Acute physiological responses to high-intensity interval exercise in patients with coronary artery disease
Purpose Time spent closer to maximal effort during exercise is a potent stimulus for cardiorespiratory adaptations. The primary purpose was to determine which high-intensity interval exercise (HIIE) protocol provided the greatest physiological stimulus by comparing time spent ≥ 90% peak oxygen consu...
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| Veröffentlicht in: | European journal of applied physiology 2023-04, Vol.123 (4), p.737-747 |
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| creator | Currie, Katharine D. Dizonno, Vanessa Oh, Paul I. Goodman, Jack M. |
| description | Purpose
Time spent closer to maximal effort during exercise is a potent stimulus for cardiorespiratory adaptations. The primary purpose was to determine which high-intensity interval exercise (HIIE) protocol provided the greatest physiological stimulus by comparing time spent ≥ 90% peak oxygen consumption (V̇O
2
peak) and heart rate reserve (HRR) in patients with coronary artery disease (CAD) in response to 3 HIIE protocols and the exercise standard of care, moderate-intensity continuous exercise (MICE). A secondary purpose was to assess protocol preference.
Methods
Fifteen patients with CAD (6 females, 67 ± 6 years) underwent measurements of V̇O
2
and heart rate during MICE and three HIIE protocols all performed on a treadmill. The HIIE protocols included one with long intervals (4 × 4-min), short intervals (10 × 1-min), and an adapted version of the 4 × 4 [Toronto Rehabilitation Institute Protocol, (TRIP)]. Time spent ≥ 90% V̇O
2
peak and HRR were compared.
Results
Time spent ≥ 90% V̇O
2
peak was higher during 4 × 4 (6.3 ± 8.4 min) vs. MICE (1.7 ± 3.9 min;
P
= 0.001), while time spent ≥ 90% HRR was higher during 4 × 4 (6.0 ± 5.3 min) vs. MICE (0.1 ± 0.2 min;
P
|
| doi_str_mv | 10.1007/s00421-022-05102-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2742658315</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2742658315</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-687fcf4f48c6a04ba4b3196b89409360482045e39a09d29ac674098aaf4fbfba3</originalsourceid><addsrcrecordid>eNp9kcuO1DAQRS0EYh7wAyyQJTZsAuVHEns5Gg0PaSQ2sLYcd6XbrXQcXA5M_z0eehgkFqxccp17y-XL2CsB7wRA_54AtBQNSNlAK0A28gk7F1rZplOyf_pYC3vGLoj2AGCkMM_Zmeq0brXV52x_FdaCfNkdKaYpbWPwE89IS5oJiZfEd3G7a-JccKZYjvy-yj8qhHeYQySsN3zxJeJciP-MZcdDymn2-ch9ruyRbyrlCV-wZ6OfCF8-nJfs24ebr9efmtsvHz9fX902QfVtaTrTj2HUozah86AHr4e6QTcYq8GqDrSRoFtU1oPdSOtD19eG8b5qhnHw6pK9PfkuOX1fkYo7RAo4TX7GtJKTvZZda5RoK_rmH3Sf1jzX11XKWAArDFRKnqiQE1HG0S05HuqCToC7T8KdknA1Cfc7CSer6PWD9ToccPMo-fP1FVAngGpr3mL-O_s_tr8AGEmU8Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2789009180</pqid></control><display><type>article</type><title>Acute physiological responses to high-intensity interval exercise in patients with coronary artery disease</title><source>MEDLINE</source><source>SpringerLink</source><creator>Currie, Katharine D. ; Dizonno, Vanessa ; Oh, Paul I. ; Goodman, Jack M.</creator><creatorcontrib>Currie, Katharine D. ; Dizonno, Vanessa ; Oh, Paul I. ; Goodman, Jack M.</creatorcontrib><description>Purpose
Time spent closer to maximal effort during exercise is a potent stimulus for cardiorespiratory adaptations. The primary purpose was to determine which high-intensity interval exercise (HIIE) protocol provided the greatest physiological stimulus by comparing time spent ≥ 90% peak oxygen consumption (V̇O
2
peak) and heart rate reserve (HRR) in patients with coronary artery disease (CAD) in response to 3 HIIE protocols and the exercise standard of care, moderate-intensity continuous exercise (MICE). A secondary purpose was to assess protocol preference.
