Number of lymph nodes sampled in SFCE/SIOP 2001 patients with Wilms tumour: Is the goal of more than six achievable?
Aim The number of lymph nodes (LN) that should be sampled during nephrectomy for Wilms tumour (WT) remains controversial but of utmost importance for staging purposes. The aim of this French national retrospective study of patients enrolled in SIOPWT2001 trial was to analyse the number of LN sampled...
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| Veröffentlicht in: | Pediatric blood & cancer 2023-03, Vol.70 (3), p.e30107-n/a |
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| creator | Irtan, Sabine Coulomb‐Lhermine, Aurore Lanz, Camille Tabone, Marie‐Dominique Pasqualini, Claudia Dumont, Benoit Thebaud, Estelle Guellec, Isabelle Verschuur, Arnauld |
| description | Aim
The number of lymph nodes (LN) that should be sampled during nephrectomy for Wilms tumour (WT) remains controversial but of utmost importance for staging purposes. The aim of this French national retrospective study of patients enrolled in SIOPWT2001 trial was to analyse the number of LN sampled according to their site and to determine if the number of six asked by the International Society of Paediatric Oncology ‐ Renal Tumour Study Group (SIOP‐RTSG) UMBRELLA protocol is achievable.
Methods
We reviewed the data collected on central pathology review forms from 2002 to 2014 for only unilateral WT. LN were divided whether they were clearly identified by surgeons at nephrectomy or only found by pathologists on the nephrectomy specimen.
Results
A total of 539 patients (240 male/299 female) were included (458 localized/81 metastatic). Median age at surgery was 41.3 months [0–189]. The number of LN sampled was 0, 1–6, ≥7 and unknown in 69 (12.8%), 293 (54.3%), 160 (29.7%) and 17 (3.2%) cases, respectively. The number of patients with sampled LN were higher if LN were identified by both the pathologist and the surgeon (n = 231, 42.8%) (p = |
| doi_str_mv | 10.1002/pbc.30107 |
| format | Article |
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The number of lymph nodes (LN) that should be sampled during nephrectomy for Wilms tumour (WT) remains controversial but of utmost importance for staging purposes. The aim of this French national retrospective study of patients enrolled in SIOPWT2001 trial was to analyse the number of LN sampled according to their site and to determine if the number of six asked by the International Society of Paediatric Oncology ‐ Renal Tumour Study Group (SIOP‐RTSG) UMBRELLA protocol is achievable.
Methods
We reviewed the data collected on central pathology review forms from 2002 to 2014 for only unilateral WT. LN were divided whether they were clearly identified by surgeons at nephrectomy or only found by pathologists on the nephrectomy specimen.
Results
A total of 539 patients (240 male/299 female) were included (458 localized/81 metastatic). Median age at surgery was 41.3 months [0–189]. The number of LN sampled was 0, 1–6, ≥7 and unknown in 69 (12.8%), 293 (54.3%), 160 (29.7%) and 17 (3.2%) cases, respectively. The number of patients with sampled LN were higher if LN were identified by both the pathologist and the surgeon (n = 231, 42.8%) (p = < .001). At least one invaded LN (LN+) was found in 66 patients (12.2%), more than half being found among patients having LN sampled by both pathologist and surgeon (p < .001). The mean number of identified LN was six if no LN+ was detected on final histological analysis, while it was 11 in case of LN+ (p < .001).
Conclusions
The aim of sampling more than six LN is achievable, but only with the active collaboration of both surgeons and pathologists.</description><identifier>ISSN: 1545-5009</identifier><identifier>EISSN: 1545-5017</identifier><identifier>DOI: 10.1002/pbc.30107</identifier><identifier>PMID: 36453594</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adolescent ; Child ; Child, Preschool ; Clinical Trials as Topic ; Female ; Goals ; Hematology ; Humans ; Infant ; Infant, Newborn ; Kidney Neoplasms - pathology ; Kidney Neoplasms - surgery ; Lymph nodes ; Lymph Nodes - pathology ; Lymph Nodes - surgery ; Lymphatic system ; Male ; Metastases ; Neoplasm Staging ; Nephrectomy ; Oncology ; overall survival ; Pathology ; Pediatrics ; recurrence ; Retrospective Studies ; Surgeons ; Tumors ; Wilms Tumor - pathology ; Wilms Tumor - surgery ; Wilms tumour</subject><ispartof>Pediatric blood & cancer, 2023-03, Vol.70 (3), p.e30107-n/a</ispartof><rights>2022 Wiley Periodicals LLC.</rights><rights>2023 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3537-cf308f185b3fde871b60623d9b1cfe65b46e131db6f630c311aafdbcdb46f5e3</citedby><cites>FETCH-LOGICAL-c3537-cf308f185b3fde871b60623d9b1cfe65b46e131db6f630c311aafdbcdb46f5e3</cites><orcidid>0000-0002-1113-2792 ; 0000-0001-5596-9570</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpbc.30107$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpbc.30107$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36453594$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Irtan, Sabine</creatorcontrib><creatorcontrib>Coulomb‐Lhermine, Aurore</creatorcontrib><creatorcontrib>Lanz, Camille</creatorcontrib><creatorcontrib>Tabone, Marie‐Dominique</creatorcontrib><creatorcontrib>Pasqualini, Claudia</creatorcontrib><creatorcontrib>Dumont, Benoit</creatorcontrib><creatorcontrib>Thebaud, Estelle</creatorcontrib><creatorcontrib>Guellec, Isabelle</creatorcontrib><creatorcontrib>Verschuur, Arnauld</creatorcontrib><title>Number of lymph nodes sampled in SFCE/SIOP 2001 patients with Wilms tumour: Is the goal of more than six achievable?</title><title>Pediatric blood & cancer</title><addtitle>Pediatr Blood Cancer</addtitle><description>Aim
The number of lymph nodes (LN) that should be sampled during nephrectomy for Wilms tumour (WT) remains controversial but of utmost importance for staging purposes. The aim of this French national retrospective study of patients enrolled in SIOPWT2001 trial was to analyse the number of LN sampled according to their site and to determine if the number of six asked by the International Society of Paediatric Oncology ‐ Renal Tumour Study Group (SIOP‐RTSG) UMBRELLA protocol is achievable.
