Blood and tissue compatibility of modified polyester: Thrombosis, inflammation, and healing
Poly(ethylene terephthalate) (PET) has been reported in literature to be moderately inflammatory and thrombogenic. To moderate the inflammatory response, PET fabric was surface modified by either Fluoropassiv™ fluoropolymer (FC), or an RGD‐containing peptide (RGD). Samples were subsequently autoclav...
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| Veröffentlicht in: | Journal of biomedical materials research 1998-01, Vol.39 (1), p.130-140 |
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| creator | Chinn, Joseph A. Sauter, Joseph A. Phillips Jr, Richard E. Kao, Weiyuan J. Anderson, James M. Hanson, Stephen R. Ashton, Timothy R. |
| description | Poly(ethylene terephthalate) (PET) has been reported in literature to be moderately inflammatory and thrombogenic. To moderate the inflammatory response, PET fabric was surface modified by either Fluoropassiv™ fluoropolymer (FC), or an RGD‐containing peptide (RGD). Samples were subsequently autoclave sterilized and implanted subcutaneously in Sprague Dawley rats for 2 to 4 weeks. Retrieved samples were evaluated histopathologically for indications of material toxicity and healing. Minimal acute or chronic inflammation was associated with the fabrics after 2 and 4 week implant duration. However, fibroblast proliferation into FC modified fabric (PET/FC) was less than that into unmodified (PET) and RGD modified fabric (PET/RGD) after 4 weeks, suggesting that FC modification of PET may inhibit excessive tissue growth. Additional samples of modified and unmodified fabrics were placed in stainless steel mesh cages, which were then implanted subcutaneously for 4 weeks. Cellular exudate was extracted weekly and cell concentrations within the exudate measured. Total leukocyte count (TLC) (reflective of local inflammation) at 1 week for PET/RGD was greater than that for PET/FC and PET. TLCs after 4 week implant decreased for all sample groups. In a separate experiment, PET vascular grafts surface modified by either FC or RGD were contacted 1h with blood using the baboon arteriovenous (AV) shunt model of thrombosis in both the presence and absence of heparin. Accumulation of 111In labeled platelets (reflective of thrombus accumulation) upon grafts was less in the presence of heparin (effect significant at p = 1.2 × 10−6, two‐way ANOVA). Accumulation (in the presence of heparin) upon PET/RGD was less (p = 0.19), and upon PET/FC significantly less (p = 0.016) than that upon the unmodified PET control, suggesting that FC modification of PET may inhibit thrombus accumulation. © 1998 John Wiley & Sons, Inc. J Biomed Mater Res, 39, 130–140, 1998. |
| doi_str_mv | 10.1002/(SICI)1097-4636(19980101)39:1<130::AID-JBM15>3.0.CO;2-J |
| format | Article |
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To moderate the inflammatory response, PET fabric was surface modified by either Fluoropassiv™ fluoropolymer (FC), or an RGD‐containing peptide (RGD). Samples were subsequently autoclave sterilized and implanted subcutaneously in Sprague Dawley rats for 2 to 4 weeks. Retrieved samples were evaluated histopathologically for indications of material toxicity and healing. Minimal acute or chronic inflammation was associated with the fabrics after 2 and 4 week implant duration. However, fibroblast proliferation into FC modified fabric (PET/FC) was less than that into unmodified (PET) and RGD modified fabric (PET/RGD) after 4 weeks, suggesting that FC modification of PET may inhibit excessive tissue growth. Additional samples of modified and unmodified fabrics were placed in stainless steel mesh cages, which were then implanted subcutaneously for 4 weeks. Cellular exudate was extracted weekly and cell concentrations within the exudate measured. Total leukocyte count (TLC) (reflective of local inflammation) at 1 week for PET/RGD was greater than that for PET/FC and PET. TLCs after 4 week implant decreased for all sample