Methods
Fifteen patients with CAD (6 females, 67 ± 6 years) underwent measurements of V̇O
2
and heart rate during MICE and three HIIE protocols all performed on a treadmill. The HIIE protocols included one with long intervals (4 × 4-min), short intervals (10 × 1-min), and an adapted version of the 4 × 4 [Toronto Rehabilitation Institute Protocol, (TRIP)]. Time spent ≥ 90% V̇O
2
peak and HRR were compared.
Results
Time spent ≥ 90% V̇O
2
peak was higher during 4 × 4 (6.3 ± 8.4 min) vs. MICE (1.7 ± 3.9 min;
P
= 0.001), while time spent ≥ 90% HRR was higher during 4 × 4 (6.0 ± 5.3 min) vs. MICE (0.1 ± 0.2 min;
P
< 0.001) and 10 × 1 (0.7 ± 0.8 min;
P
= 0.016). TRIP had similar responses as 10 × 1 and MICE. The 10 × 1 was the most preferred protocol and the 4 × 4 was the least preferred protocol.
Conclusion
Longer intervals (4 × 4) provided the greatest physiological stimulus compared to the exercise standard of care and shorter intervals. However, this protocol was least preferred which may impact exercise adherence. Although the physiological stimulus is important to maximize training adaptations, exercise preferences and attitudes should be considered.</description><identifier>ISSN: 1439-6319</identifier><identifier>EISSN: 1439-6327</identifier><identifier>DOI: 10.1007/s00421-022-05102-2</identifier><identifier>PMID: 36445494</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adaptation ; Biomedical and Life Sciences ; Biomedicine ; Cardiovascular disease ; Coronary Artery Disease ; Coronary vessels ; Exercise - physiology ; Female ; Heart diseases ; Heart Rate ; High-Intensity Interval Training - methods ; Human Physiology ; Humans ; Occupational Medicine/Industrial Medicine ; Original Article ; Oxygen consumption ; Oxygen Consumption - physiology ; Physical training ; Physiology ; Rehabilitation ; Sports Medicine ; Vein & artery diseases</subject><ispartof>European journal of applied physiology, 2023-04, Vol.123 (4), p.737-747</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-687fcf4f48c6a04ba4b3196b89409360482045e39a09d29ac674098aaf4fbfba3</citedby><cites>FETCH-LOGICAL-c375t-687fcf4f48c6a04ba4b3196b89409360482045e39a09d29ac674098aaf4fbfba3</cites><orcidid>0000-0002-9072-7056 ; 0000-0001-8098-0018 ; 0000-0002-0603-6958 ; 0000-0003-1487-4975</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00421-022-05102-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00421-022-05102-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,782,786,27933,27934,41497,42566,51328</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36445494$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Currie, Katharine D.</creatorcontrib><creatorcontrib>Dizonno, Vanessa</creatorcontrib><creatorcontrib>Oh, Paul I.</creatorcontrib><creatorcontrib>Goodman, Jack M.</creatorcontrib><title>Acute physiological responses to high-intensity interval exercise in patients with coronary artery disease</title><title>European journal of applied physiology</title><addtitle>Eur J Appl Physiol</addtitle><addtitle>Eur J Appl Physiol</addtitle><description>Purpose
Time spent closer to maximal effort during exercise is a potent stimulus for cardiorespiratory adaptations. The primary purpose was to determine which high-intensity interval exercise (HIIE) protocol provided the greatest physiological stimulus by comparing time spent ≥ 90% peak oxygen consumption (V̇O
2
peak) and heart rate reserve (HRR) in patients with coronary artery disease (CAD) in response to 3 HIIE protocols and the exercise standard of care, moderate-intensity continuous exercise (MICE). A secondary purpose was to assess protocol preference.
