Mutations in SARS-CoV-2 spike protein impair epitope-specific CD4+ T cell recognition
CD4 + T cells are essential for protection against viruses, including SARS-CoV-2. The sensitivity of CD4 + T cells to mutations in SARS-CoV-2 variants of concern (VOCs) is poorly understood. Here, we isolated 159 SARS-CoV-2-specific CD4 + T cell clones from healthcare workers previously infected wit...
Gespeichert in:
Veröffentlicht in: | Nature immunology 2022-12, Vol.23 (12), p.1726-1734 |
---|---|
Hauptverfasser: | , , , , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 1734 |
---|---|
container_issue | 12 |
container_start_page | 1726 |
container_title | Nature immunology |
container_volume | 23 |
creator | Tye, Emily X. C. Jinks, Elizabeth Haigh, Tracey A. Kaul, Baksho Patel, Prashant Parry, Helen M. Newby, Maddy L. Crispin, Max Kaur, Nayandeep Moss, Paul Drennan, Samantha J. Taylor, Graham S. Long, Heather M. |
description | CD4
+
T cells are essential for protection against viruses, including SARS-CoV-2. The sensitivity of CD4
+
T cells to mutations in SARS-CoV-2 variants of concern (VOCs) is poorly understood. Here, we isolated 159 SARS-CoV-2-specific CD4
+
T cell clones from healthcare workers previously infected with wild-type SARS-CoV-2 (D614G) and defined 21 epitopes in spike, membrane and nucleoprotein. Lack of CD4
+
T cell cross-reactivity between SARS-CoV-2 and endemic beta-coronaviruses suggested these responses arose from naïve rather than pre-existing cross-reactive coronavirus-specific T cells. Of the 17 epitopes located in the spike protein, 10 were mutated in VOCs and CD4
+
T cell clone recognition of 7 of them was impaired, including 3 of the 4 epitopes mutated in omicron. Our results indicated that broad targeting of epitopes by CD4
+
T cells likely limits evasion by current VOCs. However, continued genomic surveillance is vital to identify new mutations able to evade CD4
+
T cell immunity.
Based on the identification of CD4
+
T cell clones specific for distinct epitopes in the SARS-CoV-2 proteins, Long and colleagues characterize how mutations in these epitopes lead to loss of recognition by the CD4
+
T cells elicited by natural infection or vaccination. |
doi_str_mv | 10.1038/s41590-022-01351-7 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2746389833</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2746389833</sourcerecordid><originalsourceid>FETCH-LOGICAL-c419t-b53191ef834f442ab623129a0455001329910e87558c39980f447547fe71a123</originalsourceid><addsrcrecordid>eNp9kE1LAzEURYMotlb_gAsJuBEkms9JsizjJ1QEW92GdMyU1HZmTGYW_ntTpyq4cJUH77ybywHgmOALgpm6jJwIjRGmFGHCBEFyBwyJoBpRTbLdnxmrATiIcYkx4TLj-2DAMi4yycQQPD90rW19XUXoKzgdP01RXr8gCmPj3xxsQt26tPDrxvoAXePbunEoNq7wpS9gfsXP4QwWbrWCwRX1ovKbsEOwV9pVdEfbdwRmN9ez_A5NHm_v8_EEFZzoFs0FI5q4UjFeck7tPKOMUG0xFyKVZVRrgp2SQqiCaa1woqTgsnSSWELZCJz1sanme-dia9Y-brrYytVdNFTyjCmtGEvo6R90WXehSuUSJZjGVLMsUbSnilDHGFxpmuDXNnwYgs3Guemdm-TcfDk3Mh2dbKO7-dq9_px8S04A64GYVtXChd-__4n9BIOFiD8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2753902936</pqid></control><display><type>article</type><title>Mutations in SARS-CoV-2 spike protein impair epitope-specific CD4+ T cell recognition</title><source>MEDLINE</source><source>Nature</source><source>Alma/SFX Local Collection</source><creator>Tye, Emily X. C. ; Jinks, Elizabeth ; Haigh, Tracey A. ; Kaul, Baksho ; Patel, Prashant ; Parry, Helen M. ; Newby, Maddy L. ; Crispin, Max ; Kaur, Nayandeep ; Moss, Paul ; Drennan, Samantha J. ; Taylor, Graham S. ; Long, Heather M.</creator><creatorcontrib>Tye, Emily X. C. ; Jinks, Elizabeth ; Haigh, Tracey A. ; Kaul, Baksho ; Patel, Prashant ; Parry, Helen M. ; Newby, Maddy L. ; Crispin, Max ; Kaur, Nayandeep ; Moss, Paul ; Drennan, Samantha J. ; Taylor, Graham S. ; Long, Heather M.</creatorcontrib><description>CD4
+
T cells are essential for protection against viruses, including SARS-CoV-2. The sensitivity of CD4
+
T cells to mutations in SARS-CoV-2 variants of concern (VOCs) is poorly understood. Here, we isolated 159 SARS-CoV-2-specific CD4
+
T cell clones from healthcare workers previously infected with wild-type SARS-CoV-2 (D614G) and defined 21 epitopes in spike, membrane and nucleoprotein. Lack of CD4
+
T cell cross-reactivity between SARS-CoV-2 and endemic beta-coronaviruses suggested these responses arose from naïve rather than pre-existing cross-reactive coronavirus-specific T cells. Of the 17 epitopes located in the spike protein, 10 were mutated in VOCs and CD4
+
T cell clone recognition of 7 of them was impaired, including 3 of the 4 epitopes mutated in omicron. Our results indicated that broad targeting of epitopes by CD4
+
T cells likely limits evasion by current VOCs. However, continued genomic surveillance is vital to identify new mutations able to evade CD4
+
T cell immunity.
