Hepatoprotective effect of methanolic extract of Iris florentina L. on paracetamol-induced liver toxicity in rats
Despite of plethora of research on hepatoprotective potential of medicinal plants, there is still need to discover potential plants with hepatoprotective activity. Iris florentina L. is a medicinal plant with traditional claims but ignored investigation regarding its hepatoprotective effects. The cu...
Gespeichert in:
| Veröffentlicht in: | Pakistan journal of pharmaceutical sciences 2022-09, Vol.35 (5), p.1399-1405 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1405 |
|---|---|
| container_issue | 5 |
| container_start_page | 1399 |
| container_title | Pakistan journal of pharmaceutical sciences |
| container_volume | 35 |
| creator | Nawaz, Muhammad Asif Aleem, Ambreen Hussain, Syed Adil Manzoor, Majid Latif, Samia Sarwar, Muhammad Irfan Khan, Mohsin Talib, Sheeza |
| description | Despite of plethora of research on hepatoprotective potential of medicinal plants, there is still need to discover potential plants with hepatoprotective activity. Iris florentina L. is a medicinal plant with traditional claims but ignored investigation regarding its hepatoprotective effects. The current study is aimed to investigate the hepatoprotective potential of I.florentina L. methanolic extract on paracetamol (PCM)-induced liver injury. The phytochemical and HPLC screening was done which showed the presence of potential constituents including flavonoids and phenols. For investigating the hepatoprotective effect of I.florentina L. methanolic extract, rats were given five different treatments for seven consecutive days. The normal control (group 1) was administered with normal saline, group 2 (Diseased) received paracetamol and group 3 (Standard) was given silymarin as reference drug. In group 4 and 5 (Treated), I.florentina L. methanolic extract (250 and 500 mg/kg) were administered. Different serum biomarkers and histopathological studies were performed to assess the recovery caused by PCM in comparison to diseased group. The treatment of I.florentina methanolic extract significantly improve the serum biomarkers and restored the hepatic injury towards normal, indicating the hepatoprotective potential. Thus, we can conclude that I. florentina have significantly reversed the damage caused by paracetamol in hepatotoxic rat model due to their potential phytochemical constituents. Keywords: Liver, hepatoprotective, Iris florentina, flavonoids, phenolic compounds, paracetamol. |
| doi_str_mv | 10.36721/PJPS.2022.35.5.REG.1399-1405.1 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2744667743</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A725085923</galeid><sourcerecordid>A725085923</sourcerecordid><originalsourceid>FETCH-LOGICAL-g255t-901dd7c6ad43a19bc1a9e8189111b1e46abb56ca6a046c554cceae4b29f2ce853</originalsourceid><addsrcrecordid>eNptj0tPwzAQhHMAifL4D5Y4wCXG69hOfawqnqoE4iFxizbOphildklcBP-eVOXAAe1hVzPfjjRZdgaCF6aUcPFw9_DEpZCSF5pr_nh5zaGwNgclNIe9bAICIDcCXg-yw2F4F8Ioa-0k-7ihNaa47mMil_wnMWrb8WKxZStKbxhi5x2jr9TjTr3t_cDaLvYUkg_IFpzFwNY4-pRwFbvch2bjqGHdGNezFL-88-mb-cB6TMNxtt9iN9DJ7z7KXq4un-c3-eL--nY-W-RLqXXKrYCmKZ3BRhUItnaAlqYwtQBQAymDda2NQ4NCGae1co6QVC1tKx1NdXGUne9yx24fGxpStfKDo67DQHEzVLJUypiyVMWInu7QJXZU-dDGbdstXs1KqcVUW7ml-D_UOA2tvIuBWj_qfx5-AF4PfZc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2744667743</pqid></control><display><type>article</type><title>Hepatoprotective effect of methanolic extract of Iris florentina L. on paracetamol-induced liver toxicity in rats</title><source>EZB-FREE-00999 freely available EZB journals</source><creator>Nawaz, Muhammad Asif ; Aleem, Ambreen ; Hussain, Syed