The immediate effect of overnutrition and fluoxetine treatment during the critical period of development on the hippocampus
It is well known that overnutrition, overweight, and obesity in children can modulate brain mechanisms of plasticity, monoaminergic systems, and mitochondrial function. The immediate effect of overnutrition during the developmental period has not been thoroughly examined in rats until the present. T...
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| Veröffentlicht in: | Neurochemistry international 2023-01, Vol.162, p.105454-105454, Article 105454 |
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| creator | de Andrade Silva, Severina Cassia de Lemos, Maria Daniele Teixeira Santos-Junior, Osmar Henrique Rodrigues, Thyago de Oliveira Silva, Tercya Lucidi Tavares, Gabriel A. da Silva, Aline Isabel Lagranha, Claudia J. |
| description | It is well known that overnutrition, overweight, and obesity in children can modulate brain mechanisms of plasticity, monoaminergic systems, and mitochondrial function. The immediate effect of overnutrition during the developmental period has not been thoroughly examined in rats until the present. This study sought to evaluate the impact on adult rats of early life overfeeding and fluoxetine treatment from post-natal day 1 (PND1) to post-natal day 21 (PND21) relative to mitochondrial function, oxidative balance, and expression of specific monoaminergic genes in the hippocampus. The following were evaluated: mitochondrial function markers, oxidative stress biomarkers, dopamine-and serotonin-related genes, and BDNF mRNA levels. Overfeeding during the lactation period deregulates cellular metabolism and the monoaminergic systems in the hippocampus. Strikingly, serotonin modulation by fluoxetine treatment protected against some of the effects of early overnutrition. We conclude that overfeeding during brain development induce detrimental effects in mitochondria and in the genes that regulate homeostatic status that can be the molecular mechanisms related to neurological diseases.
•Overfed during development induce deleterious effect in hippocampus.•Overfed during lactation deregulates mitochondrial function and the hippocampus's monoaminergic systems.•Fluoxetine treatment can decrease de detrimental effect of overnutrition.•Fluoxetine can improve hippocampus function by increase antioxidant defense. |
| doi_str_mv | 10.1016/j.neuint.2022.105454 |
| format | Article |
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•Overfed during development induce deleterious effect in hippocampus.•Overfed during lactation deregulates mitochondrial function and the hippocampus's monoaminergic systems.•Fluoxetine treatment can decrease de detrimental effect of overnutrition.•Fluoxetine can improve hippocampus function by increase antioxidant defense.</description><identifier>ISSN: 0197-0186</identifier><identifier>EISSN: 1872-9754</identifier><identifier>DOI: 10.1016/j.neuint.2022.105454</identifier><identifier>PMID: 36462683</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Female ; Fluoxetine ; Fluoxetine - pharmacology ; Fluoxetine - therapeutic use ; Hippocampus ; Hippocampus - drug effects ; Hippocampus - metabolism ; Mitochondria - metabolism ; Mitochondria - pathology ; Mitochondrial function ; Overfeeding ; Overnutrition - metabolism ; Overnutrition - physiopathology ; Oxidative balance ; Pediatric Obesity - metabolism ; Rats ; Serotonin - metabolism</subject><ispartof>Neurochemistry international, 2023-01, Vol.162, p.105454-105454, Article 105454</ispartof><rights>2022 Elsevier Ltd</rights><rights>Copyright © 2022 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c292t-188b35e9dd1c342305c24466ddf0633438af308b868820a62c09e1ecb30b77223</citedby><cites>FETCH-LOGICAL-c292t-188b35e9dd1c342305c24466ddf0633438af308b868820a62c09e1ecb30b77223</cites><orcidid>0000-0001-6883-9476</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0197018622001796$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36462683$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Andrade Silva, Severina Cassia</creatorcontrib><creatorcontrib>de Lemos, Maria Daniele Teixeira</creatorcontrib><creatorcontrib>Santos-Junior, Osmar Henrique</creatorcontrib><creatorcontrib>Rodrigues, Thyago de Oliveira</creatorcontrib><creatorcontrib>Silva, Tercya Lucidi</creatorcontrib><creatorcontrib>Tavares, Gabriel A.</creatorcontrib><creatorcontrib>da Silva, Aline Isabel</creatorcontrib><creatorcontrib>Lagranha, Claudia J.</creatorcontrib><title>The immediate effect of overnutrition and fluoxetine treatment during the critical period of development on the hippocampus</title><title>Neurochemistry international</title><addtitle>Neurochem Int</addtitle><description>It is well known that overnutrition, overweight, and obesity in children can modulate brain mechanisms of plasticity, monoaminergic systems, and mitochondrial function. The immediate effect of overnutrition during the developmental period has not been thoroughly examined in rats until the present. This study sought to evaluate the impact on adult rats of early life overfeeding and fluoxetine treatment from post-natal day 1 (PND1) to post-natal day 21 (PND21) relative to mitochondrial function, oxidative balance, and expression of specific monoaminergic genes in the hippocampus. The following were evaluated: mitochondrial function markers, oxidative stress biomarkers, dopamine-and serotonin-related genes, and BDNF mRNA levels. Overfeeding during the lactation period deregulates cellular metabolism and the monoaminergic systems in the hippocampus. Strikingly, serotonin modulation by fluoxetine treatment protected against some of the effects of early overnutrition. We conclude that overfeeding during brain development induce detrimental effects in mitochondria and in the genes that regulate homeostatic status that can be the molecular mechanisms related to neurological diseases.
