Burden of migraine in Brazil: A cross‐sectional real‐world study
Objective To assess the burden and consequences of migraine in Brazil in terms of health‐related quality of life (HRQoL), work productivity and daily activities, and healthcare resource utilization (HRU). Background Despite existing data on how migraine affects populations worldwide, there are limit...
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| Veröffentlicht in: | Headache 2022-11, Vol.62 (10), p.1302-1311 |
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| creator | Souza, Marcio Nattan Portes Cohen, Joshua M. Piha, Tony Ribalov, Rinat Lengil, Tamar Laan, Andressa Calderaro, Marcelo Lee, Lulu K. |
| description | Objective
To assess the burden and consequences of migraine in Brazil in terms of health‐related quality of life (HRQoL), work productivity and daily activities, and healthcare resource utilization (HRU).
Background
Despite existing data on how migraine affects populations worldwide, there are limited data on the burden of migraine in Latin America.
Methods
This cross‐sectional study used patient‐reported data from the 2018 Brazil National Health and Wellness Survey. HRQoL scores (EuroQol 5‐dimension 5‐level [EQ‐5D‐5L]; 36‐item Short Form Health Survey, version 2 [SF‐36v2]; and Short Form 6‐dimension [SF‐6D]), impairments to work productivity and daily activities (Work Productivity and Activity Impairment questionnaire), and all‐cause HRU were compared between migraine respondents and matched non‐migraine controls.
Results
Of the 12,000 total respondents in the survey database, 1643 self‐reported a physician diagnosis of migraine and were propensity score matched 1:1 with controls without migraine. HRQoL was lower in patients with migraine versus non‐migraine controls, with significantly lower SF‐36v2 physical (mean [± SD] 50.3 [7.5] vs. 52.0 [7.6]) and mental component (mean [± SD] 42.9 [10.2] vs. 46.0 [9.9]) summary scores and SF‐6D (mean [± SD] 0.7 [0.1] vs. 0.7 [0.1]) and EQ‐5D‐5L (mean [± SD] 0.7 [0.2] vs. 0.8 [0.2]) utility scores (all p |
| doi_str_mv | 10.1111/head.14413 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2740512259</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2753511683</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2873-ce7fa432e57f5720c0de8c6c92a2792bcb5f7f31805b9a921396e23c0246f9173</originalsourceid><addsrcrecordid>eNp90MtKAzEUBuAgiq3VjQ8gATciTM09M-560woFN7oeMplEp6QzNelQ6spH8Bl9Eqed6sKF2RwIHz_n_ACcY9THzbt5NSrvY8YwPQBdzImImMDoEHQRwjKKJYs74CSEOUKIiUQcgw4VjAhJ4y4YD2ufmxJWFi6KF6-K0sCihEOv3gt3CwdQ-yqEr4_PYPSqqErloDfKNR_ryrschlWdb07BkVUumLP97IHnu8nTaBrNHu8fRoNZpEksaaSNtIpRYri0XBKkUW5iLXRCFJEJyXTGrbQUx4hniUoIpokwhGpEmLAJlrQHrtrcpa_eahNW6aII2jinSlPVISWSIY4J4UlDL__QeVX7Zv2t4pRjLGLaqOtW7a70xqZLXyyU36QYpdtu02236a7bBl_sI-tsYfJf-lNmA3AL1oUzm3-i0ulkMG5DvwHktINh</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2753511683</pqid></control><display><type>article</type><title>Burden of migraine in Brazil: A cross‐sectional real‐world study</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Souza, Marcio Nattan Portes ; Cohen, Joshua M. ; Piha, Tony ; Ribalov, Rinat ; Lengil, Tamar ; Laan, Andressa ; Calderaro, Marcelo ; Lee, Lulu K.</creator><creatorcontrib>Souza, Marcio Nattan Portes ; Cohen, Joshua M. ; Piha, Tony ; Ribalov, Rinat ; Lengil, Tamar ; Laan, Andressa ; Calderaro, Marcelo ; Lee, Lulu K.</creatorcontrib><description>Objective
To assess the burden and consequences of migraine in Brazil in terms of health‐related quality of life (HRQoL), work productivity and daily activities, and healthcare resource utilization (HRU).
Background
Despite existing data on how migraine affects populations worldwide, there are limited data on the burden of migraine in Latin America.
Methods
This cross‐sectional study used patient‐reported data from the 2018 Brazil National Health and Wellness Survey. HRQoL scores (EuroQol 5‐dimension 5‐level [EQ‐5D‐5L]; 36‐item Short Form Health Survey, version 2 [SF‐36v2]; and Short Form 6‐dimension [SF‐6D]), impairments to work productivity and daily activities (Work Productivity and Activity Impairment questionnaire), and all‐cause HRU were compared between migraine respondents and matched non‐migraine controls.