Adil ; Manzoor, Majid ; Latif, Samia ; Sarwar, Muhammad Irfan ; Khan, Mohsin ; Talib, Sheeza</creator><creatorcontrib>Nawaz, Muhammad Asif ; Aleem, Ambreen ; Hussain, Syed Adil ; Manzoor, Majid ; Latif, Samia ; Sarwar, Muhammad Irfan ; Khan, Mohsin ; Talib, Sheeza</creatorcontrib><description>Despite of plethora of research on hepatoprotective potential of medicinal plants, there is still need to discover potential plants with hepatoprotective activity. Iris florentina L. is a medicinal plant with traditional claims but ignored investigation regarding its hepatoprotective effects. The current study is aimed to investigate the hepatoprotective potential of I.florentina L. methanolic extract on paracetamol (PCM)-induced liver injury. The phytochemical and HPLC screening was done which showed the presence of potential constituents including flavonoids and phenols. For investigating the hepatoprotective effect of I.florentina L. methanolic extract, rats were given five different treatments for seven consecutive days. The normal control (group 1) was administered with normal saline, group 2 (Diseased) received paracetamol and group 3 (Standard) was given silymarin as reference drug. In group 4 and 5 (Treated), I.florentina L. methanolic extract (250 and 500 mg/kg) were administered. Different serum biomarkers and histopathological studies were performed to assess the recovery caused by PCM in comparison to diseased group. The treatment of I.florentina methanolic extract significantly improve the serum biomarkers and restored the hepatic injury towards normal, indicating the hepatoprotective potential. Thus, we can conclude that I. florentina have significantly reversed the damage caused by paracetamol in hepatotoxic rat model due to their potential phytochemical constituents. Keywords: Liver, hepatoprotective, Iris florentina, flavonoids, phenolic compounds, paracetamol.</description><identifier>ISSN: 1011-601X</identifier><identifier>DOI: 10.36721/PJPS.2022.35.5.REG.1399-1405.1</identifier><language>eng</language><publisher>Pakistan Journal of Pharmaceutical Sciences</publisher><subject>Acetaminophen ; Care and treatment ; Chemical properties ; Complications and side effects ; Iris (Plant) ; Liver diseases ; Medicinal plants ; Medicine, Botanic ; Medicine, Herbal ; Pharmacology, Experimental</subject><ispartof>Pakistan journal of pharmaceutical sciences, 2022-09, Vol.35 (5), p.1399-1405</ispartof><rights>COPYRIGHT 2022 Pakistan Journal of Pharmaceutical Sciences</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Nawaz, Muhammad Asif</creatorcontrib><creatorcontrib>Aleem, Ambreen</creatorcontrib><creatorcontrib>Hussain, Syed Adil</creatorcontrib><creatorcontrib>Manzoor, Majid</creatorcontrib><creatorcontrib>Latif, Samia</creatorcontrib><creatorcontrib>Sarwar, Muhammad Irfan</creatorcontrib><creatorcontrib>Khan, Mohsin</creatorcontrib><creatorcontrib>Talib, Sheeza</creatorcontrib><title>Hepatoprotective effect of methanolic extract of Iris florentina L. on paracetamol-induced liver toxicity in rats</title><title>Pakistan journal of pharmaceutical sciences</title><description>Despite of plethora of research on hepatoprotective potential of medicinal plants, there is still need to discover potential plants with hepatoprotective activity. Iris florentina L. is a medicinal plant with traditional claims but ignored investigation regarding its hepatoprotective effects. The current study is aimed to investigate the hepatoprotective potential of I.florentina L. methanolic extract on paracetamol (PCM)-induced liver injury. The phytochemical and HPLC screening was done which showed the presence of potential constituents