Circadian clock genes as promising therapeutic targets for bone loss
The circadian clock regulates many key physiological processes such as the sleep–wake cycle, hormone release, cardiovascular health, glucose metabolism and body temperature. Recent evidence has suggested a critical role of the circadian system in controlling bone metabolism. Here we review the conne...
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| Veröffentlicht in: | Biomedicine & pharmacotherapy 2023-01, Vol.157, p.114019-114019, Article 114019 |
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| container_title | Biomedicine & pharmacotherapy |
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| creator | Qin, Yi Chen, Zhong-hua Wu, Jun-Jie Zhang, Zhen-Yu Yuan, Zheng-Dong Guo, Dan-Yang Chen, Meng-Nan Li, Xia Yuan, Feng-Lai |
| description | The circadian clock regulates many key physiological processes such as the sleep–wake cycle, hormone release, cardiovascular health, glucose metabolism and body temperature. Recent evidence has suggested a critical role of the circadian system in controlling bone metabolism. Here we review the connection between bone metabolism and the biological clock, and the roles of these mechanisms in bone loss. We also analyze the regulatory effects of clock-related genes on signaling pathways and transcription factors in osteoblasts and osteoclasts. Additionally, osteocytes and endothelial cells (ECs) regulated by the circadian clock are also discussed in our review. Furthermore, we also summarize the regulation of circadian clock genes by some novel modulators, which provides us with a new insight into a potential strategy to prevent and treat bone diseases such as osteoporosis by targeting circadian genes.
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| doi_str_mv | 10.1016/j.biopha.2022.114019 |
| format | Article |
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[Display omitted]</description><identifier>ISSN: 0753-3322</identifier><identifier>EISSN: 1950-6007</identifier><identifier>DOI: 10.1016/j.biopha.2022.114019</identifier><identifier>PMID: 36423544</identifier><language>eng</language><publisher>France: Elsevier Masson SAS</publisher><subject>Biological Clocks ; Bone ; Circadian clock gene ; Circadian Rhythm - genetics ; Circadian rhythm, biological clock ; Endothelial Cells ; Osteoclasts ; Osteoporosis ; Transcription Factors</subject><ispartof>Biomedicine & pharmacotherapy, 2023-01, Vol.157, p.114019-114019, Article 114019</ispartof><rights>2022</rights><rights>Copyright © 2022. Published by Elsevier Masson SAS.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-f3afd6e5bbbf34689d9d56a665074cf15dfd5d8a6cc47bb71f030111615416b23</citedby><cites>FETCH-LOGICAL-c408t-f3afd6e5bbbf34689d9d56a665074cf15dfd5d8a6cc47bb71f030111615416b23</cites><orcidid>0000-0003-2141-3122</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0753332222014081$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36423544$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Qin, Yi</creatorcontrib><creatorcontrib>Chen, Zhong-hua</creatorcontrib><creatorcontrib>Wu, Jun-Jie</creatorcontrib><creatorcontrib>Zhang, Zhen-Yu</creatorcontrib><creatorcontrib>Yuan, Zheng-Dong</creatorcontrib><creatorcontrib>Guo, Dan-Yang</creatorcontrib><creatorcontrib>Chen, Meng-Nan</creatorcontrib><creatorcontrib>Li, Xia</creatorcontrib><creatorcontrib>Yuan, Feng-Lai</creatorcontrib><title>Circadian clock genes as promising therapeutic targets for bone loss</title><title>Biomedicine & pharmacotherapy</title><addtitle>Biomed Pharmacother</addtitle><description>The circadian clock regulates many key physiological processes such as the sleep–wake cycle, hormone release, cardiovascular health, glucose metabolism and body temperature. Recent evidence has suggested a critical role of the circadian system in controlling bone metabolism. Here we review the connection between bone metabolism and the biological clock, and the roles of these mechanisms in bone loss. We also analyze the regulatory effects of clock-related genes on signaling pathways and transcription factors in osteoblasts and osteoclasts. Additionally, osteocytes and endothelial cells (ECs) regulated by the circadian clock are also discussed in our review. Furthermore, we also summarize the regulation of circadian clock genes by some novel modulators, which provides us with a new insight into a potential strategy to prevent and treat bone diseases such as osteoporosis by targeting circadian genes.
