Cathepsin G-Induced Cell Aggregation of Breast Cancer MCF-7 Decreases Doxorubicin Sensitivity in a Hypoxia-Inducible Factor-Independent Mechanism

Solid tumors habitually harbor regions with insufficient oxygen away from vasculature. Hypoxia is an important factor that confers malignant phenotypes like chemoresistance to tumor cells. We have demonstrated that cathepsin G (CG) stimulates cell aggregation in breast cancer MCF-7 cells by activati...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2022/12/01, Vol.45(12), pp.1772-1783
Hauptverfasser:	Morimoto-Kamata, Riyo, Matsuki, Shun, Ohkura, Naoki, Yui, Satoru
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast cancer Cathepsin G Cell aggregation Chemoresistance Cytotoxicity Doxorubicin Electrophoretic mobility Hypoxia Hypoxia-inducible factor 1a Insulin Insulin-like growth factor I neutrophil protease P-Glycoprotein Phenotypes siRNA Solid tumors Tumor cells
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