including flavonoids and phenols. For investigating the hepatoprotective effect of I.florentina L. methanolic extract, rats were given five different treatments for seven consecutive days. The normal control (group 1) was administered with normal saline, group 2 (Diseased) received paracetamol and group 3 (Standard) was given silymarin as reference drug. In group 4 and 5 (Treated), I.florentina L. methanolic extract (250 and 500 mg/kg) were administered. Different serum biomarkers and histopathological studies were performed to assess the recovery caused by PCM in comparison to diseased group. The treatment of I.florentina methanolic extract significantly improve the serum biomarkers and restored the hepatic injury towards normal, indicating the hepatoprotective potential. Thus, we can conclude that I. florentina have significantly reversed the damage caused by paracetamol in hepatotoxic rat model due to their potential phytochemical constituents. Keywords: Liver, hepatoprotective, Iris florentina, flavonoids, phenolic compounds, paracetamol.</description><subject>Acetaminophen</subject><subject>Care and treatment</subject><subject>Chemical properties</subject><subject>Complications and side effects</subject><subject>Iris (Plant)</subject><subject>Liver diseases</subject><subject>Medicinal plants</subject><subject>Medicine, Botanic</subject><subject>Medicine, Herbal</subject><subject>Pharmacology, Experimental</subject><issn>1011-601X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNptj0tPwzAQhHMAifL4D5Y4wCXG69hOfawqnqoE4iFxizbOphildklcBP-eVOXAAe1hVzPfjjRZdgaCF6aUcPFw9_DEpZCSF5pr_nh5zaGwNgclNIe9bAICIDcCXg-yw2F4F8Ioa-0k-7ihNaa47mMil_wnMWrb8WKxZStKbxhi5x2jr9TjTr3t_cDaLvYUkg_IFpzFwNY4-pRwFbvch2bjqGHdGNezFL-88-mb-cB6TMNxtt9iN9DJ7z7KXq4un-c3-eL--nY-W-RLqXXKrYCmKZ3BRhUItnaAlqYwtQBQAymDda2NQ4NCGae1co6QVC1tKx1NdXGUne9yx24fGxpStfKDo67DQHEzVLJUypiyVMWInu7QJXZU-dDGbdstXs1KqcVUW7ml-D_UOA2tvIuBWj_qfx5-AF4PfZc</recordid><startdate>20220901</startdate><enddate>20220901</enddate><creator>Nawaz, Muhammad Asif</creator><creator>Aleem, Ambreen</creator><creator>Hussain, Syed Adil</creator><creator>Manzoor, Majid</creator><creator>Latif, Samia</creator><creator>Sarwar, Muhammad Irfan</creator><creator>Khan, Mohsin</creator><creator>Talib, Sheeza</creator><general>Pakistan Journal of Pharmaceutical Sciences</general><scope>7X8</scope></search><sort><creationdate>20220901</creationdate><title>Hepatoprotective effect of methanolic extract of Iris florentina L. on paracetamol-induced liver toxicity in rats</title><author>Nawaz, Muhammad Asif ; Aleem, Ambreen ; Hussain, Syed Adil ; Manzoor, Majid ; Latif, Samia ; Sarwar, Muhammad Irfan ; Khan, Mohsin ; Talib, Sheeza</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g255t-901dd7c6ad43a19bc1a9e8189111b1e46abb56ca6a046c554cceae4b29f2ce853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Acetaminophen</topic><topic>Care and treatment</topic><topic>Chemical properties</topic><topic>Complications and side effects</topic><topic>Iris (Plant)</topic><topic>Liver diseases</topic><topic>Medicinal plants</topic><topic>Medicine, Botanic</topic><topic>Medicine, Herbal</topic><topic>Pharmacology, Experimental</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nawaz, Muhammad Asif</creatorcontrib><creatorcontrib>Aleem, Ambreen</creatorcontrib><creatorcontrib>Hussain, Syed Adil</creatorcontrib><creatorcontrib>Manzoor, Majid</creatorcontrib><creatorcontrib>Latif, Samia</creatorcontrib><creatorcontrib>Sarwar, Muhammad Irfan</creatorcontrib><creatorcontrib>Khan, Mohsin</creatorcontrib><creatorcontrib>Talib, Sheeza</creatorcontrib><collection>MEDLINE - Academic</collection><jtitle>Pakistan journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nawaz, Muhammad Asif</au><au>Aleem, Ambreen</au><au>Hussain, Syed Adil</au><au>Manzoor, Majid</au><au>Latif, Samia</au><au>Sarwar, Muhammad Irfan</au><au>Khan, Mohsin</au><au>Talib, Sheeza</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatoprotective effect of methanolic extract of Iris florentina L. on paracetamol-induced liver toxicity in rats</atitle><jtitle>Pakistan journal of pharmaceutical sciences</jtitle><date>2022-09-01</date><risdate>2022</risdate><volume>35</volume><issue>5</issue><spage>1399</spage><epage>1405</epage><pages>1399-1405</pages><issn>1011-601X</issn><abstract>Despite of plethora of research on hepatoprotective potential of medicinal plants, there is still need to discover potential plants with hepatoprotective activity. Iris florentina L. is a medicinal plant with traditional claims but ignored investigation regarding its hepatoprotective effects. The current study is aimed to investigate the hepatoprotective potential of I.florentina L. methanolic extract on paracetamol (PCM)-induced liver injury. The phytochemical and HPLC screening was done which showed the presence of potential constituents including flavonoids and phenols. For investigating the hepatoprotective effect of I.florentina L. methanolic extract, rats were given five different treatments for seven consecutive days. The normal control (group 1) was administered with normal saline, group 2 (Diseased) received paracetamol and group 3 (Standard) was given silymarin as reference drug. In group 4 and 5 (Treated), I.florentina L. methanolic extract (250 and 500 mg/kg) were administered. Different serum biomarkers and histopathological studies were performed to assess the recovery caused by PCM in comparison to diseased group. The treatment of I.florentina methanolic extract significantly improve the serum biomarkers and restored the hepatic injury towards normal, indicating the hepatoprotective potential. Thus, we can conclude that I. florentina have significantly reversed the damage caused by paracetamol in hepatotoxic rat model due to their potential phytochemical constituents. Keywords: Liver, hepatoprotective, Iris florentina, flavonoids, phenolic compounds, paracetamol.</abstract><pub>Pakistan Journal of Pharmaceutical Sciences</pub><doi>10.36721/PJPS.2022.35.5.REG.1399-1405.1</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1011-601X |
| ispartof | Pakistan journal of pharmaceutical sciences, 2022-09, Vol.35 (5), p.1399-1405 |
| issn | 1011-601X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2744667743 |
| source | EZB-FREE-00999 freely available EZB journals |
| subjects | Acetaminophen Care and treatment Chemical properties Complications and side effects Iris (Plant) Liver diseases Medicinal plants Medicine, Botanic Medicine, Herbal Pharmacology, Experimental |
| title | Hepatoprotective effect of methanolic extract of Iris florentina L. on paracetamol-induced liver toxicity in rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T06%3A11%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Hepatoprotective%20effect%20of%20methanolic%20extract%20of%20Iris%20florentina%20L.%20on%20paracetamol-induced%20liver%20toxicity%20in%20rats&rft.jtitle=Pakistan%20journal%20of%20pharmaceutical%20sciences&rft.au=Nawaz,%20Muhammad%20Asif&rft.date=2022-09-01&rft.volume=35&rft.issue=5&rft.spage=1399&rft.epage=1405&rft.pages=1399-1405&rft.issn=1011-601X&rft_id=info:doi/10.36721/PJPS.2022.35.5.REG.1399-1405.1&rft_dat=%3Cgale_proqu%3EA725085923%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2744667743&rft_id=info:pmid/&rft_galeid=A725085923&rfr_iscdi=true |