Wireless, closed-loop, smart bandage with integrated sensors and stimulators for advanced wound care and accelerated healing
‘Smart’ bandages based on multimodal wearable devices could enable real-time physiological monitoring and active intervention to promote healing of chronic wounds. However, there has been limited development in incorporation of both sensors and stimulators for the current smart bandage technologies....
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| Veröffentlicht in: | Nature biotechnology 2023-05, Vol.41 (5), p.652-662 |
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| creator | Jiang, Yuanwen Trotsyuk, Artem A. Niu, Simiao Henn, Dominic Chen, Kellen Shih, Chien-Chung Larson, Madelyn R. Mermin-Bunnell, Alana M. Mittal, Smiti Lai, Jian-Cheng Saberi, Aref Beard, Ethan Jing, Serena Zhong, Donglai Steele, Sydney R. Sun, Kefan Jain, Tanish Zhao, Eric Neimeth, Christopher R. Viana, Willian G. Tang, Jing Sivaraj, Dharshan Padmanabhan, Jagannath Rodrigues, Melanie Perrault, David P. Chattopadhyay, Arhana Maan, Zeshaan N. Leeolou, Melissa C. Bonham, Clark A. Kwon, Sun Hyung Kussie, Hudson C. Fischer, Katharina S. Gurusankar, Gurupranav Liang, Kui Zhang, Kailiang Nag, Ronjon Snyder, Michael P. Januszyk, Michael Gurtner, Geoffrey C. Bao, Zhenan |
| description | ‘Smart’ bandages based on multimodal wearable devices could enable real-time physiological monitoring and active intervention to promote healing of chronic wounds. However, there has been limited development in incorporation of both sensors and stimulators for the current smart bandage technologies. Additionally, while adhesive electrodes are essential for robust signal transduction, detachment of existing adhesive dressings can lead to secondary damage to delicate wound tissues without switchable adhesion. Here we overcome these issues by developing a flexible bioelectronic system consisting of wirelessly powered, closed-loop sensing and stimulation circuits with skin-interfacing hydrogel electrodes capable of on-demand adhesion and detachment. In mice, we demonstrate that our wound care system can continuously monitor skin impedance and temperature and deliver electrical stimulation in response to the wound environment. Across preclinical wound models, the treatment group healed ~25% more rapidly and with ~50% enhancement in dermal remodeling compared with control. Further, we observed activation of proregenerative genes in monocyte and macrophage cell populations, which may enhance tissue regeneration, neovascularization and dermal recovery.
A wireless ‘smart’ bandage stimulates wound healing. |
| doi_str_mv | 10.1038/s41587-022-01528-3 |
| format | Article |
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A wireless ‘smart’ bandage stimulates wound healing.</description><identifier>ISSN: 1087-0156</identifier><identifier>EISSN: 1546-1696</identifier><identifier>DOI: 10.1038/s41587-022-01528-3</identifier><identifier>PMID: 36424488</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>639/166/985 ; 639/301/923/1027 ; 692/308/2778 ; 692/699/578 ; 692/700/565 ; Adhesion ; Agriculture ; Animals ; Bandages ; Bioelectricity ; Bioinformatics ; Biomedical and Life Sciences ; Biomedical Engineering/Biotechnology ; Biomedicine ; Biotechnology ; Closed loops ; Electrical stimuli ; Electrodes ; Environment models ; Hydrogels ; Life Sciences ; Macrophages ; Medical dressings ; Mice ; Monitoring, Physiologic ; Monocytes ; Regeneration (physiology) ; Sensors ; Signal transduction ; Skin ; Stimulation ; Stimulators ; Tissue engineering ; Transcription activation ; Vascularization ; Wearable Electronic Devices ; Wearable technology ; Wound Healing</subject><ispartof>Nature biotechnology, 2023-05, Vol.41 (5), p.652-662</ispartof><rights>The Author(s), under exclusive licence to Springer Nature America, Inc. 