Results
Of the 12,000 total respondents in the survey database, 1643 self‐reported a physician diagnosis of migraine and were propensity score matched 1:1 with controls without migraine. HRQoL was lower in patients with migraine versus non‐migraine controls, with significantly lower SF‐36v2 physical (mean [± SD] 50.3 [7.5] vs. 52.0 [7.6]) and mental component (mean [± SD] 42.9 [10.2] vs. 46.0 [9.9]) summary scores and SF‐6D (mean [± SD] 0.7 [0.1] vs. 0.7 [0.1]) and EQ‐5D‐5L (mean [± SD] 0.7 [0.2] vs. 0.8 [0.2]) utility scores (all p < 0.001). Patients with migraine reported higher levels of work productivity loss (mean [± SD], 40.6% [31.4%] vs. 28.6% [30.9%], including absenteeism 12.8% [19.1%] vs. 8.4% [17.1%] and presenteeism 35.0% [28.7%] vs. 24.8% [28.0%]; all p < 0.001); activity impairment (mean [± SD] 36.0% [28.8%] vs. 25.5% [28.1%]; p < 0.001); and significantly higher HRU in the past 6 months (healthcare provider and emergency department visits [mean [± SD] 7.2 [9.5] vs. 4.5 [6.3] and 1.7 [3.8] vs. 0.9 [2.2]; both p < 0.001] and hospitalizations [mean [± SD] 0.4 [2.7] vs. 0.2 [1.1]; p = 0.002]) than controls.
Conclusion
Migraine is associated with poorer HRQoL, higher all‐cause HRU, and greater activity impairment and work productivity loss versus non‐migraine controls in Brazil.</description><identifier>ISSN: 0017-8748</identifier><identifier>EISSN: 1526-4610</identifier><identifier>DOI: 10.1111/head.14413</identifier><identifier>PMID: 36426738</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Absenteeism ; Brazil - epidemiology ; burden ; Cost of Illness ; Cross-Sectional Studies ; Emergency medical care ; Emergency medical services ; Headache ; Health care ; Health Surveys ; healthcare resource use ; health‐related quality of life ; Humans ; Impairment ; Migraine ; Migraine Disorders - epidemiology ; Patients ; Productivity ; Quality of Life ; Resource utilization ; Surveys ; work impairment</subject><ispartof>Headache, 2022-11, Vol.62 (10), p.1302-1311</ispartof><rights>2022 American Headache Society.</rights><rights>2022 American Headache Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2873-ce7fa432e57f5720c0de8c6c92a2792bcb5f7f31805b9a921396e23c0246f9173</citedby><cites>FETCH-LOGICAL-c2873-ce7fa432e57f5720c0de8c6c92a2792bcb5f7f31805b9a921396e23c0246f9173</cites><orcidid>0000-0003-4841-4491</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fhead.14413$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fhead.14413$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36426738$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Souza, Marcio Nattan Portes</creatorcontrib><creatorcontrib>Cohen, Joshua M.</creatorcontrib><creatorcontrib>Piha, Tony</creatorcontrib><creatorcontrib>Ribalov, Rinat</creatorcontrib><creatorcontrib>Lengil, Tamar</creatorcontrib><creatorcontrib>Laan, Andressa</creatorcontrib><creatorcontrib>Calderaro, Marcelo</creatorcontrib><creatorcontrib>Lee, Lulu K.</creatorcontrib><title>Burden of migraine in Brazil: A cross‐sectional real‐world study</title><title>Headache</title><addtitle>Headache</addtitle><description>Objective
To assess the burden and consequences of migraine in Brazil in terms of health‐related quality of life (HRQoL), work productivity and daily activities, and healthcare resource utilization (HRU).
Background
Despite existing data on how migraine affects populations worldwide, there are limited data on the burden of migraine in Latin America.
Methods
This cross‐sectional study used patient‐reported data from the 2018 Brazil National Health and Wellness Survey. HRQoL scores (EuroQol 5‐dimension 5‐level [EQ‐5D‐5L]; 36‐item Short Form Health Survey, version 2 [SF‐36v2]; and Short Form 6‐dimension [SF‐6D]), impairments to work productivity and daily activities (Work Productivity and Activity Impairment questionnaire), and all‐cause HRU were compared between migraine respondents and matched non‐migraine controls.
