In Vivo Fast Nonlinear Microscopy Reveals Impairment of Fast Axonal Transport Induced by Molecular Motor Imbalances in the Brain of Zebrafish Larvae

Cargo transport by molecular motors along microtubules is essential for the function of eukaryotic cells, in particular neurons in which axonal transport defects constitute the early pathological features of neurodegenerative diseases. Mainly studied in motor and sensory neurons, axonal transport is...

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Veröffentlicht in:	ACS nano 2022-12, Vol.16 (12), p.20470-20487
Hauptverfasser:	Grimaud, Baptiste, Frétaud, Maxence, Terras, Feriel, Bénassy, Antoine, Duroure, Karine, Bercier, Valérie, Trippé-Allard, Gaëlle, Mohammedi, Rabei, Gacoin, Thierry, Del Bene, Filippo, Marquier, François, Langevin, Christelle, Treussart, François
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axonal Transport - genetics Axons Brain - metabolism Dyneins - metabolism Kinesins - metabolism Larva - metabolism Microscopy Microtubules - metabolism Zebrafish - metabolism
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