•Overfed during development induce deleterious effect in hippocampus.•Overfed during lactation deregulates mitochondrial function and the hippocampus's monoaminergic systems.•Fluoxetine treatment can decrease de detrimental effect of overnutrition.•Fluoxetine can improve hippocampus function by increase antioxidant defense.</description><subject>Animals</subject><subject>Female</subject><subject>Fluoxetine</subject><subject>Fluoxetine - pharmacology</subject><subject>Fluoxetine - therapeutic use</subject><subject>Hippocampus</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - metabolism</subject><subject>Mitochondria - metabolism</subject><subject>Mitochondria - pathology</subject><subject>Mitochondrial function</subject><subject>Overfeeding</subject><subject>Overnutrition - metabolism</subject><subject>Overnutrition - physiopathology</subject><subject>Oxidative balance</subject><subject>Pediatric Obesity - metabolism</subject><subject>Rats</subject><subject>Serotonin - metabolism</subject><issn>0197-0186</issn><issn>1872-9754</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE2L1TAUhoM4ONfRfyCSpZte89U03Qgy-AUDs5lZhzQ5dXJpk5qkF2X-vKkdXbo6cHje93AehN5QcqSEyvenY4DVh3JkhLG6akUrnqEDVR1r-q4Vz9GB0L5rCFXyEr3M-UQI6XrSvkCXXArJpOIH9Hj3ANjPMzhvCmAYR7AFxxHHM6SwluSLjwGb4PA4rfEnFB8AlwSmzBAKdmvy4TsutcVurDUTXiD56LYSB2eY4vKHrC0b9eCXJVozL2t-hS5GM2V4_TSv0P3nT3fXX5ub2y_frj_eNJb1rDRUqYG30DtHLReMk9YyIaR0biSSc8GVGTlRg5JKMWIks6QHCnbgZOg6xvgVerf3Lin-WCEXPftsYZpMgLhmzTohec95t6FiR22KOScY9ZL8bNIvTYnetOuT3rXrTbvetdfY26cL61BV_gv99VyBDzsA9c-zh6Sz9RBs1Z6qcO2i__-F3-Jyl00</recordid><startdate>202301</startdate><enddate>202301</enddate><creator>de Andrade Silva, Severina Cassia</creator><creator>de Lemos, Maria Daniele Teixeira</creator><creator>Santos-Junior, Osmar Henrique</creator><creator>Rodrigues, Thyago de Oliveira</creator><creator>Silva, Tercya Lucidi</creator><creator>Tavares, Gabriel A.</creator><creator>da Silva, Aline Isabel</creator><creator>Lagranha, Claudia J.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6883-9476</orcidid></search><sort><creationdate>202301</creationdate><title>The immediate effect of overnutrition and fluoxetine treatment during the critical period of development on the hippocampus</title><author>de Andrade Silva, Severina Cassia ; de Lemos, Maria Daniele Teixeira ; Santos-Junior, Osmar Henrique ; Rodrigues, Thyago de Oliveira ; Silva, Tercya Lucidi ; Tavares, Gabriel A. ; da Silva, Aline Isabel ; Lagranha, Claudia J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c292t-188b35e9dd1c342305c24466ddf0633438af308b868820a62c09e1ecb30b77223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Animals</topic><topic>Female</topic><topic>Fluoxetine</topic><topic>Fluoxetine - pharmacology</topic><topic>Fluoxetine - therapeutic use</topic><topic>Hippocampus</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - metabolism</topic><topic>Mitochondria - metabolism</topic><topic>Mitochondria - pathology</topic><topic>Mitochondrial function</topic><topic>Overfeeding</topic><topic>Overnutrition - metabolism</topic><topic>Overnutrition - physiopathology</topic><topic>Oxidative balance</topic><topic>Pediatric Obesity - metabolism</topic><topic>Rats</topic><topic>Serotonin - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Andrade Silva, Severina Cassia</creatorcontrib><creatorcontrib>de Lemos, Maria Daniele Teixeira</creatorcontrib><creatorcontrib>Santos-Junior, Osmar Henrique</creatorcontrib><creatorcontrib>Rodrigues, Thyago de Oliveira</creatorcontrib><creatorcontrib>Silva, Tercya Lucidi</creatorcontrib><creatorcontrib>Tavares, Gabriel A.