Pyrimidine derivatives with antitubercular activity

Small molecules with antitubercular activity containing the pyrimidine motif in their structure have gained more attention after three drugs, namely GSK 2556286 (GSK-286), TBA-7371 and SPR720, have entered clinical trials. This review provides an overview of recent advances in the hit-to-lead drug d...

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Veröffentlicht in:	European journal of medicinal chemistry 2023-01, Vol.246, p.114946-114946, Article 114946
Hauptverfasser:	Finger, Vladimir, Kufa, Martin, Soukup, Ondrej, Castagnolo, Daniele, Roh, Jaroslav, Korabecny, Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	Antitubercular Agents - chemistry Drug development Drug Discovery Mycobacterium tuberculosis Pyrimidine Pyrimidines - pharmacology Structure-Activity Relationship Structure-activity relationships Tuberculosis
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