Real‐world assessment of SmartExam, a novel FibroScan computational method: A retrospective single‐center cohort study
Background and Aim SmartExam is a novel computational method compatible with FibroScan that uses a software called SmartDepth and continuous controlled attenuation parameter measurements to evaluate liver fibrosis and steatosis. This retrospective study compared the diagnostic accuracy of convention...
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| Veröffentlicht in: | Journal of gastroenterology and hepatology 2023-02, Vol.38 (2), p.321-329 |
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| creator | Nogami, Asako Iwaki, Michihiro Kobayashi, Takashi Honda, Yasushi Ogawa, Yuji Imajo, Kento Higurashi, Takuma Hosono, Kunihiro Kirikoshi, Hiroyuki Saito, Satoru Nakajima, Atsushi Yoneda, Masato |
| description | Background and Aim
SmartExam is a novel computational method compatible with FibroScan that uses a software called SmartDepth and continuous controlled attenuation parameter measurements to evaluate liver fibrosis and steatosis. This retrospective study compared the diagnostic accuracy of conventional and SmartExam‐equipped FibroScan for liver stiffness measurement (LSM).
Methods
The liver stiffness and the associated controlled attenuation parameters of 167 patients were measured using conventional and SmartExam‐Equipped FibroScan as well as reference methods like magnetic resonance elastography (MRE) and magnetic resonance imaging‐based proton density fat fraction (MRI‐PDFF) measurements to assess its diagnostic performance. M or XL probes were selected based on the probe‐to‐liver capsule distance for all FibroScan examinations.
Results
The liver stiffness and controlled attenuation parameter (CAP) correlation coefficients calculated from conventional and SmartExam‐equipped FibroScan were 0.97 and 0.82, respectively. Using MRE/MRI‐PDFF as a reference and the DeLong test for analysis, LSM and the area under the receiver operating characteristic curve for CAP measured by conventional and SmartExam‐equipped FibroScan showed no significant difference. However, the SmartExam‐equipped FibroScan measurement (33.6 s) took 1.4 times longer than conventional FibroScan (23.2 s).
Conclusions
SmartExam has a high diagnostic performance comparable with that of conventional FibroScan. Because the results of the conventional and SmartExam‐equipped FibroScan were strongly correlated, it can be considered useful for assessing the fibrosis stage and steatosis grade of the liver in clinical practice, with less variability but little longer measurement time compared with the conventional FibroScan. |
| doi_str_mv | 10.1111/jgh.16076 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2740908935</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2774047243</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2836-560e404548b944f0bb30396dd710f7b08e02d992b9382c9eb204bfcc384a49243</originalsourceid><addsrcrecordid>eNp1kctOHDEQRS0UFCYkC34gssQmSGkot90PZ4cQrwgJKcC6ZburmR652xPbDUxW-YR8Y74EwxAWSKlNbU4d6dYlZIfBPktzsLid77MSqnKDzJgQkLFKlO_IDGpWZJIzuUU-hLAAAAFV8Z5s8VLwsq7kjPz6gcr-_f3n3nnbUhUChjDgGKnr6NWgfDx-UMNXqujo7tDSk157d2XUSI0bllNUsXejsnTAOHftN3pIPUbvwhJN7O-Qhn68tZj8JjnRp6u585GGOLWrj2SzUzbgp5e9TW5Ojq-PzrKLy9Pzo8OLzOQ1L7OiBBQgClFrKUQHWnPgsmzbikFXaagR8lbKXEte50aizkHozhheCyVkLvg2-bL2Lr37OWGIzdAHg9aqEd0UmrwSIKGWvEjo7ht04SafAj5RCRNV8iVqb02ZlDR47Jql79OvVg2D5qmQJhXSPBeS2M8vxkkP2L6S_xpIwMEauO8trv5var6fnq2Vj5kklt8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2774047243</pqid></control><display><type>article</type><title>Real‐world assessment of SmartExam, a novel FibroScan computational method: A retrospective single‐center cohort study</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Nogami, Asako ; Iwaki, Michihiro ; Kobayashi, Takashi ; Honda, Yasushi ; Ogawa, Yuji ; Imajo, Kento ; Higurashi, Takuma ; Hosono, Kunihiro ; Kirikoshi, Hiroyuki ; Saito, Satoru ; Nakajima, Atsushi ; Yoneda, Masato</creator><creatorcontrib>Nogami, Asako ; Iwaki, Michihiro ; Kobayashi, Takashi ; Honda, Yasushi ; Ogawa, Yuji ; Imajo, Kento ; Higurashi, Takuma ; Hosono, Kunihiro ; Kirikoshi, Hiroyuki ; Saito, Satoru ; Nakajima, Atsushi ; Yoneda, Masato</creatorcontrib><description>Background and Aim
SmartExam is a novel computational method compatible with FibroScan that uses a software called SmartDepth and continuous controlled attenuation parameter measurements to evaluate liver fibrosis and steatosis. This retrospective study compared the diagnostic accuracy of conventional and SmartExam‐equipped FibroScan for liver stiffness measurement (LSM).