Results
Of the 12,000 total respondents in the survey database, 1643 self‐reported a physician diagnosis of migraine and were propensity score matched 1:1 with controls without migraine. HRQoL was lower in patients with migraine versus non‐migraine controls, with significantly lower SF‐36v2 physical (mean [± SD] 50.3 [7.5] vs. 52.0 [7.6]) and mental component (mean [± SD] 42.9 [10.2] vs. 46.0 [9.9]) summary scores and SF‐6D (mean [± SD] 0.7 [0.1] vs. 0.7 [0.1]) and EQ‐5D‐5L (mean [± SD] 0.7 [0.2] vs. 0.8 [0.2]) utility scores (all p < 0.001). Patients with migraine reported higher levels of work productivity loss (mean [± SD], 40.6% [31.4%] vs. 28.6% [30.9%], including absenteeism 12.8% [19.1%] vs. 8.4% [17.1%] and presenteeism 35.0% [28.7%] vs. 24.8% [28.0%]; all p < 0.001); activity impairment (mean [± SD] 36.0% [28.8%] vs. 25.5% [28.1%]; p < 0.001); and significantly higher HRU in the past 6 months (healthcare provider and emergency department visits [mean [± SD] 7.2 [9.5] vs. 4.5 [6.3] and 1.7 [3.8] vs. 0.9 [2.2]; both p < 0.001] and hospitalizations [mean [± SD] 0.4 [2.7] vs. 0.2 [1.1]; p = 0.002]) than controls.
Conclusion
Migraine is associated with poorer HRQoL, higher all‐cause HRU, and greater activity impairment and work productivity loss versus non‐migraine controls in Brazil.</description><subject>Absenteeism</subject><subject>Brazil - epidemiology</subject><subject>burden</subject><subject>Cost of Illness</subject><subject>Cross-Sectional Studies</subject><subject>Emergency medical care</subject><subject>Emergency medical services</subject><subject>Headache</subject><subject>Health care</subject><subject>Health Surveys</subject><subject>healthcare resource use</subject><subject>health‐related quality of life</subject><subject>Humans</subject><subject>Impairment</subject><subject>Migraine</subject><subject>Migraine Disorders - epidemiology</subject><subject>Patients</subject><subject>Productivity</subject><subject>Quality of Life</subject><subject>Resource utilization</subject><subject>Surveys</subject><subject>work impairment</subject><issn>0017-8748</issn><issn>1526-4610</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90MtKAzEUBuAgiq3VjQ8gATciTM09M-560woFN7oeMplEp6QzNelQ6spH8Bl9Eqed6sKF2RwIHz_n_ACcY9THzbt5NSrvY8YwPQBdzImImMDoEHQRwjKKJYs74CSEOUKIiUQcgw4VjAhJ4y4YD2ufmxJWFi6KF6-K0sCihEOv3gt3CwdQ-yqEr4_PYPSqqErloDfKNR_ryrschlWdb07BkVUumLP97IHnu8nTaBrNHu8fRoNZpEksaaSNtIpRYri0XBKkUW5iLXRCFJEJyXTGrbQUx4hniUoIpokwhGpEmLAJlrQHrtrcpa_eahNW6aII2jinSlPVISWSIY4J4UlDL__QeVX7Zv2t4pRjLGLaqOtW7a70xqZLXyyU36QYpdtu02236a7bBl_sI-tsYfJf-lNmA3AL1oUzm3-i0ulkMG5DvwHktINh</recordid><startdate>202211</startdate><enddate>202211</enddate><creator>Souza, Marcio Nattan Portes</creator><creator>Cohen, Joshua M.</creator><creator>Piha, Tony</creator><creator>Ribalov, Rinat</creator><creator>Lengil, Tamar</creator><creator>Laan, Andressa</creator><creator>Calderaro, Marcelo</creator><creator>Lee, Lulu K.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4841-4491</orcidid></search><sort><creationdate>202211</creationdate><title>Burden of migraine in Brazil: A cross‐sectional real‐world study</title><author>Souza, Marcio Nattan Portes ; Cohen, Joshua M. ; Piha, Tony ; Ribalov, Rinat ; Lengil, Tamar ; Laan, Andressa ; Calderaro, Marcelo ; Lee, Lulu K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2873-ce7fa432e57f5720c0de8c6c92a2792bcb5f7f31805b9a921396e23c0246f9173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Absenteeism</topic><topic>Brazil - epidemiology</topic><topic>burden</topic><topic>Cost of Illness</topic><topic>Cross-Sectional Studies</topic><topic>Emergency medical care</topic><topic>Emergency medical services</topic><topic>Headache</topic><topic>Health care</topic><topic>Health Surveys</topic><topic>healthcare resource use</topic><topic>health‐related quality of life</topic><topic>Humans</topic><topic>Impairment</topic><topic>Migraine</topic><topic>Migraine Disorders - epidemiology</topic><topic>Patients</topic><topic>Productivity</topic><topic>Quality of Life</topic><topic>Resource utilization</topic><topic>Surveys</topic><topic>work impairment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Souza, Marcio Nattan Portes</creatorcontrib><creatorcontrib>Cohen, Joshua M.