groups. In a separate experiment, PET vascular grafts surface modified by either FC or RGD were contacted 1h with blood using the baboon arteriovenous (AV) shunt model of thrombosis in both the presence and absence of heparin. Accumulation of 111In labeled platelets (reflective of thrombus accumulation) upon grafts was less in the presence of heparin (effect significant at p = 1.2 × 10−6, two‐way ANOVA). Accumulation (in the presence of heparin) upon PET/RGD was less (p = 0.19), and upon PET/FC significantly less (p = 0.016) than that upon the unmodified PET control, suggesting that FC modification of PET may inhibit thrombus accumulation. © 1998 John Wiley & Sons, Inc. J Biomed Mater Res, 39, 130–140, 1998.</description><identifier>ISSN: 0021-9304</identifier><identifier>EISSN: 1097-4636</identifier><identifier>DOI: 10.1002/(SICI)1097-4636(19980101)39:1<130::AID-JBM15>3.0.CO;2-J</identifier><identifier>PMID: 9429104</identifier><identifier>CODEN: JBMRBG</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Animals ; Biocompatibility ; Biocompatible Materials - adverse effects ; Biological and medical sciences ; Bioprosthesis ; Blood ; Cells ; Fabrics ; Fluorine containing polymers ; Fluoropassivated ; Grafts ; healing ; Inflammation ; Medical sciences ; Papio ; Polyesters - adverse effects ; Polyethylene terephthalates ; Rats ; Surface treatment ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Thrombosis ; Tissue ; Toxicity ; vascular graft ; Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels</subject><ispartof>Journal of biomedical materials research, 1998-01, Vol.39 (1), p.130-140</ispartof><rights>Copyright © 1998 John Wiley & Sons, Inc.</rights><rights>1998 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4965-20f6d625a99d9bb41f5f86c9cdbaf1429e6ff3652ab80c73f3f57f6fab246c1f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F%28SICI%291097-4636%2819980101%2939%3A1%3C130%3A%3AAID-JBM15%3E3.0.CO%3B2-J$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F%28SICI%291097-4636%2819980101%2939%3A1%3C130%3A%3AAID-JBM15%3E3.0.CO%3B2-J$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2091728$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9429104$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chinn, Joseph A.</creatorcontrib><creatorcontrib>Sauter, Joseph A.</creatorcontrib><creatorcontrib>Phillips Jr, Richard E.</creatorcontrib><creatorcontrib>Kao, Weiyuan J.</creatorcontrib><creatorcontrib>Anderson, James M.</creatorcontrib><creatorcontrib>Hanson, Stephen R.</creatorcontrib><creatorcontrib>Ashton, Timothy R.</creatorcontrib><title>Blood and tissue compatibility of modified polyester: Thrombosis, inflammation, and healing</title><title>Journal of biomedical materials research</title><addtitle>J. Biomed. Mater. Res</addtitle><description>Poly(ethylene terephthalate) (PET) has been reported in literature to be moderately inflammatory and thrombogenic. To moderate the inflammatory response, PET fabric was surface modified by either Fluoropassiv™ fluoropolymer (FC), or an RGD‐containing peptide (RGD). Samples were subsequently autoclave sterilized and implanted subcutaneously in Sprague Dawley rats for 2 to 4 weeks. Retrieved samples were evaluated histopathologically for indications of material toxicity and healing. Minimal acute or chronic inflammation was associated with the fabrics after 2 and 4 week implant duration. However, fibroblast proliferation into FC modified fabric (PET/FC) was less than that into unmodified (PET) and RGD modified fabric (PET/RGD) after 4 weeks, suggesting that FC modification of PET may inhibit excessive tissue growth. Additional samples of modified and unmodified fabrics were placed in stainless steel mesh cages, which were then implanted subcutaneously for 4 weeks. Cellular exudate was extracted weekly and cell concentrations within the exudate measured. Total leukocyte count (TLC) (reflective of local inflammation) at 1 week for PET/RGD was greater than that for PET/FC and PET. TLCs