Methods
Fifteen patients with CAD (6 females, 67 ± 6 years) underwent measurements of V̇O
2
and heart rate during MICE and three HIIE protocols all performed on a treadmill. The HIIE protocols included one with long intervals (4 × 4-min), short intervals (10 × 1-min), and an adapted version of the 4 × 4 [Toronto Rehabilitation Institute Protocol, (TRIP)]. Time spent ≥ 90% V̇O
2
peak and HRR were compared.
Results
Time spent ≥ 90% V̇O
2
peak was higher during 4 × 4 (6.3 ± 8.4 min) vs. MICE (1.7 ± 3.9 min;
P
= 0.001), while time spent ≥ 90% HRR was higher during 4 × 4 (6.0 ± 5.3 min) vs. MICE (0.1 ± 0.2 min;
P
< 0.001) and 10 × 1 (0.7 ± 0.8 min;
P
= 0.016). TRIP had similar responses as 10 × 1 and MICE. The 10 × 1 was the most preferred protocol and the 4 × 4 was the least preferred protocol.
Conclusion
Longer intervals (4 × 4) provided the greatest physiological stimulus compared to the exercise standard of care and shorter intervals. However, this protocol was least preferred which may impact exercise adherence. Although the physiological stimulus is important to maximize training adaptations, exercise preferences and attitudes should be considered.</description><subject>Adaptation</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cardiovascular disease</subject><subject>Coronary Artery Disease</subject><subject>Coronary vessels</subject><subject>Exercise - physiology</subject><subject>Female</subject><subject>Heart diseases</subject><subject>Heart Rate</subject><subject>High-Intensity Interval Training - methods</subject><subject>Human Physiology</subject><subject>Humans</subject><subject>Occupational Medicine/Industrial Medicine</subject><subject>Original Article</subject><subject>Oxygen consumption</subject><subject>Oxygen Consumption - physiology</subject><subject>Physical training</subject><subject>Physiology</subject><subject>Rehabilitation</subject><subject>Sports Medicine</subject><subject>Vein & artery diseases</subject><issn>1439-6319</issn><issn>1439-6327</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kcuO1DAQRS0EYh7wAyyQJTZsAuVHEns5Gg0PaSQ2sLYcd6XbrXQcXA5M_z0eehgkFqxccp17y-XL2CsB7wRA_54AtBQNSNlAK0A28gk7F1rZplOyf_pYC3vGLoj2AGCkMM_Zmeq0brXV52x_FdaCfNkdKaYpbWPwE89IS5oJiZfEd3G7a-JccKZYjvy-yj8qhHeYQySsN3zxJeJciP-MZcdDymn2-ch9ruyRbyrlCV-wZ6OfCF8-nJfs24ebr9efmtsvHz9fX902QfVtaTrTj2HUozah86AHr4e6QTcYq8GqDrSRoFtU1oPdSOtD19eG8b5qhnHw6pK9PfkuOX1fkYo7RAo4TX7GtJKTvZZda5RoK_rmH3Sf1jzX11XKWAArDFRKnqiQE1HG0S05HuqCToC7T8KdknA1Cfc7CSer6PWD9ToccPMo-fP1FVAngGpr3mL-O_s_tr8AGEmU8Q</recordid><startdate>20230401</startdate><enddate>20230401</enddate><creator>Currie, Katharine D.</creator><creator>Dizonno, Vanessa</creator><creator>Oh, Paul I.</creator><creator>Goodman, Jack M.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9072-7056</orcidid><orcidid>https://orcid.org/0000-0001-8098-0018</orcidid><orcidid>https://orcid.org/0000-0002-0603-6958</orcidid><orcidid>https://orcid.org/0000-0003-1487-4975</orcidid></search><sort><creationdate>20230401</creationdate><title>Acute physiological responses to high-intensity interval exercise in patients with coronary artery disease</title><author>Currie, Katharine D. ; Dizonno, Vanessa ; Oh, Paul I. ; Goodman, Jack M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-687fcf4f48c6a04ba4b3196b89409360482045e39a09d29ac674098aaf4fbfba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adaptation</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cardiovascular disease</topic><topic>Coronary Artery Disease</topic><topic>Coronary vessels</topic><topic>Exercise - physiology</topic><topic>Female</topic><topic>Heart diseases</topic><topic>Heart Rate</topic><topic>High-Intensity Interval Training - methods</topic><topic>Human Physiology</topic><topic>Humans</topic><topic>Occupational Medicine/Industrial Medicine</topic><topic>Original Article</topic><topic>Oxygen consumption</topic><topic>Oxygen Consumption - physiology</topic><topic>Physical training</topic><topic>Physiology</topic><topic>Rehabilitation</topic><topic>Sports Medicine</topic><topic>Vein & artery diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Currie, Katharine D.