TAX1BP1 a novel player in antigen presentation

CD4$^+$ T lymphocytes play a major role in establishing and maintaining antiviral immunity. They are activated by anti- genic peptides derived from extracellular or newly synthesized (endogenous) proteins presented by the MHC-II molecules. Little is known about the mechanisms leading to endogenous M...

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Veröffentlicht in:	Autophagy 2023-07, Vol.19 (7), p.2153-2155
Hauptverfasser:	Sarango, Gabriela, Manoury, Bénédicte, Moris, Arnaud
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigen Presentation Autophagic Punctum Autophagy autophagy receptors calnexin Histocompatibility Antigens Class II HLA-DM immunopeptidome interactome invariant chain Life Sciences MHC T cells TAX1BP1
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container_end_page	2155
container_issue	7
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container_title	Autophagy
container_volume	19
creator	Sarango, Gabriela Manoury, Bénédicte Moris, Arnaud
description	CD4$^+$ T lymphocytes play a major role in establishing and maintaining antiviral immunity. They are activated by anti- genic peptides derived from extracellular or newly synthesized (endogenous) proteins presented by the MHC-II molecules. Little is known about the mechanisms leading to endogenous MHC-II-restricted antigen presentation. We recently revealed a novel function of the macroautophagy/autophagy receptor (AR), TAX1BP1, in the presentation of endogenous viral antigens to CD4$^+$ T cells. In this punctum, we will focus on MHC-II-restricted endogenous antigen presentation and the involvement of TAX1BP1 in the biology of MHC-II molecules.
doi_str_mv	10.1080/15548627.2022.2153570
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subjects	Antigen Presentation Autophagic Punctum Autophagy autophagy receptors calnexin Histocompatibility Antigens Class II HLA-DM immunopeptidome interactome invariant chain Life Sciences MHC T cells TAX1BP1
title	TAX1BP1 a novel player in antigen presentation
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