Based on the identification of CD4
+
T cell clones specific for distinct epitopes in the SARS-CoV-2 proteins, Long and colleagues characterize how mutations in these epitopes lead to loss of recognition by the CD4
+
T cells elicited by natural infection or vaccination.</description><identifier>ISSN: 1529-2908</identifier><identifier>EISSN: 1529-2916</identifier><identifier>DOI: 10.1038/s41590-022-01351-7</identifier><identifier>PMID: 36456735</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>631/250/255/2514 ; 692/699/255/2514 ; Biomedical and Life Sciences ; Biomedicine ; CD4 antigen ; CD4-Positive T-Lymphocytes ; Cell recognition ; Coronaviruses ; COVID-19 ; Cross-reactivity ; Epitopes ; Epitopes, T-Lymphocyte - genetics ; Humans ; Immunology ; Infectious Diseases ; Lymphocytes ; Lymphocytes T ; Medical personnel ; Mutation ; SARS-CoV-2 ; Severe acute respiratory syndrome coronavirus 2 ; Spike Glycoprotein, Coronavirus - genetics ; Spike protein ; T-Lymphocytes ; Vaccination</subject><ispartof>Nature immunology, 2022-12, Vol.23 (12), p.1726-1734</ispartof><rights>The Author(s), under exclusive licence to Springer Nature America, Inc. 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2022. The Author(s), under exclusive licence to Springer Nature America, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-b53191ef834f442ab623129a0455001329910e87558c39980f447547fe71a123</citedby><cites>FETCH-LOGICAL-c419t-b53191ef834f442ab623129a0455001329910e87558c39980f447547fe71a123</cites><orcidid>0000-0002-5945-343X ; 0000-0003-2139-8292 ; 0000-0002-2882-5990 ; 0000-0002-4807-2797 ; 0000-0002-6895-1967 ; 0000-0002-1072-2694</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36456735$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tye, Emily X. C.</creatorcontrib><creatorcontrib>Jinks, Elizabeth</creatorcontrib><creatorcontrib>Haigh, Tracey A.</creatorcontrib><creatorcontrib>Kaul, Baksho</creatorcontrib><creatorcontrib>Patel, Prashant</creatorcontrib><creatorcontrib>Parry, Helen M.</creatorcontrib><creatorcontrib>Newby, Maddy L.</creatorcontrib><creatorcontrib>Crispin, Max</creatorcontrib><creatorcontrib>Kaur, Nayandeep</creatorcontrib><creatorcontrib>Moss, Paul</creatorcontrib><creatorcontrib>Drennan, Samantha J.</creatorcontrib><creatorcontrib>Taylor, Graham S.</creatorcontrib><creatorcontrib>Long, Heather M.</creatorcontrib><title>Mutations in SARS-CoV-2 spike protein impair epitope-specific CD4+ T cell recognition</title><title>Nature immunology</title><addtitle>Nat Immunol</addtitle><addtitle>Nat Immunol</addtitle><description>CD4
+
T cells are essential for protection against viruses, including SARS-CoV-2. The sensitivity of CD4
+
T cells to mutations in SARS-CoV-2 variants of concern (VOCs) is poorly understood. Here, we isolated 159 SARS-CoV-2-specific CD4
+
T cell clones from healthcare workers previously infected with wild-type SARS-CoV-2 (D614G) and defined 21 epitopes in spike, membrane and nucleoprotein. Lack of CD4
+
T cell cross-reactivity between SARS-CoV-2 and endemic beta-coronaviruses suggested these responses arose from naïve rather than pre-existing cross-reactive coronavirus-specific T cells. Of the 17 epitopes located in the spike protein, 10 were mutated in VOCs and CD4
+
T cell clone recognition of 7 of them was impaired, including 3 of the 4 epitopes mutated in omicron. Our results indicated that broad targeting of epitopes by CD4
+
T cells likely limits evasion by current VOCs. However, continued genomic surveillance is vital to identify new mutations able to evade CD4
+
T cell immunity.