</creatorcontrib><creatorcontrib>da Silva, Aline Isabel</creatorcontrib><creatorcontrib>Lagranha, Claudia J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neurochemistry international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Andrade Silva, Severina Cassia</au><au>de Lemos, Maria Daniele Teixeira</au><au>Santos-Junior, Osmar Henrique</au><au>Rodrigues, Thyago de Oliveira</au><au>Silva, Tercya Lucidi</au><au>Tavares, Gabriel A.</au><au>da Silva, Aline Isabel</au><au>Lagranha, Claudia J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The immediate effect of overnutrition and fluoxetine treatment during the critical period of development on the hippocampus</atitle><jtitle>Neurochemistry international</jtitle><addtitle>Neurochem Int</addtitle><date>2023-01</date><risdate>2023</risdate><volume>162</volume><spage>105454</spage><epage>105454</epage><pages>105454-105454</pages><artnum>105454</artnum><issn>0197-0186</issn><eissn>1872-9754</eissn><abstract>It is well known that overnutrition, overweight, and obesity in children can modulate brain mechanisms of plasticity, monoaminergic systems, and mitochondrial function. The immediate effect of overnutrition during the developmental period has not been thoroughly examined in rats until the present. This study sought to evaluate the impact on adult rats of early life overfeeding and fluoxetine treatment from post-natal day 1 (PND1) to post-natal day 21 (PND21) relative to mitochondrial function, oxidative balance, and expression of specific monoaminergic genes in the hippocampus. The following were evaluated: mitochondrial function markers, oxidative stress biomarkers, dopamine-and serotonin-related genes, and BDNF mRNA levels. Overfeeding during the lactation period deregulates cellular metabolism and the monoaminergic systems in the hippocampus. Strikingly, serotonin modulation by fluoxetine treatment protected against some of the effects of early overnutrition. We conclude that overfeeding during brain development induce detrimental effects in mitochondria and in the genes that regulate homeostatic status that can be the molecular mechanisms related to neurological diseases.
•Overfed during development induce deleterious effect in hippocampus.•Overfed during lactation deregulates mitochondrial function and the hippocampus's monoaminergic systems.•Fluoxetine treatment can decrease de detrimental effect of overnutrition.•Fluoxetine can improve hippocampus function by increase antioxidant defense.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>36462683</pmid><doi>10.1016/j.neuint.2022.105454</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-6883-9476</orcidid></addata></record> |
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| subjects | Animals Female Fluoxetine Fluoxetine - pharmacology Fluoxetine - therapeutic use Hippocampus Hippocampus - drug effects Hippocampus - metabolism Mitochondria - metabolism Mitochondria - pathology Mitochondrial function Overfeeding Overnutrition - metabolism Overnutrition - physiopathology Oxidative balance Pediatric Obesity - metabolism Rats Serotonin - metabolism |
| title | The immediate effect of overnutrition and fluoxetine treatment during the critical period of development on the hippocampus |
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