Clinical effects and emerging issues of atezolizumab plus bevacizumab in patients with advanced hepatocellular carcinoma from Japanese real‐world practice

Background Although the efficacy of atezolizumab has been demonstrated in randomized controlled trials, its long‐term efficacy and association with adverse events in real‐world practice are unknown. This study was designed to shed light on these issues. Methods In this multicenter retrospective stud...

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Veröffentlicht in:	Cancer 2023-02, Vol.129 (4), p.590-599
Hauptverfasser:	Nakagawa, Miyuki, Inoue, Masanori, Ogasawara, Sadahisa, Maruta, Susumu, Okubo, Tomomi, Itokawa, Norio, Iino, Yotaro, Obu, Masamichi, Haga, Yuki, Seki, Atsuyoshi, Kikuchi, Yasuharu, Kogure, Tadayoshi, Yumita, Sae, Ishino, Takamasa, Ogawa, Keita, Fujiwara, Kisako, Iwanaga, Terunao, Fujita, Naoto, Sakuma, Takafumi, Kojima, Ryuta, Kanzaki, Hiroaki, Koroki, Keisuke, Taida, Takashi, Kobayashi, Kazufumi, Kiyono, Soichiro, Nakamura, Masato, Kanogawa, Naoya, Kondo, Takayuki, Nakagawa, Ryo, Nakamoto, Shingo, Muroyama, Ryosuke, Chiba, Tetsuhiro, Itobayashi, Ei, Atsukawa, Masanori, Koma, Yoshihiro, Azemoto, Ryosaku, Ito, Kenji, Mizumoto, Hideaki, Shinozaki, Masami, Kato, Jun, Kato, Naoya
Format:	Artikel
Sprache:	eng
Schlagworte:	Adverse events Antineoplastic Combined Chemotherapy Protocols - adverse effects anti‐VEGF agent atezolizumab Bevacizumab Carcinoma, Hepatocellular - drug therapy Clinical trials Diabetes Diabetes mellitus East Asian People Effectiveness Fatty liver Growth factors Health services Hepatocellular carcinoma Humans Hypertension Hypertension - chemically induced Hypertension - drug therapy Hypertension - epidemiology Immunotherapy Liver Liver cancer Liver diseases Liver Neoplasms - drug therapy Metabolic disorders Metabolic syndrome Monoclonal antibodies Oncology Patients Proteinuria Retrospective Studies Targeted cancer therapy Vascular endothelial growth factor Vascular Endothelial Growth Factor A
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