The PMN-MDSC – A key player in glucocorticoid resistance following combined physical and psychosocial trauma

[Display omitted] •CSC increased TLR2 expression in myeloid BM and spleen subpopulations.•CSC increased TLR4 expression in splenic PMN-MDSCs & monocytes/MO-MDSCs.•Ly6G+ but not Ly6G-depleted splenocytes of CSC mice develop in vitro GC resistance.•CSC shifts the LPS response to predominant IKK/NF...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2023-02, Vol.108, p.148-161
Hauptverfasser:	Kempter, Elena, Amoroso, Mattia, Kupfer, Sandra, Lupu, Ludmila, Kustermann, Monika, Scheurer, Jasmin, Baumann, Bernd, Wirth, Thomas, Gündel, Harald, Straub, Rainer H., Strauß, Gudrun, Huber-Lang, Markus, Langgartner, Dominik, Reber, Stefan O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chronic psychosocial stress Chronic subordinate colony housing (CSC) Glucocorticoid resistance Glucocorticoids - pharmacology Lipopolysaccharides Mice Monocytes Myeloid Cells Myeloid-derived suppressor cells (MDSCs) Myeloid-Derived Suppressor Cells - metabolism Neutrophils NF-kB Stress, Psychological Systemic inflammation
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