after 4 week implant decreased for all sample groups. In a separate experiment, PET vascular grafts surface modified by either FC or RGD were contacted 1h with blood using the baboon arteriovenous (AV) shunt model of thrombosis in both the presence and absence of heparin. Accumulation of 111In labeled platelets (reflective of thrombus accumulation) upon grafts was less in the presence of heparin (effect significant at p = 1.2 × 10−6, two‐way ANOVA). Accumulation (in the presence of heparin) upon PET/RGD was less (p = 0.19), and upon PET/FC significantly less (p = 0.016) than that upon the unmodified PET control, suggesting that FC modification of PET may inhibit thrombus accumulation. © 1998 John Wiley & Sons, Inc. J Biomed Mater Res, 39, 130–140, 1998.</description><subject>Animals</subject><subject>Biocompatibility</subject><subject>Biocompatible Materials - adverse effects</subject><subject>Biological and medical sciences</subject><subject>Bioprosthesis</subject><subject>Blood</subject><subject>Cells</subject><subject>Fabrics</subject><subject>Fluorine containing polymers</subject><subject>Fluoropassivated</subject><subject>Grafts</subject><subject>healing</subject><subject>Inflammation</subject><subject>Medical sciences</subject><subject>Papio</subject><subject>Polyesters - adverse effects</subject><subject>Polyethylene terephthalates</subject><subject>Rats</subject><subject>Surface treatment</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Thrombosis</subject><subject>Tissue</subject><subject>Toxicity</subject><subject>vascular graft</subject><subject>Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels</subject><issn>0021-9304</issn><issn>1097-4636</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkdFu0zAUhiMEGmXwCEi5QGiTluJjJ05dEGgLrGs11guGhsTFkePYzJDEJW4FfXucpfQGpF1Z8vnPp1_ni6J3QMZACH119GlezI-BiDxJOeNHIMSEAIFjJqbwBhiZTk_n75PF2UfI3rIxGRfL1zRZPIhG-52H0SiQIBGMpI-jJ95_J4QIweAgOhApFUDSUfT1rHauimVbxWvr_UbHyjUrubalre16GzsTN66yxuoqXrl6q_1ad9P4-rZzTem89SexbU0tmybsuPbkjnSrZW3bb0-jR0bWXj_bvYfR5_MP18VFcrmczYvTy0SlgmcJJYZXnGZSiEqUZQomMxOuhKpKaSAU1dwYxjMqywlROTPMZLnhRpY05QoMO4xeDtxV535uQkNsrFe6rmWr3cYjzdOUpIzfHwQazpz3wZshqDrnfacNrjrbyG6LQLD3g9j7wf7W2N8a__pBJhAw-EEMfvDODzIkWCyR4iKQn-8qbMpGV3vuTkiYv9jNpVeyNp1slfX7GCUCcjoJsS9D7Jet9fafdveW-1-34SOgkwFtg-rfe7TsfiDPWZ7hzdUMF-QcKMyu8IL9AX2qx5s</recordid><startdate>199801</startdate><enddate>199801</enddate><creator>Chinn, Joseph A.</creator><creator>Sauter, Joseph A.</creator><creator>Phillips Jr, Richard E.</creator><creator>Kao, Weiyuan J.</creator><creator>Anderson, James M.</creator><creator>Hanson, Stephen R.</creator><creator>Ashton, Timothy R.</creator><general>John Wiley & Sons, Inc</general><general>John Wiley & Sons</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>JG9</scope></search><sort><creationdate>199801</creationdate><title>Blood and tissue compatibility of modified polyester: Thrombosis, inflammation, and healing</title><author>Chinn, Joseph A. ; Sauter, Joseph A. ; Phillips Jr, Richard E. ; Kao, Weiyuan J. ; Anderson, James M. ; Hanson, Stephen R. ; Ashton, Timothy R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4965-20f6d625a99d9bb41f5f86c9cdbaf1429e6ff3652ab80c73f3f57f6fab246c1f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Biocompatibility</topic><topic>Biocompatible Materials - adverse effects</topic><topic>Biological and medical sciences</topic><topic>Bioprosthesis</topic><topic>Blood</topic><topic>Cells</topic><topic>Fabrics</topic><topic>Fluorine containing polymers</topic><topic>Fluoropassivated</topic><topic>Grafts</topic><topic>healing</topic><topic>Inflammation</topic><topic>Medical sciences</topic><topic>Papio</topic><topic>Polyesters - adverse effects</topic><topic>Polyethylene terephthalates</topic><topic>Rats</topic><topic>Surface treatment</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Thrombosis</topic><topic>Tissue</topic><topic>Toxicity</topic><topic>vascular graft</topic><topic>Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels</topic><toplevel>online_resources</toplevel><creatorcontrib>Chinn, Joseph A.