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2022. The Author(s), under exclusive licence to Springer Nature America, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-43c288300bf263d4bcbef74b0a426b9aa65457d190385ed8d446396789614d863</citedby><cites>FETCH-LOGICAL-c375t-43c288300bf263d4bcbef74b0a426b9aa65457d190385ed8d446396789614d863</cites><orcidid>0000-0003-1973-2204 ; 0000-0002-6315-6921 ; 0000-0002-0972-1715 ; 0000-0001-9179-937X ; 0000-0002-0876-414X ; 0000-0002-7023-7850 ; 0000-0003-2574-0534 ; 0000-0003-1096-6637 ; 0000-0003-0784-7987 ; 0000-0001-9290-678X ; 0000-0002-8319-2479</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41587-022-01528-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41587-022-01528-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36424488$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jiang, Yuanwen</creatorcontrib><creatorcontrib>Trotsyuk, Artem A.</creatorcontrib><creatorcontrib>Niu, Simiao</creatorcontrib><creatorcontrib>Henn, Dominic</creatorcontrib><creatorcontrib>Chen, Kellen</creatorcontrib><creatorcontrib>Shih, Chien-Chung</creatorcontrib><creatorcontrib>Larson, Madelyn R.</creatorcontrib><creatorcontrib>Mermin-Bunnell, Alana M.</creatorcontrib><creatorcontrib>Mittal, Smiti</creatorcontrib><creatorcontrib>Lai, Jian-Cheng</creatorcontrib><creatorcontrib>Saberi, Aref</creatorcontrib><creatorcontrib>Beard, Ethan</creatorcontrib><creatorcontrib>Jing, Serena</creatorcontrib><creatorcontrib>Zhong, Donglai</creatorcontrib><creatorcontrib>Steele, Sydney R.</creatorcontrib><creatorcontrib>Sun, Kefan</creatorcontrib><creatorcontrib>Jain, Tanish</creatorcontrib><creatorcontrib>Zhao, Eric</creatorcontrib><creatorcontrib>Neimeth, Christopher R.</creatorcontrib><creatorcontrib>Viana, Willian G.</creatorcontrib><creatorcontrib>Tang, Jing</creatorcontrib><creatorcontrib>Sivaraj, Dharshan</creatorcontrib><creatorcontrib>Padmanabhan, Jagannath</creatorcontrib><creatorcontrib>Rodrigues, Melanie</creatorcontrib><creatorcontrib>Perrault, David P.</creatorcontrib><creatorcontrib>Chattopadhyay, Arhana</creatorcontrib><creatorcontrib>Maan, Zeshaan N.</creatorcontrib><creatorcontrib>Leeolou, Melissa C.</creatorcontrib><creatorcontrib>Bonham, Clark A.</creatorcontrib><creatorcontrib>Kwon, Sun Hyung</creatorcontrib><creatorcontrib>Kussie, Hudson C.</creatorcontrib><creatorcontrib>Fischer, Katharina S.</creatorcontrib><creatorcontrib>Gurusankar, Gurupranav</creatorcontrib><creatorcontrib>Liang, Kui</creatorcontrib><creatorcontrib>Zhang, Kailiang</creatorcontrib><creatorcontrib>Nag, Ronjon</creatorcontrib><creatorcontrib>Snyder, Michael P.</creatorcontrib><creatorcontrib>Januszyk, Michael</creatorcontrib><creatorcontrib>Gurtner, Geoffrey C.</creatorcontrib><creatorcontrib>Bao, Zhenan</creatorcontrib><title>Wireless, closed-loop, smart bandage with integrated sensors and stimulators for advanced wound care and accelerated healing</title><title>Nature biotechnology</title><addtitle>Nat Biotechnol</addtitle><addtitle>Nat Biotechnol</addtitle><description>‘Smart’ bandages based on multimodal wearable devices could enable real-time physiological monitoring and active intervention to promote healing of chronic wounds. However, there has been limited development in incorporation of both sensors and stimulators for the current smart bandage technologies. Additionally, while adhesive electrodes are essential for robust signal transduction, detachment of existing adhesive dressings can lead to secondary damage to delicate wound tissues without switchable adhesion. Here we overcome these issues by developing a flexible bioelectronic system consisting of wirelessly powered, closed-loop sensing and stimulation circuits with skin-interfacing hydrogel electrodes capable of on-demand adhesion and detachment. In mice, we demonstrate that our wound care system can continuously monitor skin impedance and temperature and deliver electrical stimulation in response to the wound environment. Across preclinical wound models, the treatment group healed ~25% more rapidly and with ~50% enhancement in dermal remodeling compared with control. Further, we observed activation of proregenerative genes in monocyte and macrophage cell populations, which may enhance tissue regeneration, neovascularization and dermal recovery.