Methods
We reviewed the data collected on central pathology review forms from 2002 to 2014 for only unilateral WT. LN were divided whether they were clearly identified by surgeons at nephrectomy or only found by pathologists on the nephrectomy specimen.
Results
A total of 539 patients (240 male/299 female) were included (458 localized/81 metastatic). Median age at surgery was 41.3 months [0–189]. The number of LN sampled was 0, 1–6, ≥7 and unknown in 69 (12.8%), 293 (54.3%), 160 (29.7%) and 17 (3.2%) cases, respectively. The number of patients with sampled LN were higher if LN were identified by both the pathologist and the surgeon (n = 231, 42.8%) (p = < .001). At least one invaded LN (LN+) was found in 66 patients (12.2%), more than half being found among patients having LN sampled by both pathologist and surgeon (p < .001). The mean number of identified LN was six if no LN+ was detected on final histological analysis, while it was 11 in case of LN+ (p < .001).
Conclusions
The aim of sampling more than six LN is achievable, but only with the active collaboration of both surgeons and pathologists.</description><subject>Adolescent</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Clinical Trials as Topic</subject><subject>Female</subject><subject>Goals</subject><subject>Hematology</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Kidney Neoplasms - pathology</subject><subject>Kidney Neoplasms - surgery</subject><subject>Lymph nodes</subject><subject>Lymph Nodes - pathology</subject><subject>Lymph Nodes - surgery</subject><subject>Lymphatic system</subject><subject>Male</subject><subject>Metastases</subject><subject>Neoplasm Staging</subject><subject>Nephrectomy</subject><subject>Oncology</subject><subject>overall survival</subject><subject>Pathology</subject><subject>Pediatrics</subject><subject>recurrence</subject><subject>Retrospective Studies</subject><subject>Surgeons</subject><subject>Tumors</subject><subject>Wilms Tumor - pathology</subject><subject>Wilms Tumor - surgery</subject><subject>Wilms tumour</subject><issn>1545-5009</issn><issn>1545-5017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10ctKxDAUBuAgiveFLyABN7oYJ2matHUjOngZEBUUXJYkPXEiSVub1nHe3uioC8FVDsnHT5IfoT1KjikhybhV-pgRSrIVtEl5ykec0Gz1dybFBtoK4SVSQXi-jjaYSDnjRbqJ-tvBK-hwY7Bb-HaG66aCgIP0rYMK2xo_XE4uxg_Tu3ucEEJxK3sLdR_w3PYz_GSdD7gffDN0J3gaxxng50a6z0DfdBA3ZI2DfcdSzyy8SeXgdAetGekC7H6v2-jx8uJxcj26ubuaTs5uRppxlo20YSQ3NOeKmQryjCpBRMKqQlFtQHCVCqCMVkoYwYhmlEppKqWreGA4sG10uIxtu-Z1gNCX3gYNzskamiGUSZamIqM8LyI9-ENf4ovqeLmoRJ4lSUHTqI6WSndNCB2Ysu2sl92ipKT8bKKMTZRfTUS7_504KA_Vr_z5-gjGSzC3Dhb_J5X355Nl5AfRWZCf</recordid><startdate>202303</startdate><enddate>202303</enddate><creator>Irtan, Sabine</creator><creator>Coulomb‐Lhermine, Aurore</creator><creator>Lanz, Camille</creator><creator>Tabone, Marie‐Dominique</creator><creator>Pasqualini, Claudia</creator><creator>Dumont, Benoit</creator><creator>Thebaud, Estelle</creator><creator>Guellec, Isabelle</creator><creator>Verschuur, Arnauld</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7TO</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1113-2792</orcidid><orcidid>https://orcid.org/0000-0001-5596-9570</orcidid></search><sort><creationdate>202303</creationdate><title>Number of lymph nodes sampled in SFCE/SIOP 2001 patients with Wilms tumour: Is the goal of more than six achievable?</title><author>Irtan, Sabine ; Coulomb‐Lhermine, Aurore ; Lanz, Camille ; Tabone, Marie‐Dominique ; Pasqualini, Claudia ; Dumont, Benoit ; Thebaud, Estelle ; Guellec, Isabelle ; Verschuur, Arnauld</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3537-cf308f185b3fde871b60623d9b1cfe65b46e131db6f630c311aafdbcdb46f5e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adolescent</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Clinical Trials as Topic</topic><topic>Female</topic><topic>Goals</topic><topic>Hematology</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Kidney Neoplasms - pathology</topic><topic>Kidney Neoplasms - surgery</topic><topic>Lymph nodes</topic><topic>Lymph Nodes - pathology</topic><topic>Lymph Nodes - surgery</topic><topic>Lymphatic system</topic><topic>Male</topic><topic>Metastases</topic><topic>Neoplasm