Bractoppin, a BRCA1 carboxy-terminal domain (BRCT) inhibitor, suppresses tumor progression in ovarian borderline tumor organoids

Borderline ovarian tumors are a special class of ovarian tumors between benign and malignant, which are not sensitive to traditional chemotherapy regimens, and the development of target drugs is limited due to the lack of cell lines. Tumor organoids can well preserve the genetic characteristics of t...

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Veröffentlicht in:	Biochemical and biophysical research communications 2023-01, Vol.638, p.76-83
Hauptverfasser:	Wan, Yicong, Zhang, Yashuang, Meng, Huangyang, Miao, Huixian, Jiang, Yi, Zhang, Lin, Cheng, Wenjun
Format:	Artikel
Sprache:	eng
Schlagworte:	Borderline ovarian tumors Bractoppin BRCA1 BRCA1 Protein - genetics BRCA1 Protein - metabolism BRCT Female Humans Organoid Organoids - metabolism Ovarian Neoplasms - drug therapy Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism
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