</creatorcontrib><creatorcontrib>Piha, Tony</creatorcontrib><creatorcontrib>Ribalov, Rinat</creatorcontrib><creatorcontrib>Lengil, Tamar</creatorcontrib><creatorcontrib>Laan, Andressa</creatorcontrib><creatorcontrib>Calderaro, Marcelo</creatorcontrib><creatorcontrib>Lee, Lulu K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Headache</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Souza, Marcio Nattan Portes</au><au>Cohen, Joshua M.</au><au>Piha, Tony</au><au>Ribalov, Rinat</au><au>Lengil, Tamar</au><au>Laan, Andressa</au><au>Calderaro, Marcelo</au><au>Lee, Lulu K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Burden of migraine in Brazil: A cross‐sectional real‐world study</atitle><jtitle>Headache</jtitle><addtitle>Headache</addtitle><date>2022-11</date><risdate>2022</risdate><volume>62</volume><issue>10</issue><spage>1302</spage><epage>1311</epage><pages>1302-1311</pages><issn>0017-8748</issn><eissn>1526-4610</eissn><abstract>Objective
To assess the burden and consequences of migraine in Brazil in terms of health‐related quality of life (HRQoL), work productivity and daily activities, and healthcare resource utilization (HRU).
Background
Despite existing data on how migraine affects populations worldwide, there are limited data on the burden of migraine in Latin America.
Methods
This cross‐sectional study used patient‐reported data from the 2018 Brazil National Health and Wellness Survey. HRQoL scores (EuroQol 5‐dimension 5‐level [EQ‐5D‐5L]; 36‐item Short Form Health Survey, version 2 [SF‐36v2]; and Short Form 6‐dimension [SF‐6D]), impairments to work productivity and daily activities (Work Productivity and Activity Impairment questionnaire), and all‐cause HRU were compared between migraine respondents and matched non‐migraine controls.
Results
Of the 12,000 total respondents in the survey database, 1643 self‐reported a physician diagnosis of migraine and were propensity score matched 1:1 with controls without migraine. HRQoL was lower in patients with migraine versus non‐migraine controls, with significantly lower SF‐36v2 physical (mean [± SD] 50.3 [7.5] vs. 52.0 [7.6]) and mental component (mean [± SD] 42.9 [10.2] vs. 46.0 [9.9]) summary scores and SF‐6D (mean [± SD] 0.7 [0.1] vs. 0.7 [0.1]) and EQ‐5D‐5L (mean [± SD] 0.7 [0.2] vs. 0.8 [0.2]) utility scores (all p < 0.001). Patients with migraine reported higher levels of work productivity loss (mean [± SD], 40.6% [31.4%] vs. 28.6% [30.9%], including absenteeism 12.8% [19.1%] vs. 8.4% [17.1%] and presenteeism 35.0% [28.7%] vs. 24.8% [28.0%]; all p < 0.001); activity impairment (mean [± SD] 36.0% [28.8%] vs. 25.5% [28.1%]; p < 0.001); and significantly higher HRU in the past 6 months (healthcare provider and emergency department visits [mean [± SD] 7.2 [9.5] vs. 4.5 [6.3] and 1.7 [3.8] vs. 0.9 [2.2]; both p < 0.001] and hospitalizations [mean [± SD] 0.4 [2.7] vs. 0.2 [1.1]; p = 0.002]) than controls.
Conclusion
Migraine is associated with poorer HRQoL, higher all‐cause HRU, and greater activity impairment and work productivity loss versus non‐migraine controls in Brazil.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>36426738</pmid><doi>10.1111/head.14413</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-4841-4491</orcidid></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Absenteeism Brazil - epidemiology burden Cost of Illness Cross-Sectional Studies Emergency medical care Emergency medical services Headache Health care Health Surveys healthcare resource use health‐related quality of life Humans Impairment Migraine Migraine Disorders - epidemiology Patients Productivity Quality of Life Resource utilization Surveys work impairment |
| title | Burden of migraine in Brazil: A cross‐sectional real‐world study |
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