Pharmacological evaluation of antinociceptive and anti-inflammatory activities of LQFM202: a new piperazine derivative

Advances have been made in the search for new multi-target modulators to control pain and inflammation. Therefore, compound 3,5-di-tert-butyl-4-hydroxyphenyl)(4-methylpiperazin-1-yl)methanone (LQFM202) was synthesised and evaluated. First, in vitro assays were performed for COX-1, COX-2, and 5-LOX e...

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Veröffentlicht in:	Inflammopharmacology 2023-02, Vol.31 (1), p.411-422
Hauptverfasser:	Martins, Aline N., de Souza Almeida, Dionys, Florentino, Iziara F., da Silva Moreira, Lorrane K., Turones, Larissa C., Batista, Daniel C., Machado, Lucas S., Vaz, Boniek G., Lião, Luciano M., de Almeida Ribeiro Oliveira, Gerlon, Martins, José Luís Rodrigues, Fajemiroye, James Oluwagbamigbe, Menegatti, Ricardo, Costa, Elson A., da Silva, Daiany P. B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergology Biomedical and Life Sciences Biomedicine Dermatology Gastroenterology Immunology Original Article Pharmacology/Toxicology Rheumatology
Online-Zugang:	Volltext
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