Methods
The liver stiffness and the associated controlled attenuation parameters of 167 patients were measured using conventional and SmartExam‐Equipped FibroScan as well as reference methods like magnetic resonance elastography (MRE) and magnetic resonance imaging‐based proton density fat fraction (MRI‐PDFF) measurements to assess its diagnostic performance. M or XL probes were selected based on the probe‐to‐liver capsule distance for all FibroScan examinations.
Results
The liver stiffness and controlled attenuation parameter (CAP) correlation coefficients calculated from conventional and SmartExam‐equipped FibroScan were 0.97 and 0.82, respectively. Using MRE/MRI‐PDFF as a reference and the DeLong test for analysis, LSM and the area under the receiver operating characteristic curve for CAP measured by conventional and SmartExam‐equipped FibroScan showed no significant difference. However, the SmartExam‐equipped FibroScan measurement (33.6 s) took 1.4 times longer than conventional FibroScan (23.2 s).
Conclusions
SmartExam has a high diagnostic performance comparable with that of conventional FibroScan. Because the results of the conventional and SmartExam‐equipped FibroScan were strongly correlated, it can be considered useful for assessing the fibrosis stage and steatosis grade of the liver in clinical practice, with less variability but little longer measurement time compared with the conventional FibroScan.</description><identifier>ISSN: 0815-9319</identifier><identifier>EISSN: 1440-1746</identifier><identifier>DOI: 10.1111/jgh.16076</identifier><identifier>PMID: 36436879</identifier><language>eng</language><publisher>Australia: Wiley Subscription Services, Inc</publisher><subject>Biopsy ; chronic hepatitis ; Cohort analysis ; Cohort Studies ; Computer applications ; Elasticity Imaging Techniques - methods ; Fatty liver ; Fatty Liver - pathology ; Fibrosis ; Humans ; Liver ; Liver - pathology ; Liver Cirrhosis - etiology ; liver fibrosis ; liver steatosis ; Magnetic resonance imaging ; Non-alcoholic Fatty Liver Disease - complications ; noninvasive tests ; Retrospective Studies ; ROC Curve ; Steatosis ; vibration‐controlled transient elastography</subject><ispartof>Journal of gastroenterology and hepatology, 2023-02, Vol.38 (2), p.321-329</ispartof><rights>2022 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.</rights><rights>2023 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2836-560e404548b944f0bb30396dd710f7b08e02d992b9382c9eb204bfcc384a49243</citedby><cites>FETCH-LOGICAL-c2836-560e404548b944f0bb30396dd710f7b08e02d992b9382c9eb204bfcc384a49243</cites><orcidid>0000-0002-6263-1436 ; 0000-0002-1815-4396 ; 0000-0002-6923-365X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjgh.16076$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjgh.16076$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36436879$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nogami, Asako</creatorcontrib><creatorcontrib>Iwaki, Michihiro</creatorcontrib><creatorcontrib>Kobayashi, Takashi</creatorcontrib><creatorcontrib>Honda, Yasushi</creatorcontrib><creatorcontrib>Ogawa, Yuji</creatorcontrib><creatorcontrib>Imajo, Kento</creatorcontrib><creatorcontrib>Higurashi, Takuma</creatorcontrib><creatorcontrib>Hosono, Kunihiro</creatorcontrib><creatorcontrib>Kirikoshi, Hiroyuki</creatorcontrib><creatorcontrib>Saito, Satoru</creatorcontrib><creatorcontrib>Nakajima, Atsushi</creatorcontrib><creatorcontrib>Yoneda, Masato</creatorcontrib><title>Real‐world assessment of SmartExam, a novel FibroScan computational method: A retrospective single‐center cohort study</title><title>Journal of gastroenterology and hepatology</title><addtitle>J Gastroenterol Hepatol</addtitle><description>Background and Aim
SmartExam is a novel computational method compatible with FibroScan that uses a software called SmartDepth and continuous controlled attenuation parameter measurements to evaluate liver fibrosis and steatosis. This retrospective study compared the diagnostic accuracy of conventional and SmartExam‐equipped FibroScan for liver stiffness measurement (LSM).
Methods
The liver stiffness and the associated controlled attenuation parameters of 167 patients were measured using conventional and SmartExam‐Equipped FibroScan as well as reference methods like magnetic resonance elastography (MRE) and magnetic resonance imaging‐based proton density fat fraction (MRI‐PDFF) measurements to assess its diagnostic performance. M or XL probes were selected based on the probe‐to‐liver capsule distance for all FibroScan examinations.
