn><eissn>1573-2584</eissn><abstract>Purpose
Tomato is an important source of lycopene, a carotenoid that has been emerging as a natural preventive agent for prostate disease. Moreover, tomato contains other components with a wide range of physiological properties, but their potential beneficial effects on prostatic hyperplasia (PH) during obesity have not been completely established. In this study, we compared the effect of a lipidic extract of tomato saladette (STE) with
Serenoa repens
(
SR
) on obese rats with PH.
Methods
Forty-eight Wistar rats were divided in Control (C) and Obese (Ob) treated without (
n
= 12) and with (
n
= 36) testosterone enanthate (TE), once a week for 8 weeks to induce PH. After 4 weeks,
SR
and STE were administered. Biochemical parameters, oxidative stress markers and inflammatory cytokines production were determined.
Results
TE increased prostate weight and caused prostatic hyperplasia in C group, and these effects were exacerbated by obesity.
SR
and STE reverted the increase in prostate weight and hyperplasia caused by TE in C and Ob groups. Obesity increased LDL, TGs, NOx and MAD, but decreased HDLc, GSx, SOD and CAT.
SR
reverted the effects of obesity, but these were significantly reduced and HDLc increased with STE. Obesity and TE increased TNFα, IL-1β and IL-6 levels, but these were partially reverted by STE compared with
SR
.
Conclusions
Excess of fat tissue increases the alterations by PH. STE diminishes these alterations compared with
SR
, suggesting its beneficial effect to improve prostate function. Whole tomato lipid extract could serve as sole therapy or as an adjunct to pharmacological treatment for PH.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>36464759</pmid><doi>10.1007/s11255-022-03383-2</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-2730-7761</orcidid></addata></record> |
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| source | Springer Nature - Complete Springer Journals |
| subjects | Drug therapy Hyperplasia Inflammation Interleukin 6 Low density lipoprotein Lycopene Medicine Medicine & Public Health Nephrology Obesity Oxidative stress Prostate Testosterone Urology Urology - Original Paper |
| title | Lipidic extract of whole tomato reduces hyperplasia, oxidative stress and inflammation on testosterone-induced BPH in obese rats |
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