</creatorcontrib><creatorcontrib>Dizonno, Vanessa</creatorcontrib><creatorcontrib>Oh, Paul I.</creatorcontrib><creatorcontrib>Goodman, Jack M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of applied physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Currie, Katharine D.</au><au>Dizonno, Vanessa</au><au>Oh, Paul I.</au><au>Goodman, Jack M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute physiological responses to high-intensity interval exercise in patients with coronary artery disease</atitle><jtitle>European journal of applied physiology</jtitle><stitle>Eur J Appl Physiol</stitle><addtitle>Eur J Appl Physiol</addtitle><date>2023-04-01</date><risdate>2023</risdate><volume>123</volume><issue>4</issue><spage>737</spage><epage>747</epage><pages>737-747</pages><issn>1439-6319</issn><eissn>1439-6327</eissn><abstract>Purpose
Time spent closer to maximal effort during exercise is a potent stimulus for cardiorespiratory adaptations. The primary purpose was to determine which high-intensity interval exercise (HIIE) protocol provided the greatest physiological stimulus by comparing time spent ≥ 90% peak oxygen consumption (V̇O
2
peak) and heart rate reserve (HRR) in patients with coronary artery disease (CAD) in response to 3 HIIE protocols and the exercise standard of care, moderate-intensity continuous exercise (MICE). A secondary purpose was to assess protocol preference.
Methods
Fifteen patients with CAD (6 females, 67 ± 6 years) underwent measurements of V̇O
2
and heart rate during MICE and three HIIE protocols all performed on a treadmill. The HIIE protocols included one with long intervals (4 × 4-min), short intervals (10 × 1-min), and an adapted version of the 4 × 4 [Toronto Rehabilitation Institute Protocol, (TRIP)]. Time spent ≥ 90% V̇O
2
peak and HRR were compared.
Results
Time spent ≥ 90% V̇O
2
peak was higher during 4 × 4 (6.3 ± 8.4 min) vs. MICE (1.7 ± 3.9 min;
P
= 0.001), while time spent ≥ 90% HRR was higher during 4 × 4 (6.0 ± 5.3 min) vs. MICE (0.1 ± 0.2 min;
P
< 0.001) and 10 × 1 (0.7 ± 0.8 min;
P
= 0.016). TRIP had similar responses as 10 × 1 and MICE. The 10 × 1 was the most preferred protocol and the 4 × 4 was the least preferred protocol.
Conclusion
Longer intervals (4 × 4) provided the greatest physiological stimulus compared to the exercise standard of care and shorter intervals. However, this protocol was least preferred which may impact exercise adherence. Although the physiological stimulus is important to maximize training adaptations, exercise preferences and attitudes should be considered.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>36445494</pmid><doi>10.1007/s00421-022-05102-2</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-9072-7056</orcidid><orcidid>https://orcid.org/0000-0001-8098-0018</orcidid><orcidid>https://orcid.org/0000-0002-0603-6958</orcidid><orcidid>https://orcid.org/0000-0003-1487-4975</orcidid></addata></record> |
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| source | MEDLINE; SpringerLink |
| subjects | Adaptation Biomedical and Life Sciences Biomedicine Cardiovascular disease Coronary Artery Disease Coronary vessels Exercise - physiology Female Heart diseases Heart Rate High-Intensity Interval Training - methods Human Physiology Humans Occupational Medicine/Industrial Medicine Original Article Oxygen consumption Oxygen Consumption - physiology Physical training Physiology Rehabilitation Sports Medicine Vein & artery diseases |
| title | Acute physiological responses to high-intensity interval exercise in patients with coronary artery disease |
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