Based on the identification of CD4
+
T cell clones specific for distinct epitopes in the SARS-CoV-2 proteins, Long and colleagues characterize how mutations in these epitopes lead to loss of recognition by the CD4
+
T cells elicited by natural infection or vaccination.</description><subject>631/250/255/2514</subject><subject>692/699/255/2514</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>CD4 antigen</subject><subject>CD4-Positive T-Lymphocytes</subject><subject>Cell recognition</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>Cross-reactivity</subject><subject>Epitopes</subject><subject>Epitopes, T-Lymphocyte - genetics</subject><subject>Humans</subject><subject>Immunology</subject><subject>Infectious Diseases</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Medical personnel</subject><subject>Mutation</subject><subject>SARS-CoV-2</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Spike Glycoprotein, Coronavirus - genetics</subject><subject>Spike protein</subject><subject>T-Lymphocytes</subject><subject>Vaccination</subject><issn>1529-2908</issn><issn>1529-2916</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kE1LAzEURYMotlb_gAsJuBEkms9JsizjJ1QEW92GdMyU1HZmTGYW_ntTpyq4cJUH77ybywHgmOALgpm6jJwIjRGmFGHCBEFyBwyJoBpRTbLdnxmrATiIcYkx4TLj-2DAMi4yycQQPD90rW19XUXoKzgdP01RXr8gCmPj3xxsQt26tPDrxvoAXePbunEoNq7wpS9gfsXP4QwWbrWCwRX1ovKbsEOwV9pVdEfbdwRmN9ez_A5NHm_v8_EEFZzoFs0FI5q4UjFeck7tPKOMUG0xFyKVZVRrgp2SQqiCaa1woqTgsnSSWELZCJz1sanme-dia9Y-brrYytVdNFTyjCmtGEvo6R90WXehSuUSJZjGVLMsUbSnilDHGFxpmuDXNnwYgs3Guemdm-TcfDk3Mh2dbKO7-dq9_px8S04A64GYVtXChd-__4n9BIOFiD8</recordid><startdate>20221201</startdate><enddate>20221201</enddate><creator>Tye, Emily X. C.</creator><creator>Jinks, Elizabeth</creator><creator>Haigh, Tracey A.</creator><creator>Kaul, Baksho</creator><creator>Patel, Prashant</creator><creator>Parry, Helen M.</creator><creator>Newby, Maddy L.</creator><creator>Crispin, Max</creator><creator>Kaur, Nayandeep</creator><creator>Moss, Paul</creator><creator>Drennan, Samantha J.</creator><creator>Taylor, Graham S.</creator><creator>Long, Heather M.</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5945-343X</orcidid><orcidid>https://orcid.org/0000-0003-2139-8292</orcidid><orcidid>https://orcid.org/0000-0002-2882-5990</orcidid><orcidid>https://orcid.org/0000-0002-4807-2797</orcidid><orcidid>https://orcid.org/0000-0002-6895-1967</orcidid><orcidid>https://orcid.org/0000-0002-1072-2694</orcidid></search><sort><creationdate>20221201</creationdate><title>Mutations in SARS-CoV-2 spike protein impair epitope-specific CD4+ T cell recognition</title><author>Tye, Emily X. C. ; Jinks, Elizabeth ; Haigh, Tracey A. ; Kaul, Baksho ; Patel, Prashant ; Parry, Helen M. ; Newby, Maddy L. ; Crispin, Max ; Kaur, Nayandeep ; Moss, Paul ; Drennan, Samantha J. ; Taylor, Graham S. ; Long, Heather M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-b53191ef834f442ab623129a0455001329910e87558c39980f447547fe71a123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>631/250/255/2514</topic><topic>692/699/255/2514</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>CD4 antigen</topic><topic>CD4-Positive T-Lymphocytes</topic><topic>Cell recognition</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>Cross-reactivity</topic><topic>Epitopes</topic><topic>Epitopes, T-Lymphocyte - genetics</topic><topic>Humans</topic><topic>Immunology</topic><topic>Infectious Diseases</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Medical personnel</topic><topic>Mutation</topic><topic>SARS-CoV-2</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>Spike Glycoprotein, Coronavirus - genetics</topic><topic>Spike protein</topic><topic>T-Lymphocytes</topic><topic>Vaccination</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tye, Emily X. C.</creatorcontrib><creatorcontrib>Jinks, Elizabeth</creatorcontrib><creatorcontrib>Haigh, Tracey A.</creatorcontrib><creatorcontrib>Kaul, Baksho</creatorcontrib><creatorcontrib>Patel, Prashant</creatorcontrib><creatorcontrib>Parry, Helen M.</creatorcontrib><creatorcontrib>Newby, Maddy L.</creatorcontrib><creatorcontrib>Crispin, Max</creatorcontrib><creatorcontrib>Kaur, Nayandeep</creatorcontrib><creatorcontrib>Moss, Paul</creatorcontrib><creatorcontrib>Drennan, Samantha J.