A wireless ‘smart’ bandage stimulates wound healing.</description><subject>639/166/985</subject><subject>639/301/923/1027</subject><subject>692/308/2778</subject><subject>692/699/578</subject><subject>692/700/565</subject><subject>Adhesion</subject><subject>Agriculture</subject><subject>Animals</subject><subject>Bandages</subject><subject>Bioelectricity</subject><subject>Bioinformatics</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedical Engineering/Biotechnology</subject><subject>Biomedicine</subject><subject>Biotechnology</subject><subject>Closed loops</subject><subject>Electrical stimuli</subject><subject>Electrodes</subject><subject>Environment models</subject><subject>Hydrogels</subject><subject>Life Sciences</subject><subject>Macrophages</subject><subject>Medical dressings</subject><subject>Mice</subject><subject>Monitoring, Physiologic</subject><subject>Monocytes</subject><subject>Regeneration (physiology)</subject><subject>Sensors</subject><subject>Signal 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(Alumni)</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nature biotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jiang, Yuanwen</au><au>Trotsyuk, Artem A.</au><au>Niu, Simiao</au><au>Henn, Dominic</au><au>Chen, Kellen</au><au>Shih, Chien-Chung</au><au>Larson, Madelyn R.</au><au>Mermin-Bunnell, Alana M.</au><au>Mittal, Smiti</au><au>Lai, Jian-Cheng</au><au>Saberi, Aref</au><au>Beard, Ethan</au><au>Jing, Serena</au><au>Zhong, Donglai</au><au>Steele, Sydney R.</au><au>Sun, Kefan</au><au>Jain, Tanish</au><au>Zhao, Eric</au><au>Neimeth, Christopher R.</au><au>Viana, Willian G.</au><au>Tang, Jing</au><au>Sivaraj, Dharshan</au><au>Padmanabhan, Jagannath</au><au>Rodrigues, Melanie</au><au>Perrault, David P.</au><au>Chattopadhyay, Arhana</au><au>Maan, Zeshaan N.</au><au>Leeolou, Melissa C.</au><au>Bonham, Clark A.</au><au>Kwon, Sun Hyung</au><au>Kussie, Hudson C.</au><au>Fischer, Katharina S.</au><au>Gurusankar, Gurupranav</au><au>Liang, Kui</au><au>Zhang, Kailiang</au><au>Nag, Ronjon</au><au>Snyder, Michael P.</au><au>Januszyk, Michael</au><au>Gurtner, Geoffrey C.</au><au>Bao, Zhenan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Wireless, closed-loop, smart bandage with integrated sensors and stimulators for advanced wound care and accelerated healing</atitle><jtitle>Nature biotechnology</jtitle><stitle>Nat Biotechnol</stitle><addtitle>Nat Biotechnol</addtitle><date>2023-05-01</date><risdate>2023</risdate><volume>41</volume><issue>5</issue><spage>652</spage><epage>662</epage><pages>652-662</pages><issn>1087-0156</issn><eissn>1546-1696</eissn><abstract>‘Smart’ bandages based on multimodal wearable devices could enable real-time physiological monitoring and active intervention to promote healing of chronic wounds. However, there has been limited development in incorporation of both sensors and stimulators for the current smart bandage technologies. Additionally, while adhesive electrodes are essential for robust signal transduction, detachment of existing adhesive dressings can lead to secondary damage to delicate wound tissues without switchable adhesion. Here we overcome these issues by developing a flexible bioelectronic system consisting of wirelessly powered, closed-loop sensing and stimulation circuits with skin-interfacing hydrogel electrodes capable of on-demand adhesion and detachment. In mice, we demonstrate that our wound care system can continuously monitor skin impedance and temperature and deliver electrical stimulation in response to the wound environment. Across preclinical wound models, the treatment group healed ~25% more rapidly and with ~50% enhancement in dermal remodeling compared with control. Further, we observed activation of proregenerative genes in monocyte and macrophage cell populations, which may enhance tissue regeneration, neovascularization and dermal recovery.
A wireless ‘smart’ bandage stimulates wound healing.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>36424488</pmid><doi>10.1038/s41587-022-01528-3</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-1973-2204</orcidid><orcidid>https://orcid.org/0000-0002-6315-6921</orcidid><orcidid>https://orcid.org/0000-0002-0972-1715</orcidid><orcidid>https://orcid.org/0000-0001-9179-937X</orcidid><orcidid>https://orcid.org/0000-0002-0876-414X</orcidid><orcidid>https://orcid.org/0000-0002-7023-7850</orcidid><orcidid>https://orcid.org/0000-0003-2574-0534</orcidid><orcidid>https://orcid.org/0000-0003-1096-6637</orcidid><orcidid>https://orcid.org/0000-0003-0784-7987</orcidid><orcidid>https://orcid.org/0000-0001-9290-678X</orcidid><orcidid>https://orcid.org/0000-0002-8319-2479</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1087-0156 |
| ispartof | Nature biotechnology, 2023-05, Vol.41 (5), p.652-662 |
| issn | 1087-0156 1546-1696 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2740513388 |
| source | MEDLINE; Springer Nature - Complete Springer Journals; Nature |
| subjects | 639/166/985 639/301/923/1027 692/308/2778 692/699/578 692/700/565 Adhesion Agriculture Animals Bandages Bioelectricity Bioinformatics Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Biotechnology Closed loops Electrical stimuli Electrodes Environment models Hydrogels Life Sciences Macrophages Medical dressings Mice Monitoring, Physiologic Monocytes Regeneration (physiology) Sensors Signal transduction Skin Stimulation Stimulators Tissue engineering Transcription activation Vascularization Wearable Electronic Devices Wearable technology Wound Healing |
| title | Wireless, closed-loop, smart bandage with integrated sensors and stimulators for advanced wound care and accelerated healing |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T22%3A00%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Wireless,%20closed-loop,%20smart%20bandage%20with%20integrated%20sensors%20and%20stimulators%20for%20advanced%20wound%20care%20and%20accelerated%20healing&rft.jtitle=Nature%20biotechnology&rft.au=Jiang,%20Yuanwen&rft.date=2023-05-01&rft.volume=41&rft.issue=5&rft.spage=652&rft.epage=662&rft.pages=652-662&rft.issn=1087-0156&rft.eissn=1546-1696&rft_id=info:doi/10.1038/s41587-022-01528-3&rft_dat=%3Cproquest_cross%3E2814207744%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2814207744&rft_id=info:pmid/36424488&rfr_iscdi=true |