[Display omitted]</description><subject>Biological Clocks</subject><subject>Bone</subject><subject>Circadian clock gene</subject><subject>Circadian Rhythm - genetics</subject><subject>Circadian rhythm, biological clock</subject><subject>Endothelial Cells</subject><subject>Osteoclasts</subject><subject>Osteoporosis</subject><subject>Transcription Factors</subject><issn>0753-3322</issn><issn>1950-6007</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kLtOAzEQRS0EgvD4A4Rc0mwYPzdpkFB4Skg0UFt-jIPDZjfYGyT-nkULlFTTnJl75xByymDKgOmL1dSlbvNqpxw4nzImgc13yITNFVQaoN4lE6iVqITg_IAclrICAKXFbJ8cCC25UFJOyPUiZW9Dsi31Teff6BJbLNQWusndOpXULmn_itlucNsnT3ubl9gXGrtMXdcibbpSjsletE3Bk595RF5ub54X99Xj093D4uqx8hJmfRWFjUGjcs5FIfVsHuZBaau1glr6yFSIQYWZ1d7L2rmaRRDAGNNMSaYdF0fkfLw7dHvfYunN0NBj09gWu20xvJagGNdCDqgcUZ-Hghmj2eS0tvnTMDDf_szKjP7Mtz8z-hvWzn4Stm6N4W_pV9gAXI4ADn9-JMym-IStx5Ay-t6ELv2f8AUgYoJ2</recordid><startdate>202301</startdate><enddate>202301</enddate><creator>Qin, Yi</creator><creator>Chen, Zhong-hua</creator><creator>Wu, Jun-Jie</creator><creator>Zhang, Zhen-Yu</creator><creator>Yuan, Zheng-Dong</creator><creator>Guo, Dan-Yang</creator><creator>Chen, Meng-Nan</creator><creator>Li, Xia</creator><creator>Yuan, Feng-Lai</creator><general>Elsevier Masson SAS</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2141-3122</orcidid></search><sort><creationdate>202301</creationdate><title>Circadian clock genes as promising therapeutic targets for bone loss</title><author>Qin, Yi ; Chen, Zhong-hua ; Wu, Jun-Jie ; Zhang, Zhen-Yu ; Yuan, Zheng-Dong ; Guo, Dan-Yang ; Chen, Meng-Nan ; Li, Xia ; Yuan, Feng-Lai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-f3afd6e5bbbf34689d9d56a665074cf15dfd5d8a6cc47bb71f030111615416b23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Biological Clocks</topic><topic>Bone</topic><topic>Circadian clock gene</topic><topic>Circadian Rhythm - genetics</topic><topic>Circadian rhythm, biological clock</topic><topic>Endothelial Cells</topic><topic>Osteoclasts</topic><topic>Osteoporosis</topic><topic>Transcription Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Qin, Yi</creatorcontrib><creatorcontrib>Chen, Zhong-hua</creatorcontrib><creatorcontrib>Wu, Jun-Jie</creatorcontrib><creatorcontrib>Zhang, Zhen-Yu</creatorcontrib><creatorcontrib>Yuan, Zheng-Dong</creatorcontrib><creatorcontrib>Guo, Dan-Yang</creatorcontrib><creatorcontrib>Chen, Meng-Nan</creatorcontrib><creatorcontrib>Li, Xia</creatorcontrib><creatorcontrib>Yuan, Feng-Lai</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biomedicine & pharmacotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Qin, Yi</au><au>Chen, Zhong-hua</au><au>Wu, Jun-Jie</au><au>Zhang, Zhen-Yu</au><au>Yuan, Zheng-Dong</au><au>Guo, Dan-Yang</au><au>Chen, Meng-Nan</au><au>Li, Xia</au><au>Yuan, Feng-Lai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circadian clock genes as promising therapeutic targets for bone loss</atitle><jtitle>Biomedicine & pharmacotherapy</jtitle><addtitle>Biomed Pharmacother</addtitle><date>2023-01</date><risdate>2023</risdate><volume>157</volume><spage>114019</spage><epage>114019</epage><pages>114019-114019</pages><artnum>114019</artnum><issn>0753-3322</issn><eissn>1950-6007</eissn><abstract>The circadian clock regulates many key physiological processes such as the sleep–wake cycle, hormone release, cardiovascular health, glucose metabolism and body temperature. 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| identifier | ISSN: 0753-3322 |
| ispartof | Biomedicine & pharmacotherapy, 2023-01, Vol.157, p.114019-114019, Article 114019 |
| issn | 0753-3322 1950-6007 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; EZB Electronic Journals Library |
| subjects | Biological Clocks Bone Circadian clock gene Circadian Rhythm - genetics Circadian rhythm, biological clock Endothelial Cells Osteoclasts Osteoporosis Transcription Factors |
| title | Circadian clock genes as promising therapeutic targets for bone loss |
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