Results
The liver stiffness and controlled attenuation parameter (CAP) correlation coefficients calculated from conventional and SmartExam‐equipped FibroScan were 0.97 and 0.82, respectively. Using MRE/MRI‐PDFF as a reference and the DeLong test for analysis, LSM and the area under the receiver operating characteristic curve for CAP measured by conventional and SmartExam‐equipped FibroScan showed no significant difference. However, the SmartExam‐equipped FibroScan measurement (33.6 s) took 1.4 times longer than conventional FibroScan (23.2 s).
Conclusions
SmartExam has a high diagnostic performance comparable with that of conventional FibroScan. Because the results of the conventional and SmartExam‐equipped FibroScan were strongly correlated, it can be considered useful for assessing the fibrosis stage and steatosis grade of the liver in clinical practice, with less variability but little longer measurement time compared with the conventional FibroScan.</description><subject>Biopsy</subject><subject>chronic hepatitis</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Computer applications</subject><subject>Elasticity Imaging Techniques - methods</subject><subject>Fatty liver</subject><subject>Fatty Liver - pathology</subject><subject>Fibrosis</subject><subject>Humans</subject><subject>Liver</subject><subject>Liver - pathology</subject><subject>Liver Cirrhosis - etiology</subject><subject>liver fibrosis</subject><subject>liver steatosis</subject><subject>Magnetic resonance imaging</subject><subject>Non-alcoholic Fatty Liver Disease - complications</subject><subject>noninvasive tests</subject><subject>Retrospective Studies</subject><subject>ROC Curve</subject><subject>Steatosis</subject><subject>vibration‐controlled transient elastography</subject><issn>0815-9319</issn><issn>1440-1746</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctOHDEQRS0UFCYkC34gssQmSGkot90PZ4cQrwgJKcC6ZburmR652xPbDUxW-YR8Y74EwxAWSKlNbU4d6dYlZIfBPktzsLid77MSqnKDzJgQkLFKlO_IDGpWZJIzuUU-hLAAAAFV8Z5s8VLwsq7kjPz6gcr-_f3n3nnbUhUChjDgGKnr6NWgfDx-UMNXqujo7tDSk157d2XUSI0bllNUsXejsnTAOHftN3pIPUbvwhJN7O-Qhn68tZj8JjnRp6u585GGOLWrj2SzUzbgp5e9TW5Ojq-PzrKLy9Pzo8OLzOQ1L7OiBBQgClFrKUQHWnPgsmzbikFXaagR8lbKXEte50aizkHozhheCyVkLvg2-bL2Lr37OWGIzdAHg9aqEd0UmrwSIKGWvEjo7ht04SafAj5RCRNV8iVqb02ZlDR47Jql79OvVg2D5qmQJhXSPBeS2M8vxkkP2L6S_xpIwMEauO8trv5var6fnq2Vj5kklt8</recordid><startdate>202302</startdate><enddate>202302</enddate><creator>Nogami, Asako</creator><creator>Iwaki, Michihiro</creator><creator>Kobayashi, Takashi</creator><creator>Honda, Yasushi</creator><creator>Ogawa, Yuji</creator><creator>Imajo, Kento</creator><creator>Higurashi, Takuma</creator><creator>Hosono, Kunihiro</creator><creator>Kirikoshi, Hiroyuki</creator><creator>Saito, Satoru</creator><creator>Nakajima, Atsushi</creator><creator>Yoneda, Masato</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6263-1436</orcidid><orcidid>https://orcid.org/0000-0002-1815-4396</orcidid><orcidid>https://orcid.org/0000-0002-6923-365X</orcidid></search><sort><creationdate>202302</creationdate><title>Real‐world assessment of SmartExam, a novel FibroScan computational method: A retrospective single‐center cohort study</title><author>Nogami, Asako ; Iwaki, Michihiro ; Kobayashi, Takashi ; Honda, Yasushi ; Ogawa, Yuji ; Imajo, Kento ; Higurashi, Takuma ; Hosono, Kunihiro ; Kirikoshi, Hiroyuki ; Saito, Satoru ; Nakajima, Atsushi ; Yoneda, Masato</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2836-560e404548b944f0bb30396dd710f7b08e02d992b9382c9eb204bfcc384a49243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Biopsy</topic><topic>chronic hepatitis</topic><topic>Cohort analysis</topic><topic>Cohort Studies</topic><topic>Computer applications</topic><topic>Elasticity Imaging Techniques - methods</topic><topic>Fatty liver</topic><topic>Fatty Liver - pathology</topic><topic>Fibrosis</topic><topic>Humans</topic><topic>Liver</topic><topic>Liver - pathology</topic><topic>Liver Cirrhosis - etiology</topic><topic>liver fibrosis</topic><topic>liver steatosis</topic><topic>Magnetic resonance imaging</topic><topic>Non-alcoholic Fatty Liver Disease - complications</topic><topic>noninvasive tests</topic><topic>Retrospective Studies</topic><topic>ROC Curve</topic><topic>Steatosis</topic><topic>vibration‐controlled transient