Altered Signatures of Plasma Inflammatory Proteins and Phonotypic Markers of NK Cells in Kidney Transplant Patients upon CMV Reactivation
Cytomegalovirus (CMV) reactivation remains a common opportunistic infection with a prominent role in immune reconstitution in organ transplant recipients. CMVs as important drivers of natural killer (NK) cell differentiation has been indicated to prompt several phenotypic and functional alteration i...
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| Veröffentlicht in: | Current microbiology 2023-01, Vol.80 (1), p.9-9, Article 9 |
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| creator | Soleimanian, Saeede Yaghobi, Ramin Karimi, Mohammad Hossein Geramizadeh, Bita Roozbeh, Jamshid |
| description | Cytomegalovirus (CMV) reactivation remains a common opportunistic infection with a prominent role in immune reconstitution in organ transplant recipients. CMVs as important drivers of natural killer (NK) cell differentiation has been indicated to prompt several phenotypic and functional alteration in these cells. We aimed to monitor the reconstitution of NK cells and change the signature of inflammatory proteins at the critical phase of CMV reactivation over six months after kidney transplantation. The present study indicated that CMV reactivation is associated with the development of IL-6, IL-10, and cytotoxic granules, including granzyme-B and granulysin, and the drop in the frequency of CD16 + NKG2A-CD57 + NK cell subset in kidney transplant recipients (KTRs) with reactivation versus non- reactivated ones. Our findings describe distinct immune signatures that emerged with CMV reactivation after kidney transplantation, which may be helpful in the timely management of CMV infection in KTRs. |
| doi_str_mv | 10.1007/s00284-022-03116-9 |
| format | Article |
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CMVs as important drivers of natural killer (NK) cell differentiation has been indicated to prompt several phenotypic and functional alteration in these cells. We aimed to monitor the reconstitution of NK cells and change the signature of inflammatory proteins at the critical phase of CMV reactivation over six months after kidney transplantation. The present study indicated that CMV reactivation is associated with the development of IL-6, IL-10, and cytotoxic granules, including granzyme-B and granulysin, and the drop in the frequency of CD16 + NKG2A-CD57 + NK cell subset in kidney transplant recipients (KTRs) with reactivation versus non- reactivated ones. Our findings describe distinct immune signatures that emerged with CMV reactivation after kidney transplantation, which may be helpful in the timely management of CMV infection in KTRs.</description><identifier>ISSN: 0343-8651</identifier><identifier>EISSN: 1432-0991</identifier><identifier>DOI: 10.1007/s00284-022-03116-9</identifier><identifier>PMID: 36445486</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Antibodies ; Biomarkers ; Biomedical and Life Sciences ; Biotechnology ; CD16 antigen ; CD57 antigen ; Cell differentiation ; Cloning ; Cytokines ; Cytomegalovirus ; Cytomegalovirus Infections ; Cytotoxicity ; Differentiation (biology) ; Disease prevention ; Hepatitis ; Humans ; Immune reconstitution ; Infections ; Inflammation ; Interleukin 10 ; Interleukin 6 ; Kidney transplantation ; Kidney Transplantation - adverse effects ; Kidney transplants ; Killer Cells, Natural ; Life Sciences ; Microbiology ; Natural killer cells ; NKG2 antigen ; Opportunist infection ; Opportunistic Infections ; Plasma ; Proteins ; Research centers ; Signatures ; Software ; Viral infections</subject><ispartof>Current microbiology, 2023-01, Vol.80 (1), p.9-9, Article 9</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022. 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CMVs as important drivers of natural killer (NK) cell differentiation has been indicated to prompt several phenotypic and functional alteration in these cells. We aimed to monitor the reconstitution of NK cells and change the signature of inflammatory proteins at the critical phase of CMV reactivation over six months after kidney transplantation. The present study indicated that CMV reactivation is associated with the development of IL-6, IL-10, and cytotoxic granules, including granzyme-B and granulysin, and the drop in the frequency of CD16 + NKG2A-CD57 + NK cell subset in kidney transplant recipients (KTRs) with reactivation versus non- reactivated ones. Our findings describe distinct immune signatures that emerged with CMV reactivation after kidney transplantation, which may be helpful in the timely management of CMV infection in KTRs.</description><subject>Antibodies</subject><subject>Biomarkers</subject><subject>Biomedical and Life Sciences</subject><subject>Biotechnology</subject><subject>CD16 antigen</subject><subject>CD57 antigen</subject><subject>Cell differentiation</subject><subject>Cloning</subject><subject>Cytokines</subject><subject>Cytomegalovirus</subject><subject>Cytomegalovirus Infections</subject><subject>Cytotoxicity</subject><subject>Differentiation (biology)</subject><subject>Disease prevention</subject><subject>Hepatitis</subject><subject>Humans</subject><subject>Immune reconstitution</subject><subject>Infections</subject><subject>Inflammation</subject><subject>Interleukin 10</subject><subject>Interleukin 6</subject><subject>Kidney transplantation</subject><subject>Kidney Transplantation - adverse 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Signatures of Plasma Inflammatory Proteins and Phonotypic Markers of NK Cells in Kidney Transplant Patients upon CMV Reactivation</title><author>Soleimanian, Saeede ; Yaghobi, Ramin ; Karimi, Mohammad Hossein ; Geramizadeh, Bita ; Roozbeh, Jamshid</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c305t-c952844b1ae3ca676f3215cd14f9824b3570d359a89756f10cb23f644cd823723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Antibodies</topic><topic>Biomarkers</topic><topic>Biomedical and Life Sciences</topic><topic>Biotechnology</topic><topic>CD16 antigen</topic><topic>CD57 antigen</topic><topic>Cell differentiation</topic><topic>Cloning</topic><topic>Cytokines</topic><topic>Cytomegalovirus</topic><topic>Cytomegalovirus Infections</topic><topic>Cytotoxicity</topic><topic>Differentiation (biology)</topic><topic>Disease 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reactivation remains a common opportunistic infection with a prominent role in immune reconstitution in organ transplant recipients. CMVs as important drivers of natural killer (NK) cell differentiation has been indicated to prompt several phenotypic and functional alteration in these cells. We aimed to monitor the reconstitution of NK cells and change the signature of inflammatory proteins at the critical phase of CMV reactivation over six months after kidney transplantation. The present study indicated that CMV reactivation is associated with the development of IL-6, IL-10, and cytotoxic granules, including granzyme-B and granulysin, and the drop in the frequency of CD16 + NKG2A-CD57 + NK cell subset in kidney transplant recipients (KTRs) with reactivation versus non- reactivated ones. 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| subjects | Antibodies Biomarkers Biomedical and Life Sciences Biotechnology CD16 antigen CD57 antigen Cell differentiation Cloning Cytokines Cytomegalovirus Cytomegalovirus Infections Cytotoxicity Differentiation (biology) Disease prevention Hepatitis Humans Immune reconstitution Infections Inflammation Interleukin 10 Interleukin 6 Kidney transplantation Kidney Transplantation - adverse effects Kidney transplants Killer Cells, Natural Life Sciences Microbiology Natural killer cells NKG2 antigen Opportunist infection Opportunistic Infections Plasma Proteins Research centers Signatures Software Viral infections |
| title | Altered Signatures of Plasma Inflammatory Proteins and Phonotypic Markers of NK Cells in Kidney Transplant Patients upon CMV Reactivation |
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