</creatorcontrib><creatorcontrib>Sauter, Joseph A.</creatorcontrib><creatorcontrib>Phillips Jr, Richard E.</creatorcontrib><creatorcontrib>Kao, Weiyuan J.</creatorcontrib><creatorcontrib>Anderson, James M.</creatorcontrib><creatorcontrib>Hanson, Stephen R.</creatorcontrib><creatorcontrib>Ashton, Timothy R.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Journal of biomedical materials research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chinn, Joseph A.</au><au>Sauter, Joseph A.</au><au>Phillips Jr, Richard E.</au><au>Kao, Weiyuan J.</au><au>Anderson, James M.</au><au>Hanson, Stephen R.</au><au>Ashton, Timothy R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blood and tissue compatibility of modified polyester: Thrombosis, inflammation, and healing</atitle><jtitle>Journal of biomedical materials research</jtitle><addtitle>J. Biomed. Mater. Res</addtitle><date>1998-01</date><risdate>1998</risdate><volume>39</volume><issue>1</issue><spage>130</spage><epage>140</epage><pages>130-140</pages><issn>0021-9304</issn><eissn>1097-4636</eissn><coden>JBMRBG</coden><abstract>Poly(ethylene terephthalate) (PET) has been reported in literature to be moderately inflammatory and thrombogenic. To moderate the inflammatory response, PET fabric was surface modified by either Fluoropassiv™ fluoropolymer (FC), or an RGD‐containing peptide (RGD). Samples were subsequently autoclave sterilized and implanted subcutaneously in Sprague Dawley rats for 2 to 4 weeks. Retrieved samples were evaluated histopathologically for indications of material toxicity and healing. Minimal acute or chronic inflammation was associated with the fabrics after 2 and 4 week implant duration. However, fibroblast proliferation into FC modified fabric (PET/FC) was less than that into unmodified (PET) and RGD modified fabric (PET/RGD) after 4 weeks, suggesting that FC modification of PET may inhibit excessive tissue growth. Additional samples of modified and unmodified fabrics were placed in stainless steel mesh cages, which were then implanted subcutaneously for 4 weeks. Cellular exudate was extracted weekly and cell concentrations within the exudate measured. Total leukocyte count (TLC) (reflective of local inflammation) at 1 week for PET/RGD was greater than that for PET/FC and PET. TLCs after 4 week implant decreased for all sample groups. In a separate experiment, PET vascular grafts surface modified by either FC or RGD were contacted 1h with blood using the baboon arteriovenous (AV) shunt model of thrombosis in both the presence and absence of heparin. Accumulation of 111In labeled platelets (reflective of thrombus accumulation) upon grafts was less in the presence of heparin (effect significant at p = 1.2 × 10−6, two‐way ANOVA). Accumulation (in the presence of heparin) upon PET/RGD was less (p = 0.19), and upon PET/FC significantly less (p = 0.016) than that upon the unmodified PET control, suggesting that FC modification of PET may inhibit thrombus accumulation. © 1998 John Wiley & Sons, Inc. J Biomed Mater Res, 39, 130–140, 1998.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>9429104</pmid><doi>10.1002/(SICI)1097-4636(19980101)39:1<130::AID-JBM15>3.0.CO;2-J</doi><tpages>11</tpages></addata></record> |
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| subjects | Animals Biocompatibility Biocompatible Materials - adverse effects Biological and medical sciences Bioprosthesis Blood Cells Fabrics Fluorine containing polymers Fluoropassivated Grafts healing Inflammation Medical sciences Papio Polyesters - adverse effects Polyethylene terephthalates Rats Surface treatment Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Thrombosis Tissue Toxicity vascular graft Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels |
| title | Blood and tissue compatibility of modified polyester: Thrombosis, inflammation, and healing |
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