Cytochrome P450 Catalyzes Benzene Ring Formation in the Biosynthesis of Trialkyl‐Substituted Aromatic Polyketides

Lorneic acid and related natural products are characterized by a trialkyl‐substituted benzene ring. The formation of the aromatic core in the middle of the polyketide chain is unusual. We characterized a cytochrome P450 enzyme that can catalyze the hallmark benzene ring formation from an acyclic pol...

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Veröffentlicht in:	Angewandte Chemie International Edition 2023-01, Vol.62 (5), p.e202214026-n/a
Hauptverfasser:	Yang, Yu Meng, Zhao, Er Juan, Wei, Wanqing, Xu, Zi Fei, Shi, Jing, Wu, Xuan, Zhang, Bo, Igarashi, Yasuhiro, Jiao, Rui Hua, Liang, Yong, Tan, Ren Xiang, Ge, Hui Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Aromatic Polyketides Benzene Benzene Ring Formation Biochemical analysis Biosynthesis Cytochrome Cytochrome P-450 Enzyme System Cytochrome P450 Cytochromes P450 Cytochrome P450 Enzymes Gene clusters Genetic analysis Genomes Natural products Polyenes Polyketide synthase Polyketide Synthases - genetics Polyketide Synthases - metabolism Polyketides Polyketides - chemistry Quantum chemistry Secondary Metabolism Substitutes Substrates
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