Development, validation, and implementation of a robust and quality control-friendly focused peptide mapping method for monitoring oxidation of co-formulated monoclonal antibodies

Monoclonal antibody (mAb) coformulation containing two therapeutic proteins provides benefits of improved therapeutic efficacy and better patient compliance. Monitoring of the individual mAb stability in the coformulation is critical to ensure its quality and safety. Among post-translational modific...

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Veröffentlicht in:	Analytical and bioanalytical chemistry 2022-12, Vol.414 (29-30), p.8317-8330
Hauptverfasser:	Xu, Chengdong, Khanal, Sumee, Pierson, Nicholas A., Quiroz, Jorge, Kochert, Brent, Yang, Xiaoyu, Wylie, David, Strulson, Christopher A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Analytical Chemistry Biochemistry Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Chromatography Food Science Hydrophobicity Interactomes Laboratories Laboratory Medicine Liquid chromatography Mass spectrometry Mass spectroscopy Methionine Methods Monitoring Monitoring methods Monitoring/Environmental Analysis Monoclonal antibodies Oxidation Oxidation-reduction reaction Peptide mapping Peptides Post-translation Proteins Quadrupoles Quality control Quality management Quantitation Research Paper Robust control Sample preparation Selectivity Stability analysis Tryptophan
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