elastography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nogami, Asako</creatorcontrib><creatorcontrib>Iwaki, Michihiro</creatorcontrib><creatorcontrib>Kobayashi, Takashi</creatorcontrib><creatorcontrib>Honda, Yasushi</creatorcontrib><creatorcontrib>Ogawa, Yuji</creatorcontrib><creatorcontrib>Imajo, Kento</creatorcontrib><creatorcontrib>Higurashi, Takuma</creatorcontrib><creatorcontrib>Hosono, Kunihiro</creatorcontrib><creatorcontrib>Kirikoshi, Hiroyuki</creatorcontrib><creatorcontrib>Saito, Satoru</creatorcontrib><creatorcontrib>Nakajima, Atsushi</creatorcontrib><creatorcontrib>Yoneda, Masato</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastroenterology and hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nogami, Asako</au><au>Iwaki, Michihiro</au><au>Kobayashi, Takashi</au><au>Honda, Yasushi</au><au>Ogawa, Yuji</au><au>Imajo, Kento</au><au>Higurashi, Takuma</au><au>Hosono, Kunihiro</au><au>Kirikoshi, Hiroyuki</au><au>Saito, Satoru</au><au>Nakajima, Atsushi</au><au>Yoneda, Masato</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Real‐world assessment of SmartExam, a novel FibroScan computational method: A retrospective single‐center cohort study</atitle><jtitle>Journal of gastroenterology and hepatology</jtitle><addtitle>J Gastroenterol Hepatol</addtitle><date>2023-02</date><risdate>2023</risdate><volume>38</volume><issue>2</issue><spage>321</spage><epage>329</epage><pages>321-329</pages><issn>0815-9319</issn><eissn>1440-1746</eissn><abstract>Background and Aim
SmartExam is a novel computational method compatible with FibroScan that uses a software called SmartDepth and continuous controlled attenuation parameter measurements to evaluate liver fibrosis and steatosis. This retrospective study compared the diagnostic accuracy of conventional and SmartExam‐equipped FibroScan for liver stiffness measurement (LSM).
Methods
The liver stiffness and the associated controlled attenuation parameters of 167 patients were measured using conventional and SmartExam‐Equipped FibroScan as well as reference methods like magnetic resonance elastography (MRE) and magnetic resonance imaging‐based proton density fat fraction (MRI‐PDFF) measurements to assess its diagnostic performance. M or XL probes were selected based on the probe‐to‐liver capsule distance for all FibroScan examinations.
Results
The liver stiffness and controlled attenuation parameter (CAP) correlation coefficients calculated from conventional and SmartExam‐equipped FibroScan were 0.97 and 0.82, respectively. Using MRE/MRI‐PDFF as a reference and the DeLong test for analysis, LSM and the area under the receiver operating characteristic curve for CAP measured by conventional and SmartExam‐equipped FibroScan showed no significant difference. However, the SmartExam‐equipped FibroScan measurement (33.6 s) took 1.4 times longer than conventional FibroScan (23.2 s).
Conclusions
SmartExam has a high diagnostic performance comparable with that of conventional FibroScan. Because the results of the conventional and SmartExam‐equipped FibroScan were strongly correlated, it can be considered useful for assessing the fibrosis stage and steatosis grade of the liver in clinical practice, with less variability but little longer measurement time compared with the conventional FibroScan.</abstract><cop>Australia</cop><pub>Wiley Subscription Services, Inc</pub><pmid>36436879</pmid><doi>10.1111/jgh.16076</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-6263-1436</orcidid><orcidid>https://orcid.org/0000-0002-1815-4396</orcidid><orcidid>https://orcid.org/0000-0002-6923-365X</orcidid></addata></record> |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Biopsy chronic hepatitis Cohort analysis Cohort Studies Computer applications Elasticity Imaging Techniques - methods Fatty liver Fatty Liver - pathology Fibrosis Humans Liver Liver - pathology Liver Cirrhosis - etiology liver fibrosis liver steatosis Magnetic resonance imaging Non-alcoholic Fatty Liver Disease - complications noninvasive tests Retrospective Studies ROC Curve Steatosis vibration‐controlled transient elastography |
| title | Real‐world assessment of SmartExam, a novel FibroScan computational method: A retrospective single‐center cohort study |
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