Staging</topic><topic>Nephrectomy</topic><topic>Oncology</topic><topic>overall survival</topic><topic>Pathology</topic><topic>Pediatrics</topic><topic>recurrence</topic><topic>Retrospective Studies</topic><topic>Surgeons</topic><topic>Tumors</topic><topic>Wilms Tumor - pathology</topic><topic>Wilms Tumor - surgery</topic><topic>Wilms tumour</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Irtan, Sabine</creatorcontrib><creatorcontrib>Coulomb‐Lhermine, Aurore</creatorcontrib><creatorcontrib>Lanz, Camille</creatorcontrib><creatorcontrib>Tabone, Marie‐Dominique</creatorcontrib><creatorcontrib>Pasqualini, Claudia</creatorcontrib><creatorcontrib>Dumont, Benoit</creatorcontrib><creatorcontrib>Thebaud, Estelle</creatorcontrib><creatorcontrib>Guellec, Isabelle</creatorcontrib><creatorcontrib>Verschuur, Arnauld</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric blood & cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Irtan, Sabine</au><au>Coulomb‐Lhermine, Aurore</au><au>Lanz, Camille</au><au>Tabone, Marie‐Dominique</au><au>Pasqualini, Claudia</au><au>Dumont, Benoit</au><au>Thebaud, Estelle</au><au>Guellec, Isabelle</au><au>Verschuur, Arnauld</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Number of lymph nodes sampled in SFCE/SIOP 2001 patients with Wilms tumour: Is the goal of more than six achievable?</atitle><jtitle>Pediatric blood & cancer</jtitle><addtitle>Pediatr Blood Cancer</addtitle><date>2023-03</date><risdate>2023</risdate><volume>70</volume><issue>3</issue><spage>e30107</spage><epage>n/a</epage><pages>e30107-n/a</pages><issn>1545-5009</issn><eissn>1545-5017</eissn><abstract>Aim
The number of lymph nodes (LN) that should be sampled during nephrectomy for Wilms tumour (WT) remains controversial but of utmost importance for staging purposes. The aim of this French national retrospective study of patients enrolled in SIOPWT2001 trial was to analyse the number of LN sampled according to their site and to determine if the number of six asked by the International Society of Paediatric Oncology ‐ Renal Tumour Study Group (SIOP‐RTSG) UMBRELLA protocol is achievable.
Methods
We reviewed the data collected on central pathology review forms from 2002 to 2014 for only unilateral WT. LN were divided whether they were clearly identified by surgeons at nephrectomy or only found by pathologists on the nephrectomy specimen.
Results
A total of 539 patients (240 male/299 female) were included (458 localized/81 metastatic). Median age at surgery was 41.3 months [0–189]. The number of LN sampled was 0, 1–6, ≥7 and unknown in 69 (12.8%), 293 (54.3%), 160 (29.7%) and 17 (3.2%) cases, respectively. The number of patients with sampled LN were higher if LN were identified by both the pathologist and the surgeon (n = 231, 42.8%) (p = < .001). At least one invaded LN (LN+) was found in 66 patients (12.2%), more than half being found among patients having LN sampled by both pathologist and surgeon (p < .001). The mean number of identified LN was six if no LN+ was detected on final histological analysis, while it was 11 in case of LN+ (p < .001).
Conclusions
The aim of sampling more than six LN is achievable, but only with the active collaboration of both surgeons and pathologists.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>36453594</pmid><doi>10.1002/pbc.30107</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-1113-2792</orcidid><orcidid>https://orcid.org/0000-0001-5596-9570</orcidid></addata></record> |
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| subjects | Adolescent Child Child, Preschool Clinical Trials as Topic Female Goals Hematology Humans Infant Infant, Newborn Kidney Neoplasms - pathology Kidney Neoplasms - surgery Lymph nodes Lymph Nodes - pathology Lymph Nodes - surgery Lymphatic system Male Metastases Neoplasm Staging Nephrectomy Oncology overall survival Pathology Pediatrics recurrence Retrospective Studies Surgeons Tumors Wilms Tumor - pathology Wilms Tumor - surgery Wilms tumour |
| title | Number of lymph nodes sampled in SFCE/SIOP 2001 patients with Wilms tumour: Is the goal of more than six achievable? |
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