</creatorcontrib><creatorcontrib>Taylor, Graham S.</creatorcontrib><creatorcontrib>Long, Heather M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nature immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tye, Emily X. C.</au><au>Jinks, Elizabeth</au><au>Haigh, Tracey A.</au><au>Kaul, Baksho</au><au>Patel, Prashant</au><au>Parry, Helen M.</au><au>Newby, Maddy L.</au><au>Crispin, Max</au><au>Kaur, Nayandeep</au><au>Moss, Paul</au><au>Drennan, Samantha J.</au><au>Taylor, Graham S.</au><au>Long, Heather M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mutations in SARS-CoV-2 spike protein impair epitope-specific CD4+ T cell recognition</atitle><jtitle>Nature immunology</jtitle><stitle>Nat Immunol</stitle><addtitle>Nat Immunol</addtitle><date>2022-12-01</date><risdate>2022</risdate><volume>23</volume><issue>12</issue><spage>1726</spage><epage>1734</epage><pages>1726-1734</pages><issn>1529-2908</issn><eissn>1529-2916</eissn><abstract>CD4
+
T cells are essential for protection against viruses, including SARS-CoV-2. The sensitivity of CD4
+
T cells to mutations in SARS-CoV-2 variants of concern (VOCs) is poorly understood. Here, we isolated 159 SARS-CoV-2-specific CD4
+
T cell clones from healthcare workers previously infected with wild-type SARS-CoV-2 (D614G) and defined 21 epitopes in spike, membrane and nucleoprotein. Lack of CD4
+
T cell cross-reactivity between SARS-CoV-2 and endemic beta-coronaviruses suggested these responses arose from naïve rather than pre-existing cross-reactive coronavirus-specific T cells. Of the 17 epitopes located in the spike protein, 10 were mutated in VOCs and CD4
+
T cell clone recognition of 7 of them was impaired, including 3 of the 4 epitopes mutated in omicron. Our results indicated that broad targeting of epitopes by CD4
+
T cells likely limits evasion by current VOCs. However, continued genomic surveillance is vital to identify new mutations able to evade CD4
+
T cell immunity.
Based on the identification of CD4
+
T cell clones specific for distinct epitopes in the SARS-CoV-2 proteins, Long and colleagues characterize how mutations in these epitopes lead to loss of recognition by the CD4
+
T cells elicited by natural infection or vaccination.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>36456735</pmid><doi>10.1038/s41590-022-01351-7</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-5945-343X</orcidid><orcidid>https://orcid.org/0000-0003-2139-8292</orcidid><orcidid>https://orcid.org/0000-0002-2882-5990</orcidid><orcidid>https://orcid.org/0000-0002-4807-2797</orcidid><orcidid>https://orcid.org/0000-0002-6895-1967</orcidid><orcidid>https://orcid.org/0000-0002-1072-2694</orcidid><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1529-2908 |
ispartof | Nature immunology, 2022-12, Vol.23 (12), p.1726-1734 |
issn | 1529-2908 1529-2916 |
language | eng |
recordid | cdi_proquest_miscellaneous_2746389833 |
source | MEDLINE; Nature; Alma/SFX Local Collection |
subjects | 631/250/255/2514 692/699/255/2514 Biomedical and Life Sciences Biomedicine CD4 antigen CD4-Positive T-Lymphocytes Cell recognition Coronaviruses COVID-19 Cross-reactivity Epitopes Epitopes, T-Lymphocyte - genetics Humans Immunology Infectious Diseases Lymphocytes Lymphocytes T Medical personnel Mutation SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Spike Glycoprotein, Coronavirus - genetics Spike protein T-Lymphocytes Vaccination |
title | Mutations in SARS-CoV-2 spike protein impair epitope-specific CD4+ T cell recognition |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T07%3A58%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Mutations%20in%20SARS-CoV-2%20spike%20protein%20impair%20epitope-specific%20CD4+%20T%20cell%20recognition&rft.jtitle=Nature%20immunology&rft.au=Tye,%20Emily%20X.%20C.&rft.date=2022-12-01&rft.volume=23&rft.issue=12&rft.spage=1726&rft.epage=1734&rft.pages=1726-1734&rft.issn=1529-2908&rft.eissn=1529-2916&rft_id=info:doi/10.1038/s41590-022-01351-7&rft_dat=%3Cproquest_cross%3E2746389833%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2753902936&rft_id=info:pmid/36456735&rfr_iscdi=true |